Epigenetics in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease with unknown pathogenesis and complex pathological manifestations. At present, a large number of studies on targeted drugs for the typical pathological phenomenon of AD (Aβ) have ended in failure. Although there are some drugs on the market tha...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.911635/full |
| _version_ | 1811343726881013760 |
|---|---|
| author | Xiaodie Gao Xiaodie Gao Qiang Chen Hua Yao Jie Tan Zheng Liu Yan Zhou Zhenyou Zou Zhenyou Zou |
| author_facet | Xiaodie Gao Xiaodie Gao Qiang Chen Hua Yao Jie Tan Zheng Liu Yan Zhou Zhenyou Zou Zhenyou Zou |
| author_sort | Xiaodie Gao |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a neurodegenerative disease with unknown pathogenesis and complex pathological manifestations. At present, a large number of studies on targeted drugs for the typical pathological phenomenon of AD (Aβ) have ended in failure. Although there are some drugs on the market that indirectly act on AD, their efficacy is very low and the side effects are substantial, so there is an urgent need to develop a new strategy for the treatment of AD. An increasing number of studies have confirmed epigenetic changes in AD. Although it is not clear whether these epigenetic changes are the cause or result of AD, they provide a new avenue of treatment for medical researchers worldwide. This article summarizes various epigenetic changes in AD, including DNA methylation, histone modification and miRNA, and concludes that epigenetics has great potential as a new target for the treatment of AD. |
| first_indexed | 2024-04-13T19:33:57Z |
| format | Article |
| id | doaj.art-f0b1829a58ed46939d42e7e3badb1517 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T19:33:57Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f0b1829a58ed46939d42e7e3badb15172022-12-22T02:33:06ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-06-011410.3389/fnagi.2022.911635911635Epigenetics in Alzheimer’s DiseaseXiaodie Gao0Xiaodie Gao1Qiang Chen2Hua Yao3Jie Tan4Zheng Liu5Yan Zhou6Zhenyou Zou7Zhenyou Zou8Guangxi Key Lab of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, ChinaDepartment of Scientific Research, Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, ChinaDepartment of Scientific Research, Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, ChinaGuangxi Key Lab of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, ChinaGuangxi Key Lab of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, ChinaGuangxi Key Lab of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, ChinaGuangxi Key Lab of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, ChinaGuangxi Key Lab of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, ChinaDepartment of Scientific Research, Brain Hospital of Guangxi Zhuang Autonomous Region, Liuzhou, ChinaAlzheimer’s disease (AD) is a neurodegenerative disease with unknown pathogenesis and complex pathological manifestations. At present, a large number of studies on targeted drugs for the typical pathological phenomenon of AD (Aβ) have ended in failure. Although there are some drugs on the market that indirectly act on AD, their efficacy is very low and the side effects are substantial, so there is an urgent need to develop a new strategy for the treatment of AD. An increasing number of studies have confirmed epigenetic changes in AD. Although it is not clear whether these epigenetic changes are the cause or result of AD, they provide a new avenue of treatment for medical researchers worldwide. This article summarizes various epigenetic changes in AD, including DNA methylation, histone modification and miRNA, and concludes that epigenetics has great potential as a new target for the treatment of AD.https://www.frontiersin.org/articles/10.3389/fnagi.2022.911635/fullAlzheimer’s diseaseepigeneticsmethylationacetylationubiquitination |
| spellingShingle | Xiaodie Gao Xiaodie Gao Qiang Chen Hua Yao Jie Tan Zheng Liu Yan Zhou Zhenyou Zou Zhenyou Zou Epigenetics in Alzheimer’s Disease Frontiers in Aging Neuroscience Alzheimer’s disease epigenetics methylation acetylation ubiquitination |
| title | Epigenetics in Alzheimer’s Disease |
| title_full | Epigenetics in Alzheimer’s Disease |
| title_fullStr | Epigenetics in Alzheimer’s Disease |
| title_full_unstemmed | Epigenetics in Alzheimer’s Disease |
| title_short | Epigenetics in Alzheimer’s Disease |
| title_sort | epigenetics in alzheimer s disease |
| topic | Alzheimer’s disease epigenetics methylation acetylation ubiquitination |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.911635/full |
| work_keys_str_mv | AT xiaodiegao epigeneticsinalzheimersdisease AT xiaodiegao epigeneticsinalzheimersdisease AT qiangchen epigeneticsinalzheimersdisease AT huayao epigeneticsinalzheimersdisease AT jietan epigeneticsinalzheimersdisease AT zhengliu epigeneticsinalzheimersdisease AT yanzhou epigeneticsinalzheimersdisease AT zhenyouzou epigeneticsinalzheimersdisease AT zhenyouzou epigeneticsinalzheimersdisease |