Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1

Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1

DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG–binding domain protein 2 (MBD2), a protein reader of methylation, is involved in the development of acute kidney injury (AKI) caused by vancomycin. However, the role and mechanism of action of MBD2 in renal remain...

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Bibliographic Details
Main Authors: Kai Ai, Xiaozhou Li, Pan Zhang, Jian Pan, Huiling Li, Zhibiao He, Hongliang Zhang, Lei Yi, Ye Kang, Yinhuai Wang, Junxiang Chen, Yijian Li, Xudong Xiang, Xiangping Chai, Dongshan Zhang
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Bioinformatics
MBD2
EGR1
renal fibrosis
UUO
I/R
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122000439

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