Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial
Abstract Background A high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of the colon capsule within battery life time (excretion rate). Methods One...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-06-01
|
| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-018-0824-9 |
| _version_ | 1818201665863417856 |
|---|---|
| author | Maria Magdalena Buijs Morten Kobaek-Larsen Lasse Kaalby Gunnar Baatrup |
| author_facet | Maria Magdalena Buijs Morten Kobaek-Larsen Lasse Kaalby Gunnar Baatrup |
| author_sort | Maria Magdalena Buijs |
| collection | DOAJ |
| description | Abstract Background A high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of the colon capsule within battery life time (excretion rate). Methods One hundred eighty six screening participants with a positive immunochemical fecal occult blood test were included in this single-centre randomized controlled trial with blinding of the investigators to the randomization. Participants received instant coffee, chewing gum or nothing in addition to the standard bowel preparation. Results The intention was to include 57 participants in the coffee group, 61 in the chewing gum group and 60 in the control group, on 8 participants data were missing. A total of 165 participants were included in a per protocol analysis. Exclusion was due to not receiving the allocated intervention (8 coffee, 4 chewing gum) and technical failure of the capsule (1 coffee). The excretion rate was 58% in the coffee group (n = 48), 63% in the chewing gum group (n = 57) and 55% in the control group (n = 60, p > 0.2). Transit times were similar in all groups. The excretion rate was low in participants who had transit times over 10 h (14%). A strong correlation was found between adequate cleansing and excretion of the capsule. There were no serious adverse events related to the interventions or CCE investigations. Conclusions Chewing gum and coffee did not improve excretion rate in this study. An effect of chewing gum could not be proven, possibly due to sample size. Since chewing gum might improve excretion rates, is cheap and has no known side effects, it needs to be considered in future bowel preparation trials for CCE. Trial registration NCT02303756, registered on December 1st 2014. |
| first_indexed | 2024-12-12T02:57:10Z |
| format | Article |
| id | doaj.art-f0aaf23efe7749babf8b3a26d3047b48 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-12T02:57:10Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-f0aaf23efe7749babf8b3a26d3047b482022-12-22T00:40:42ZengBMCBMC Gastroenterology1471-230X2018-06-011811510.1186/s12876-018-0824-9Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trialMaria Magdalena Buijs0Morten Kobaek-Larsen1Lasse Kaalby2Gunnar Baatrup3Department of Clinical Research, University of Southern DenmarkDepartment of Clinical Research, University of Southern DenmarkDepartment of Clinical Research, University of Southern DenmarkDepartment of Clinical Research, University of Southern DenmarkAbstract Background A high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of the colon capsule within battery life time (excretion rate). Methods One hundred eighty six screening participants with a positive immunochemical fecal occult blood test were included in this single-centre randomized controlled trial with blinding of the investigators to the randomization. Participants received instant coffee, chewing gum or nothing in addition to the standard bowel preparation. Results The intention was to include 57 participants in the coffee group, 61 in the chewing gum group and 60 in the control group, on 8 participants data were missing. A total of 165 participants were included in a per protocol analysis. Exclusion was due to not receiving the allocated intervention (8 coffee, 4 chewing gum) and technical failure of the capsule (1 coffee). The excretion rate was 58% in the coffee group (n = 48), 63% in the chewing gum group (n = 57) and 55% in the control group (n = 60, p > 0.2). Transit times were similar in all groups. The excretion rate was low in participants who had transit times over 10 h (14%). A strong correlation was found between adequate cleansing and excretion of the capsule. There were no serious adverse events related to the interventions or CCE investigations. Conclusions Chewing gum and coffee did not improve excretion rate in this study. An effect of chewing gum could not be proven, possibly due to sample size. Since chewing gum might improve excretion rates, is cheap and has no known side effects, it needs to be considered in future bowel preparation trials for CCE. Trial registration NCT02303756, registered on December 1st 2014.http://link.springer.com/article/10.1186/s12876-018-0824-9Colon capsule endoscopyTransit timeExcretion rateBowel preparationCoffeeChewing gum |
| spellingShingle | Maria Magdalena Buijs Morten Kobaek-Larsen Lasse Kaalby Gunnar Baatrup Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial BMC Gastroenterology Colon capsule endoscopy Transit time Excretion rate Bowel preparation Coffee Chewing gum |
| title | Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial |
| title_full | Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial |
| title_fullStr | Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial |
| title_full_unstemmed | Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial |
| title_short | Can coffee or chewing gum decrease transit times in Colon capsule endoscopy? A randomized controlled trial |
| title_sort | can coffee or chewing gum decrease transit times in colon capsule endoscopy a randomized controlled trial |
| topic | Colon capsule endoscopy Transit time Excretion rate Bowel preparation Coffee Chewing gum |
| url | http://link.springer.com/article/10.1186/s12876-018-0824-9 |
| work_keys_str_mv | AT mariamagdalenabuijs cancoffeeorchewinggumdecreasetransittimesincoloncapsuleendoscopyarandomizedcontrolledtrial AT mortenkobaeklarsen cancoffeeorchewinggumdecreasetransittimesincoloncapsuleendoscopyarandomizedcontrolledtrial AT lassekaalby cancoffeeorchewinggumdecreasetransittimesincoloncapsuleendoscopyarandomizedcontrolledtrial AT gunnarbaatrup cancoffeeorchewinggumdecreasetransittimesincoloncapsuleendoscopyarandomizedcontrolledtrial |