Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil
Bispyribac sodium is commonly used as a herbicide worldwide. Few studies had investigated the health impact of exposure to it. Redox homeostasis has a great role during organogenesis through in cell growth, differentiation, and death. The aim of this study is to investigate the redox homeostasis imb...
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| Format: | Article |
| Language: | English |
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Egyptian Society of Biological Sciences
2020-09-01
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| Series: | Egyptian Academic Journal of Biological Sciences. F, Toxicology and Pest Control |
| Subjects: | |
| Online Access: | https://eajbsf.journals.ekb.eg/article_113419_4ead23435b14eea8b96f0b43edbeb2c5.pdf |
| _version_ | 1819005202404999168 |
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| author | Sanaa, M. Abdulrhman Nahas, A. A. Reem, M. Ziada |
| author_facet | Sanaa, M. Abdulrhman Nahas, A. A. Reem, M. Ziada |
| author_sort | Sanaa, M. Abdulrhman |
| collection | DOAJ |
| description | Bispyribac sodium is commonly used as a herbicide worldwide. Few studies had investigated the health impact of exposure to it. Redox homeostasis has a great role during organogenesis through in cell growth, differentiation, and death. The aim of this study is to investigate the redox homeostasis imbalance and teratogenic effect of BPS in female rats exposed to bispyribac sodium (BPS) during organogenesis and evaluates the protective role of Nigella Sativa Oil (NSO). Pregnant female rats were grouped into four groups, negative and positive (NSO) control groups. While the others, BPS with and without NSO treatment groups. Results showed that BPS exposure during the pregnancy led to maternal and fetotoxicity as evidenced by preimplantation, post-implantation loss, reduction in placenta weight, reduction in fetal weight, fetal length, skeletal anomalies (incomplete ossification, misaligned sternbrae), visceral malformation (anophthalmia, microphthalmia, internal hydrocephaly, and microcephaly) and oxidative stress in dams serum. NSO treatment exhibited amelioration in the aforementioned maternal and fetotoxicity against BPS exposure. |
| first_indexed | 2024-12-20T23:49:02Z |
| format | Article |
| id | doaj.art-f0b711b0f77246d2936f3e70d83bc0cb |
| institution | Directory Open Access Journal |
| issn | 2090-0864 2090-0791 |
| language | English |
| last_indexed | 2024-12-20T23:49:02Z |
| publishDate | 2020-09-01 |
| publisher | Egyptian Society of Biological Sciences |
| record_format | Article |
| series | Egyptian Academic Journal of Biological Sciences. F, Toxicology and Pest Control |
| spelling | doaj.art-f0b711b0f77246d2936f3e70d83bc0cb2022-12-21T19:22:53ZengEgyptian Society of Biological SciencesEgyptian Academic Journal of Biological Sciences. F, Toxicology and Pest Control2090-08642090-07912020-09-0112297108DOI:10.21608/EAJBSF.2020.113419Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa OilSanaa, M. Abdulrhman0 Nahas, A. A.1Reem, M. Ziada2Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab. (CAPL), Agricultural Research Center, Ministry of Agriculture, Dokki, Giza 12618, EgyptMammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab. (CAPL), Agricultural Research Center, Ministry of Agriculture, Dokki, Giza 12618, EgyptMammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab. (CAPL), Agricultural Research Center, Ministry of Agriculture, Dokki, Giza 12618, EgyptBispyribac sodium is commonly used as a herbicide worldwide. Few studies had investigated the health impact of exposure to it. Redox homeostasis has a great role during organogenesis through in cell growth, differentiation, and death. The aim of this study is to investigate the redox homeostasis imbalance and teratogenic effect of BPS in female rats exposed to bispyribac sodium (BPS) during organogenesis and evaluates the protective role of Nigella Sativa Oil (NSO). Pregnant female rats were grouped into four groups, negative and positive (NSO) control groups. While the others, BPS with and without NSO treatment groups. Results showed that BPS exposure during the pregnancy led to maternal and fetotoxicity as evidenced by preimplantation, post-implantation loss, reduction in placenta weight, reduction in fetal weight, fetal length, skeletal anomalies (incomplete ossification, misaligned sternbrae), visceral malformation (anophthalmia, microphthalmia, internal hydrocephaly, and microcephaly) and oxidative stress in dams serum. NSO treatment exhibited amelioration in the aforementioned maternal and fetotoxicity against BPS exposure.https://eajbsf.journals.ekb.eg/article_113419_4ead23435b14eea8b96f0b43edbeb2c5.pdffetotoxicity; maternal toxicity; bispyribac sodium; nigella sativa oil; oxidative stress |
| spellingShingle | Sanaa, M. Abdulrhman Nahas, A. A. Reem, M. Ziada Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil Egyptian Academic Journal of Biological Sciences. F, Toxicology and Pest Control fetotoxicity; maternal toxicity; bispyribac sodium; nigella sativa oil; oxidative stress |
| title | Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil |
| title_full | Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil |
| title_fullStr | Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil |
| title_full_unstemmed | Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil |
| title_short | Pregnancy Outcome in Female Rats Exposed to Bispyribac Sodium and Ameliorative Effect of Nigella Sativa Oil |
| title_sort | pregnancy outcome in female rats exposed to bispyribac sodium and ameliorative effect of nigella sativa oil |
| topic | fetotoxicity; maternal toxicity; bispyribac sodium; nigella sativa oil; oxidative stress |
| url | https://eajbsf.journals.ekb.eg/article_113419_4ead23435b14eea8b96f0b43edbeb2c5.pdf |
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