Lactose Engineering for Better Performance in Dry Powder Inhalers
Dry powder inhaler (DPI) is generally formulated as a powder mixture of coarse carrier particles and micronized drug with aerodynamic diameters of 1-5 μm. Carrier particles are used to improve drug particle flowability, thus improving dosing accuracy, minimizing the dose variability compared with dr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2012-08-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-183.pdf |
| _version_ | 1811315256081776640 |
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| author | Yahya Rahimpour Hamed Hamishehkar |
| author_facet | Yahya Rahimpour Hamed Hamishehkar |
| author_sort | Yahya Rahimpour |
| collection | DOAJ |
| description | Dry powder inhaler (DPI) is generally formulated as a powder mixture of coarse carrier particles and micronized drug with aerodynamic diameters of 1-5 μm. Carrier particles are used to improve drug particle flowability, thus improving dosing accuracy, minimizing the dose variability compared with drug alone and making them easier to handle during manufacturing operations. Lactose is the most common and frequently used carrier in DPIs formulations and nowadays various inhalation grades of lactose with different physico-chemical properties are available on the market. Therefore, the purpose of this manuscript is to review evolution of lactose as a carrier in inhalable formulations, their production and the impact of its physico-chemical properties on drug dispersion. This review offers a perspective on the current reported studies to modify lactose for better performance in DPIs. |
| first_indexed | 2024-04-13T11:27:01Z |
| format | Article |
| id | doaj.art-f0ba7a47920f49fb957b67ba8f942bce |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-13T11:27:01Z |
| publishDate | 2012-08-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-f0ba7a47920f49fb957b67ba8f942bce2022-12-22T02:48:41ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082012-08-0122183187Lactose Engineering for Better Performance in Dry Powder InhalersYahya RahimpourHamed HamishehkarDry powder inhaler (DPI) is generally formulated as a powder mixture of coarse carrier particles and micronized drug with aerodynamic diameters of 1-5 μm. Carrier particles are used to improve drug particle flowability, thus improving dosing accuracy, minimizing the dose variability compared with drug alone and making them easier to handle during manufacturing operations. Lactose is the most common and frequently used carrier in DPIs formulations and nowadays various inhalation grades of lactose with different physico-chemical properties are available on the market. Therefore, the purpose of this manuscript is to review evolution of lactose as a carrier in inhalable formulations, their production and the impact of its physico-chemical properties on drug dispersion. This review offers a perspective on the current reported studies to modify lactose for better performance in DPIs.http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-183.pdfCarrierDry powder inhalerPulmonary drug deliveryLactose |
| spellingShingle | Yahya Rahimpour Hamed Hamishehkar Lactose Engineering for Better Performance in Dry Powder Inhalers Advanced Pharmaceutical Bulletin Carrier Dry powder inhaler Pulmonary drug delivery Lactose |
| title | Lactose Engineering for Better Performance in Dry Powder Inhalers |
| title_full | Lactose Engineering for Better Performance in Dry Powder Inhalers |
| title_fullStr | Lactose Engineering for Better Performance in Dry Powder Inhalers |
| title_full_unstemmed | Lactose Engineering for Better Performance in Dry Powder Inhalers |
| title_short | Lactose Engineering for Better Performance in Dry Powder Inhalers |
| title_sort | lactose engineering for better performance in dry powder inhalers |
| topic | Carrier Dry powder inhaler Pulmonary drug delivery Lactose |
| url | http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-2-183.pdf |
| work_keys_str_mv | AT yahyarahimpour lactoseengineeringforbetterperformanceindrypowderinhalers AT hamedhamishehkar lactoseengineeringforbetterperformanceindrypowderinhalers |