Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions
Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that astrocytes in the spinal dorsal horn (SDH) become reacti...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
|
| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S134786132030075X |
| _version_ | 1819021937026793472 |
|---|---|
| author | Miho Shiratori-Hayashi Makoto Tsuda |
| author_facet | Miho Shiratori-Hayashi Makoto Tsuda |
| author_sort | Miho Shiratori-Hayashi |
| collection | DOAJ |
| description | Astrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that astrocytes in the spinal dorsal horn (SDH) become reactive in a transcription factor signal transducer and activator of transcription 3-dependent manner without neuronal damage under chronic itch conditions, causing release of the factor lipocalin-2, leading to induction of sensitization of gastrin releasing peptide-induced chemical itch signaling in the SDH. In this review, we describe recent advances in our understanding of SDH neuronal pathways for itch transmission, the mechanisms of SDH astrocytic activation and its contribution to abnormal itch processing and discuss the role of reactive astrocytes in the SDH in abnormal sensory processing under chronic itch conditions. |
| first_indexed | 2024-12-21T04:15:02Z |
| format | Article |
| id | doaj.art-f0b56317277d4eb9b8d8de0f0f5d6979 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-21T04:15:02Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-f0b56317277d4eb9b8d8de0f0f5d69792022-12-21T19:16:21ZengElsevierJournal of Pharmacological Sciences1347-86132020-11-011443147150Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditionsMiho Shiratori-Hayashi0Makoto Tsuda1Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanCorresponding author. Fax: +81 92 642 6566.; Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanAstrocytes are the most abundant glial cells in the central nervous system (CNS), including the spinal cord. Neuronal damage induces astrocytes to become reactive and contribute to various CNS pathologies. Recent studies have demonstrated that astrocytes in the spinal dorsal horn (SDH) become reactive in a transcription factor signal transducer and activator of transcription 3-dependent manner without neuronal damage under chronic itch conditions, causing release of the factor lipocalin-2, leading to induction of sensitization of gastrin releasing peptide-induced chemical itch signaling in the SDH. In this review, we describe recent advances in our understanding of SDH neuronal pathways for itch transmission, the mechanisms of SDH astrocytic activation and its contribution to abnormal itch processing and discuss the role of reactive astrocytes in the SDH in abnormal sensory processing under chronic itch conditions.http://www.sciencedirect.com/science/article/pii/S134786132030075XAstrocytesReactive astrocytesSpinal dorsal hornChronic itchCentral sensitization of itch |
| spellingShingle | Miho Shiratori-Hayashi Makoto Tsuda Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions Journal of Pharmacological Sciences Astrocytes Reactive astrocytes Spinal dorsal horn Chronic itch Central sensitization of itch |
| title | Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions |
| title_full | Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions |
| title_fullStr | Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions |
| title_full_unstemmed | Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions |
| title_short | Role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions |
| title_sort | role of reactive astrocytes in the spinal dorsal horn under chronic itch conditions |
| topic | Astrocytes Reactive astrocytes Spinal dorsal horn Chronic itch Central sensitization of itch |
| url | http://www.sciencedirect.com/science/article/pii/S134786132030075X |
| work_keys_str_mv | AT mihoshiratorihayashi roleofreactiveastrocytesinthespinaldorsalhornunderchronicitchconditions AT makototsuda roleofreactiveastrocytesinthespinaldorsalhornunderchronicitchconditions |