Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
The cryo-EM structure of the IscB–ωRNA–target DNA complex provide insights into the ωRNA-guided DNA cleavage mechanism by IscB and the evolution of the type II CRISPR-Cas9 effector complexes
Bibliographic Details
| Main Authors: |
Kazuki Kato,
Sae Okazaki,
Soumya Kannan,
Han Altae-Tran,
F. Esra Demircioglu,
Yukari Isayama,
Junichiro Ishikawa,
Masahiro Fukuda,
Rhiannon K. Macrae,
Tomohiro Nishizawa,
Kira S. Makarova,
Eugene V. Koonin,
Feng Zhang,
Hiroshi Nishimasu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34378-3
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