Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization
Abstract Background Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction system is incomplete yet. We investigated short-term effects of particulate...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Particle and Fibre Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12989-018-0275-z |
| _version_ | 1818129015257432064 |
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| author | Siqi Zhang Susanne Breitner Wayne E Cascio Robert B Devlin Lucas M Neas David Diaz-Sanchez William E Kraus Joel Schwartz Elizabeth R Hauser Annette Peters Alexandra Schneider |
| author_facet | Siqi Zhang Susanne Breitner Wayne E Cascio Robert B Devlin Lucas M Neas David Diaz-Sanchez William E Kraus Joel Schwartz Elizabeth R Hauser Annette Peters Alexandra Schneider |
| author_sort | Siqi Zhang |
| collection | DOAJ |
| description | Abstract Background Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction system is incomplete yet. We investigated short-term effects of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3) on cardiac electrical impulse propagation and repolarization as recorded in surface electrocardiograms (ECG). Methods We analyzed repeated 12-lead ECG measurements performed on 5,332 patients between 2001 and 2012. The participants came from the Duke CATHGEN Study who underwent cardiac catheterization and resided in North Carolina, United States (NC, U.S.). Daily concentrations of PM2.5 and O3 at each participant’s home address were predicted with a hybrid air quality exposure model. We used generalized additive mixed models to investigate the associations of PM2.5 and O3 with the PR interval, QRS interval, heart rate-corrected QT interval (QTc), and heart rate (HR). The temporal lag structures of the associations were examined using distributed-lag models. Results Elevated PM2.5 and O3 were associated with four-day lagged lengthening of the PR and QRS intervals, and with one-day lagged increases in HR. We observed immediate effects on the lengthening of the QTc interval for both PM2.5 and O3, as well as delayed effects for PM2.5 (lagged by 3 – 4 days). The associations of PM2.5 and O3 with the PR interval and the association of O3 with the QRS interval persisted until up to seven days after exposure. Conclusions In patients undergoing cardiac catheterization, short-term exposure to air pollution was associated with increased HR and delays in atrioventricular conduction, ventricular depolarization and repolarization. |
| first_indexed | 2024-12-11T07:42:25Z |
| format | Article |
| id | doaj.art-f0b9f40a66114c34b6ba30013cf9400b |
| institution | Directory Open Access Journal |
| issn | 1743-8977 |
| language | English |
| last_indexed | 2024-12-11T07:42:25Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Particle and Fibre Toxicology |
| spelling | doaj.art-f0b9f40a66114c34b6ba30013cf9400b2022-12-22T01:15:32ZengBMCParticle and Fibre Toxicology1743-89772018-10-011511910.1186/s12989-018-0275-zShort-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterizationSiqi Zhang0Susanne Breitner1Wayne E Cascio2Robert B Devlin3Lucas M Neas4David Diaz-Sanchez5William E Kraus6Joel Schwartz7Elizabeth R Hauser8Annette Peters9Alexandra Schneider10Institute of Epidemiology, Helmholtz Zentrum MünchenInstitute of Epidemiology, Helmholtz Zentrum MünchenNational Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle ParkNational Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle ParkNational Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle ParkNational Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle ParkDuke Molecular Physiology Institute, School of Medicine, Duke UniversityDepartment of Environmental Health, Harvard T.H. Chan School of Public HealthDuke Molecular Physiology Institute, School of Medicine, Duke UniversityInstitute of Epidemiology, Helmholtz Zentrum MünchenInstitute of Epidemiology, Helmholtz Zentrum MünchenAbstract Background Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction system is incomplete yet. We investigated short-term effects of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3) on cardiac electrical impulse propagation and repolarization as recorded in surface electrocardiograms (ECG). Methods We analyzed repeated 12-lead ECG measurements performed on 5,332 patients between 2001 and 2012. The participants came from the Duke CATHGEN Study who underwent cardiac catheterization and resided in North Carolina, United States (NC, U.S.). Daily concentrations of PM2.5 and O3 at each participant’s home address were predicted with a hybrid air quality exposure model. We used generalized additive mixed models to investigate the associations of PM2.5 and O3 with the PR interval, QRS interval, heart rate-corrected QT interval (QTc), and heart rate (HR). The temporal lag structures of the associations were examined using distributed-lag models. Results Elevated PM2.5 and O3 were associated with four-day lagged lengthening of the PR and QRS intervals, and with one-day lagged increases in HR. We observed immediate effects on the lengthening of the QTc interval for both PM2.5 and O3, as well as delayed effects for PM2.5 (lagged by 3 – 4 days). The associations of PM2.5 and O3 with the PR interval and the association of O3 with the QRS interval persisted until up to seven days after exposure. Conclusions In patients undergoing cardiac catheterization, short-term exposure to air pollution was associated with increased HR and delays in atrioventricular conduction, ventricular depolarization and repolarization.http://link.springer.com/article/10.1186/s12989-018-0275-zAir pollutionElectrocardiogramPR intervalQT intervalQRS interval |
| spellingShingle | Siqi Zhang Susanne Breitner Wayne E Cascio Robert B Devlin Lucas M Neas David Diaz-Sanchez William E Kraus Joel Schwartz Elizabeth R Hauser Annette Peters Alexandra Schneider Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization Particle and Fibre Toxicology Air pollution Electrocardiogram PR interval QT interval QRS interval |
| title | Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization |
| title_full | Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization |
| title_fullStr | Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization |
| title_full_unstemmed | Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization |
| title_short | Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization |
| title_sort | short term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization |
| topic | Air pollution Electrocardiogram PR interval QT interval QRS interval |
| url | http://link.springer.com/article/10.1186/s12989-018-0275-z |
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