Clinical application and detection techniques of liquid biopsy in gastric cancer
Abstract Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, and treatment relies on surgical resection or chemotherapy. However, traditional ex...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-023-01715-z |
| _version_ | 1797952660354105344 |
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| author | Shuo Ma Meiling Zhou Yanhua Xu Xinliang Gu Mingyuan Zou Gulinaizhaer Abudushalamu Yuming Yao Xiaobo Fan Guoqiu Wu |
| author_facet | Shuo Ma Meiling Zhou Yanhua Xu Xinliang Gu Mingyuan Zou Gulinaizhaer Abudushalamu Yuming Yao Xiaobo Fan Guoqiu Wu |
| author_sort | Shuo Ma |
| collection | DOAJ |
| description | Abstract Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, and treatment relies on surgical resection or chemotherapy. However, traditional examination and treatment methods are more harmful to patients and less sensitive and accurate. A minimally invasive method to respond to GC early screening, prognosis monitoring, treatment efficacy, and drug resistance situations is urgently needed. As a result, liquid biopsy techniques have received much attention in the clinical application of GC. The non-invasive liquid biopsy technique requires fewer samples, is reproducible, and can guide individualized patient treatment by monitoring patients' molecular-level changes in real-time. In this review, we introduced the clinical applications of circulating tumor cells, circulating free DNA, circulating tumor DNA, non-coding RNAs, exosomes, and proteins, which are the primary markers in liquid biopsy technology in GC. We also discuss the current limitations and future trends of liquid biopsy technology as applied to early clinical biopsy technology. |
| first_indexed | 2024-04-10T22:49:56Z |
| format | Article |
| id | doaj.art-f0b6d67f4c9945f7be6379401fad806d |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-10T22:49:56Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-f0b6d67f4c9945f7be6379401fad806d2023-01-15T12:05:58ZengBMCMolecular Cancer1476-45982023-01-0122112310.1186/s12943-023-01715-zClinical application and detection techniques of liquid biopsy in gastric cancerShuo Ma0Meiling Zhou1Yanhua Xu2Xinliang Gu3Mingyuan Zou4Gulinaizhaer Abudushalamu5Yuming Yao6Xiaobo Fan7Guoqiu Wu8Center of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityDepartment of Laboratory Medicine, Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityDepartment of Laboratory Medicine, Medical School, Affiliated Hospital of Nantong University, Nantong UniversityCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityCenter of Clinical Laboratory Medicine, Zhongda Hospital, Southeast UniversityAbstract Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, and treatment relies on surgical resection or chemotherapy. However, traditional examination and treatment methods are more harmful to patients and less sensitive and accurate. A minimally invasive method to respond to GC early screening, prognosis monitoring, treatment efficacy, and drug resistance situations is urgently needed. As a result, liquid biopsy techniques have received much attention in the clinical application of GC. The non-invasive liquid biopsy technique requires fewer samples, is reproducible, and can guide individualized patient treatment by monitoring patients' molecular-level changes in real-time. In this review, we introduced the clinical applications of circulating tumor cells, circulating free DNA, circulating tumor DNA, non-coding RNAs, exosomes, and proteins, which are the primary markers in liquid biopsy technology in GC. We also discuss the current limitations and future trends of liquid biopsy technology as applied to early clinical biopsy technology.https://doi.org/10.1186/s12943-023-01715-zGastric cancerLiquid biopsyCirculating tumor cellsCirculating tumor DNANon-coding RNAsExosomes |
| spellingShingle | Shuo Ma Meiling Zhou Yanhua Xu Xinliang Gu Mingyuan Zou Gulinaizhaer Abudushalamu Yuming Yao Xiaobo Fan Guoqiu Wu Clinical application and detection techniques of liquid biopsy in gastric cancer Molecular Cancer Gastric cancer Liquid biopsy Circulating tumor cells Circulating tumor DNA Non-coding RNAs Exosomes |
| title | Clinical application and detection techniques of liquid biopsy in gastric cancer |
| title_full | Clinical application and detection techniques of liquid biopsy in gastric cancer |
| title_fullStr | Clinical application and detection techniques of liquid biopsy in gastric cancer |
| title_full_unstemmed | Clinical application and detection techniques of liquid biopsy in gastric cancer |
| title_short | Clinical application and detection techniques of liquid biopsy in gastric cancer |
| title_sort | clinical application and detection techniques of liquid biopsy in gastric cancer |
| topic | Gastric cancer Liquid biopsy Circulating tumor cells Circulating tumor DNA Non-coding RNAs Exosomes |
| url | https://doi.org/10.1186/s12943-023-01715-z |
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