Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy.

Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy.

Triple therapy of chronic hepatitis C virus (HCV) infection with boceprevir (BOC) or telaprevir (TVR) leads to virologic failure in many patients which is often associated with the selection of resistance-associated variants (RAVs). These resistance profiles are of importance for the selection of po...

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Main Authors: Julia Dietz, Daniel Rupp, Simone Susser, Johannes Vermehren, Kai-Henrik Peiffer, Natalie Filmann, Dimitra Bon, Thomas Kuntzen, Stefan Mauss, Georgios Grammatikos, Dany Perner, Caterina Berkowski, Eva Herrmann, Stefan Zeuzem, Ralf Bartenschlager, Christoph Sarrazin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4900565?pdf=render

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