Antimicrobial peptides´ immune modulation role in intracellular bacterial infection
Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to eliminate the infection because they have poor cellular uptake and do not reach the concentrations needed to k...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1119574/full |
| _version_ | 1797859053247922176 |
|---|---|
| author | Diana Ivonne Duarte-Mata Mario César Salinas-Carmona |
| author_facet | Diana Ivonne Duarte-Mata Mario César Salinas-Carmona |
| author_sort | Diana Ivonne Duarte-Mata |
| collection | DOAJ |
| description | Intracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to eliminate the infection because they have poor cellular uptake and do not reach the concentrations needed to kill bacteria. In this context, antimicrobial peptides (AMPs) are a promising therapeutic approach. AMPs are short cationic peptides. They are essential components of the innate immune response and important candidates for therapy due to their bactericidal properties and ability to modulate host immune responses. AMPs control infections through their diverse immunomodulatory effects stimulating and/or boosting immune responses. This review focuses on AMPs described to treat intracellular bacterial infections and the known immune mechanisms they influence. |
| first_indexed | 2024-04-09T21:23:16Z |
| format | Article |
| id | doaj.art-f0aacf227bc14cf99ad278bc1539d046 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T21:23:16Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f0aacf227bc14cf99ad278bc1539d0462023-03-28T04:30:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11195741119574Antimicrobial peptides´ immune modulation role in intracellular bacterial infectionDiana Ivonne Duarte-MataMario César Salinas-CarmonaIntracellular bacteria cause a wide range of diseases, and their intracellular lifestyle makes infections difficult to resolve. Furthermore, standard therapy antibiotics are often unable to eliminate the infection because they have poor cellular uptake and do not reach the concentrations needed to kill bacteria. In this context, antimicrobial peptides (AMPs) are a promising therapeutic approach. AMPs are short cationic peptides. They are essential components of the innate immune response and important candidates for therapy due to their bactericidal properties and ability to modulate host immune responses. AMPs control infections through their diverse immunomodulatory effects stimulating and/or boosting immune responses. This review focuses on AMPs described to treat intracellular bacterial infections and the known immune mechanisms they influence.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1119574/fullhost defense peptidesimmunomodulationantimicrobial peptidesintracellular bacterial infectioncell-penetrating peptides |
| spellingShingle | Diana Ivonne Duarte-Mata Mario César Salinas-Carmona Antimicrobial peptides´ immune modulation role in intracellular bacterial infection Frontiers in Immunology host defense peptides immunomodulation antimicrobial peptides intracellular bacterial infection cell-penetrating peptides |
| title | Antimicrobial peptides´ immune modulation role in intracellular bacterial infection |
| title_full | Antimicrobial peptides´ immune modulation role in intracellular bacterial infection |
| title_fullStr | Antimicrobial peptides´ immune modulation role in intracellular bacterial infection |
| title_full_unstemmed | Antimicrobial peptides´ immune modulation role in intracellular bacterial infection |
| title_short | Antimicrobial peptides´ immune modulation role in intracellular bacterial infection |
| title_sort | antimicrobial peptides´ immune modulation role in intracellular bacterial infection |
| topic | host defense peptides immunomodulation antimicrobial peptides intracellular bacterial infection cell-penetrating peptides |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1119574/full |
| work_keys_str_mv | AT dianaivonneduartemata antimicrobialpeptidesimmunemodulationroleinintracellularbacterialinfection AT mariocesarsalinascarmona antimicrobialpeptidesimmunemodulationroleinintracellularbacterialinfection |