Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences
Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/21/5190 |
| _version_ | 1797512256289767424 |
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| author | Tor Henrik Anderson Tvedt Anh Khoi Vo Øystein Bruserud Håkon Reikvam |
| author_facet | Tor Henrik Anderson Tvedt Anh Khoi Vo Øystein Bruserud Håkon Reikvam |
| author_sort | Tor Henrik Anderson Tvedt |
| collection | DOAJ |
| description | Cytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-HSCT). Severe CRS can be life-threatening in some cases and requires prompt management of those toxicities and is still a great challenge for physicians. The pathophysiology of CRS is still not fully understood, which also applies to the identifications of predictive biomarkers that can forecast these features in advance. However, a broad range of cytokines are involved in the dynamics of CRS. Treatment approaches include both broad spectrum of immunosuppressant, such as corticosteroids, as well as more specific inhibition of cytokine release. In the present manuscript we will try to review an update regarding pathophysiology, etiology, diagnostics, and therapeutic options for this serious complication. |
| first_indexed | 2024-03-10T05:59:15Z |
| format | Article |
| id | doaj.art-f0af6da2777f473186d1684ee863dffe |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T05:59:15Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f0af6da2777f473186d1684ee863dffe2023-11-22T21:08:41ZengMDPI AGJournal of Clinical Medicine2077-03832021-11-011021519010.3390/jcm10215190Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical ConsequencesTor Henrik Anderson Tvedt0Anh Khoi Vo1Øystein Bruserud2Håkon Reikvam3Department of Hematology, Oslo University Hospital, 0372 Oslo, NorwayDepartment of Clinical Science, University of Bergen, 5020 Bergen, NorwayDepartment of Clinical Science, University of Bergen, 5020 Bergen, NorwayDepartment of Clinical Science, University of Bergen, 5020 Bergen, NorwayCytokine release syndrome (CRS) is an acute systemic inflammatory syndrome characterized by fever and multiple organ dysfunction associated with (i) chimeric antigen receptor (CAR)-T cell therapy, (ii) therapeutic antibodies, and (iii) haploidentical allogeneic stem cell transplantation (haplo-allo-HSCT). Severe CRS can be life-threatening in some cases and requires prompt management of those toxicities and is still a great challenge for physicians. The pathophysiology of CRS is still not fully understood, which also applies to the identifications of predictive biomarkers that can forecast these features in advance. However, a broad range of cytokines are involved in the dynamics of CRS. Treatment approaches include both broad spectrum of immunosuppressant, such as corticosteroids, as well as more specific inhibition of cytokine release. In the present manuscript we will try to review an update regarding pathophysiology, etiology, diagnostics, and therapeutic options for this serious complication.https://www.mdpi.com/2077-0383/10/21/5190cytokineschimeric antigen receptortherapeutic antibodieshaploidentical allogeneic stem cell transplantation |
| spellingShingle | Tor Henrik Anderson Tvedt Anh Khoi Vo Øystein Bruserud Håkon Reikvam Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences Journal of Clinical Medicine cytokines chimeric antigen receptor therapeutic antibodies haploidentical allogeneic stem cell transplantation |
| title | Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences |
| title_full | Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences |
| title_fullStr | Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences |
| title_full_unstemmed | Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences |
| title_short | Cytokine Release Syndrome in the Immunotherapy of Hematological Malignancies: The Biology behind and Possible Clinical Consequences |
| title_sort | cytokine release syndrome in the immunotherapy of hematological malignancies the biology behind and possible clinical consequences |
| topic | cytokines chimeric antigen receptor therapeutic antibodies haploidentical allogeneic stem cell transplantation |
| url | https://www.mdpi.com/2077-0383/10/21/5190 |
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