Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort
Objective: To evaluate the real-world effectiveness of integrative medicine treatment on quality of life using the Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER). Design: A prospective, longitudinal, observational evaluation of patient reported outcomes for quality of life....
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Complementary Therapies in Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0965229922001078 |
| _version_ | 1811178605683671040 |
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| author | Jeffery A. Dusek Qi Gao Ryung S. Kim Donald I. Abrams Benjamin Kligler Natalie L. Dyer Kathryn Hansen M. Diane McKee |
| author_facet | Jeffery A. Dusek Qi Gao Ryung S. Kim Donald I. Abrams Benjamin Kligler Natalie L. Dyer Kathryn Hansen M. Diane McKee |
| author_sort | Jeffery A. Dusek |
| collection | DOAJ |
| description | Objective: To evaluate the real-world effectiveness of integrative medicine treatment on quality of life using the Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER). Design: A prospective, longitudinal, observational evaluation of patient reported outcomes for quality of life. Setting: Participants were patients from 17 integrative medicine clinics who received personalized, integrative medicine treatments between August 2013 and October 2017. Main outcome measures: Participants completed the Patient Reported Outcomes Measurement Information System (PROMIS)− 29, Perceived Stress Scale-4 (PSS-4), and the Patient Activation Measure (PAM) at index (baseline) visit and at 2, 4, 6, and 12 month follow-up assessments. Electronic health record data included diagnostic and billing codes/descriptions. A linear mixed-effects model was used to test whether outcomes changed from index through 12 months Results: During enrollment, 4883 participants began the assessment, 3658 completed the index measures, and 2374 (65 %) completed at least 1 follow-up assessment, had electronic health record data and at least 1 integrative medicine visit. Most participants (mean age=51.4 years) were white (88.4 %), female (79.7 %), and college-educated (78.5 %). Significant improvements (p < 0.001) were observed at 12-months on all PROMIS-29 measures, PSS-4, and PAM. At 12 months, clinically meaningful improvements were found for 38 % and 28 % on PROMIS-29 Mental and Physical Health Summary scores respectively. Conclusions: PRIMIER is the largest study to assess the real-world effectiveness of integrative medicine. Results indicate a statistical and clinical improvement across all measures at 12 months. Future research could explore whether dosing, timing or combinations of integrative medicine interventions have differential impacts on quality of life. |
| first_indexed | 2024-04-11T06:21:22Z |
| format | Article |
| id | doaj.art-f0b3fc0e41904bfda32b67377a288056 |
| institution | Directory Open Access Journal |
| issn | 0965-2299 |
| language | English |
| last_indexed | 2024-04-11T06:21:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj.art-f0b3fc0e41904bfda32b67377a2880562022-12-22T04:40:34ZengElsevierComplementary Therapies in Medicine0965-22992022-12-0171102904Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohortJeffery A. Dusek0Qi Gao1Ryung S. Kim2Donald I. Abrams3Benjamin Kligler4Natalie L. Dyer5Kathryn Hansen6M. Diane McKee7Connor Whole Health, University Hospitals, Cleveland, OH, USA; Department of Family Medicine and Community Health, Case Western Reserve University School of Medicine, Cleveland, OH, USA; Correspondence to: University Hospitals Connor Whole Health Cleveland Medical Center, 11000 Euclid Ave, Cleveland, OH 44106, USA.Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York USADepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York USAOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA, USAOffice of Patient Centered Care & Cultural Transformation, Veteran’s Administration, Washington DC, USAConnor Whole Health, University Hospitals, Cleveland, OH, USAOsher Center for Integrative Medicine, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York USA; Department of Family Medicine, University of Massachusetts School of Medicine, Worcester, MA USAObjective: To evaluate the real-world effectiveness of integrative medicine treatment on quality of life using the Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER). Design: A prospective, longitudinal, observational evaluation of patient reported outcomes for quality of life. Setting: Participants were patients from 17 integrative medicine clinics who received personalized, integrative medicine treatments between August 2013 and October 2017. Main outcome measures: Participants completed the Patient Reported Outcomes Measurement Information System (PROMIS)− 29, Perceived Stress Scale-4 (PSS-4), and the Patient Activation Measure (PAM) at index (baseline) visit and at 2, 4, 6, and 12 month follow-up assessments. Electronic health record data included diagnostic and billing codes/descriptions. A linear mixed-effects model was used to test whether outcomes changed from index through 12 months Results: During enrollment, 4883 participants began the assessment, 3658 completed the index measures, and 2374 (65 %) completed at least 1 follow-up assessment, had electronic health record data and at least 1 integrative medicine visit. Most participants (mean age=51.4 years) were white (88.4 %), female (79.7 %), and college-educated (78.5 %). Significant improvements (p < 0.001) were observed at 12-months on all PROMIS-29 measures, PSS-4, and PAM. At 12 months, clinically meaningful improvements were found for 38 % and 28 % on PROMIS-29 Mental and Physical Health Summary scores respectively. Conclusions: PRIMIER is the largest study to assess the real-world effectiveness of integrative medicine. Results indicate a statistical and clinical improvement across all measures at 12 months. Future research could explore whether dosing, timing or combinations of integrative medicine interventions have differential impacts on quality of life.http://www.sciencedirect.com/science/article/pii/S0965229922001078Observational StudyPractice-Based ResearchStressPROMISIntegrative MedicineAcupuncture |
| spellingShingle | Jeffery A. Dusek Qi Gao Ryung S. Kim Donald I. Abrams Benjamin Kligler Natalie L. Dyer Kathryn Hansen M. Diane McKee Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort Complementary Therapies in Medicine Observational Study Practice-Based Research Stress PROMIS Integrative Medicine Acupuncture |
| title | Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort |
| title_full | Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort |
| title_fullStr | Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort |
| title_full_unstemmed | Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort |
| title_short | Patients Receiving Integrative Medicine Effectiveness Registry (PRIMIER) of the BraveNet practice-based research network: Outcomes of the PRIMIER cohort |
| title_sort | patients receiving integrative medicine effectiveness registry primier of the bravenet practice based research network outcomes of the primier cohort |
| topic | Observational Study Practice-Based Research Stress PROMIS Integrative Medicine Acupuncture |
| url | http://www.sciencedirect.com/science/article/pii/S0965229922001078 |
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