Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis

Duhuo Jisheng Decoction suppresses apoptosis and mitochondrial dysfunction in human nucleus pulposus cells by miR-494/SIRT3/mitophagy signal axis

Abstract Background Increasing evidence suggests that mitophagy is responsible for the pathogenesis of intervertebral disk (IVD) degeneration. Previous studies have shown that Duhuo Jisheng Decoction (DHJSD), a classic Fangji of traditional Chinese medicine, can delay IVD degeneration; however, its...

Full description

Bibliographic Details
Main Authors: Wei Liu, Xiaolong Zhao, Xuejian Wu
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Intervertebral disk degeneration
miR-494
SIRT3
Mitophagy
Duhuo Jisheng Decoction
Online Access:https://doi.org/10.1186/s13018-023-03669-w

Similar Items

Similar Items