Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women
Abstract Objective To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. Methods A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected us...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
|
| Series: | Aging Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/agm2.12207 |
| _version_ | 1811229962197270528 |
|---|---|
| author | Shuang Li Yi Wang Jieyu He Wu Huang Eryuan Liao Youshuo Liu Junkun Zhan Yanjiao Wang |
| author_facet | Shuang Li Yi Wang Jieyu He Wu Huang Eryuan Liao Youshuo Liu Junkun Zhan Yanjiao Wang |
| author_sort | Shuang Li |
| collection | DOAJ |
| description | Abstract Objective To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. Methods A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected using a standardized questionnaire. Measures of body composition were obtained using dual X‐ray absorptiometry. Body lean mass and fat mass indices were calculated by dividing total body lean/fat weight (kg) by body height squared (kg/m2). Blood samples were collected to assess liver and renal functions and lipid profiles. Analysis of variance, Pearson correlations, and multiple regression were used to analyze the associations between serum ALT and body composition. Results We found negative relationships of serum ALT with age, menopause duration, and serum HDL‐C levels. Serum ALT was positively correlated with BMI, serum TG levels, and the lean mass index and fat mass index. In a multivariate model adjusted for age, menopause duration, serum TG, and HDL‐C levels, a 1‐unit increase in the fat mass index was associated with a 0.176 U/L increase in ALT (95% CI 0.020 to 0.050, P < 0.001). Conclusion Serum ALT was positively associated with the body fat mass index of postmenopausal women in China. |
| first_indexed | 2024-04-12T10:20:59Z |
| format | Article |
| id | doaj.art-f0b9c6398b194a93838d20aa537725d1 |
| institution | Directory Open Access Journal |
| issn | 2475-0360 |
| language | English |
| last_indexed | 2024-04-12T10:20:59Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aging Medicine |
| spelling | doaj.art-f0b9c6398b194a93838d20aa537725d12022-12-22T03:37:05ZengWileyAging Medicine2475-03602022-06-015210110510.1002/agm2.12207Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese womenShuang Li0Yi Wang1Jieyu He2Wu Huang3Eryuan Liao4Youshuo Liu5Junkun Zhan6Yanjiao Wang7Department of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Endocrinology, National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaDepartment of Geriatrics, Institute of Aging and Geriatrics, The Second Xiangya Hospital Central South University Changsha ChinaAbstract Objective To investigate the relationships between serum alanine aminotransferase (ALT) and body composition among postmenopausal women in China. Methods A cross‐sectional study was conducted with 776 postmenopausal women in China from May to July 2008. Clinical information was collected using a standardized questionnaire. Measures of body composition were obtained using dual X‐ray absorptiometry. Body lean mass and fat mass indices were calculated by dividing total body lean/fat weight (kg) by body height squared (kg/m2). Blood samples were collected to assess liver and renal functions and lipid profiles. Analysis of variance, Pearson correlations, and multiple regression were used to analyze the associations between serum ALT and body composition. Results We found negative relationships of serum ALT with age, menopause duration, and serum HDL‐C levels. Serum ALT was positively correlated with BMI, serum TG levels, and the lean mass index and fat mass index. In a multivariate model adjusted for age, menopause duration, serum TG, and HDL‐C levels, a 1‐unit increase in the fat mass index was associated with a 0.176 U/L increase in ALT (95% CI 0.020 to 0.050, P < 0.001). Conclusion Serum ALT was positively associated with the body fat mass index of postmenopausal women in China.https://doi.org/10.1002/agm2.12207alanine aminotransferasebody compositionpostmenopausal women |
| spellingShingle | Shuang Li Yi Wang Jieyu He Wu Huang Eryuan Liao Youshuo Liu Junkun Zhan Yanjiao Wang Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women Aging Medicine alanine aminotransferase body composition postmenopausal women |
| title | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
| title_full | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
| title_fullStr | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
| title_full_unstemmed | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
| title_short | Analysis of the relationship between serum alanine aminotransferase and body composition in Chinese women |
| title_sort | analysis of the relationship between serum alanine aminotransferase and body composition in chinese women |
| topic | alanine aminotransferase body composition postmenopausal women |
| url | https://doi.org/10.1002/agm2.12207 |
| work_keys_str_mv | AT shuangli analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT yiwang analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT jieyuhe analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT wuhuang analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT eryuanliao analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT youshuoliu analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT junkunzhan analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen AT yanjiaowang analysisoftherelationshipbetweenserumalanineaminotransferaseandbodycompositioninchinesewomen |