CTCF and cellular heterogeneity
Abstract Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes. Different cells display substantial v...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-10-01
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| Series: | Cell & Bioscience |
| Online Access: | http://link.springer.com/article/10.1186/s13578-019-0347-2 |
| _version_ | 1828893547726635008 |
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| author | Gang Ren Keji Zhao |
| author_facet | Gang Ren Keji Zhao |
| author_sort | Gang Ren |
| collection | DOAJ |
| description | Abstract Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes. Different cells display substantial variation in gene expression and in response to environmental signaling even in an apparently homogeneous population of cells. Recent studies started to reveal the underlying mechanisms for cellular heterogeneity, particularly related to the states of chromatin. Accumulating evidence suggests that CTCF, an important factor regulating chromatin organization, plays a key role in the control of gene expression variation by stabilizing enhancer–promoter interaction. |
| first_indexed | 2024-12-13T13:56:30Z |
| format | Article |
| id | doaj.art-f0b78caee05c460496a837f5f0c3e45c |
| institution | Directory Open Access Journal |
| issn | 2045-3701 |
| language | English |
| last_indexed | 2024-12-13T13:56:30Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj.art-f0b78caee05c460496a837f5f0c3e45c2022-12-21T23:42:54ZengBMCCell & Bioscience2045-37012019-10-01911710.1186/s13578-019-0347-2CTCF and cellular heterogeneityGang Ren0Keji Zhao1Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of HealthLaboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of HealthAbstract Cellular heterogeneity, which was initially defined for tumor cells, is a fundamental property of all cellular systems, ranging from genetic diversity to cell-to-cell variation driven by stochastic molecular interactions involved all cellular processes. Different cells display substantial variation in gene expression and in response to environmental signaling even in an apparently homogeneous population of cells. Recent studies started to reveal the underlying mechanisms for cellular heterogeneity, particularly related to the states of chromatin. Accumulating evidence suggests that CTCF, an important factor regulating chromatin organization, plays a key role in the control of gene expression variation by stabilizing enhancer–promoter interaction.http://link.springer.com/article/10.1186/s13578-019-0347-2 |
| spellingShingle | Gang Ren Keji Zhao CTCF and cellular heterogeneity Cell & Bioscience |
| title | CTCF and cellular heterogeneity |
| title_full | CTCF and cellular heterogeneity |
| title_fullStr | CTCF and cellular heterogeneity |
| title_full_unstemmed | CTCF and cellular heterogeneity |
| title_short | CTCF and cellular heterogeneity |
| title_sort | ctcf and cellular heterogeneity |
| url | http://link.springer.com/article/10.1186/s13578-019-0347-2 |
| work_keys_str_mv | AT gangren ctcfandcellularheterogeneity AT kejizhao ctcfandcellularheterogeneity |