Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose

BACKGROUND: Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear. OBJECTIVES: The purpose of this...

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Main Authors: Young-Mi Eun, Sung-Goo Kang, Sang-Wook Song
Format: Article
Language:English
Published: King Faisal Specialist Hospital and Research Centre 2016-09-01
Series:Annals of Saudi Medicine
Online Access:https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2016.334
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author Young-Mi Eun
Sung-Goo Kang
Sang-Wook Song
author_facet Young-Mi Eun
Sung-Goo Kang
Sang-Wook Song
author_sort Young-Mi Eun
collection DOAJ
description BACKGROUND: Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear. OBJECTIVES: The purpose of this study was to compare the coronary artery calcium (CAC) scores of participants with normal fasting glucose versus those with IFG, according to fasting plasma glucose (FPG) levels, and to assess whether differences in CAC scores were independent of important confounders. DESIGN: Retrospective study. SETTING: Health Promotion Center of the University Hospital (Gyeonggi-do, South Korea), during the period 2010–2014. PATIENTS AND METHODS: Participants were enrolled from the general population who visited for a medical check-up. CAC was assessed in asymptomatic individuals by multidetector computed tomography. Anthropometric parameters and metabolic profiles were also recorded. Subjects were divided into four fasting glucose groups. Participants with a history of CVD or diabetes mellitus were excluded. MAIN OUTCOME MEASURES: Correlation between FPG and CAC scores, CAC score categories, and association between CAC score and FPG categories. RESULTS: Of 1112 participants, 346 (34.2%) had a CAC score >0. FPG values in the IFG patients were positively but weakly correlated with CAC scores (r=0.099, P=.001). The incidence of CAC differed according to FPG level (P<.001) and in Kruskal-Wallis test the mean CAC score differed by FPG group (P<.001). After adjustment for other factors in a multiple logistic regression analysis, those subjects with FPG ≥110 mg/dL had a significantly higher risk of CAC than did subjects with normal fasting glucose (110≤FPG [mg/dL] <120, OR=2.507, P=.002; 120≤FPG [mg/dL] <126, OR=3.568, P=.001 vs. <100 mg/dL) CONCLUSION: IFG (especially FPG≥110 mg/dL) could be an independent risk factor for CAC. These associations were not altered after adjustment for other possible confounders. LIMITATIONS: Possible misclassification because data taken from a single blood test. No HbA1c tests or repeated FPG tests. No adjustment for other potentially important confounders.
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spelling doaj.art-f0bbd11d70364ff1a0d5ce452ee6a10a2022-12-21T19:09:09ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662016-09-0136533434010.5144/0256-4947.2016.334asm-5-334Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucoseYoung-Mi Eun0Sung-Goo Kang1Sang-Wook Song2From the Department of Family Medicine, St. Vincent's Hospital, Suwon, South KoreaFrom the Department of Family Medicine, St. Vincent's Hospital, Suwon, South KoreaFrom the Department of Family Medicine, St. Vincent's Hospital, Suwon, South KoreaBACKGROUND: Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear. OBJECTIVES: The purpose of this study was to compare the coronary artery calcium (CAC) scores of participants with normal fasting glucose versus those with IFG, according to fasting plasma glucose (FPG) levels, and to assess whether differences in CAC scores were independent of important confounders. DESIGN: Retrospective study. SETTING: Health Promotion Center of the University Hospital (Gyeonggi-do, South Korea), during the period 2010–2014. PATIENTS AND METHODS: Participants were enrolled from the general population who visited for a medical check-up. CAC was assessed in asymptomatic individuals by multidetector computed tomography. Anthropometric parameters and metabolic profiles were also recorded. Subjects were divided into four fasting glucose groups. Participants with a history of CVD or diabetes mellitus were excluded. MAIN OUTCOME MEASURES: Correlation between FPG and CAC scores, CAC score categories, and association between CAC score and FPG categories. RESULTS: Of 1112 participants, 346 (34.2%) had a CAC score >0. FPG values in the IFG patients were positively but weakly correlated with CAC scores (r=0.099, P=.001). The incidence of CAC differed according to FPG level (P<.001) and in Kruskal-Wallis test the mean CAC score differed by FPG group (P<.001). After adjustment for other factors in a multiple logistic regression analysis, those subjects with FPG ≥110 mg/dL had a significantly higher risk of CAC than did subjects with normal fasting glucose (110≤FPG [mg/dL] <120, OR=2.507, P=.002; 120≤FPG [mg/dL] <126, OR=3.568, P=.001 vs. <100 mg/dL) CONCLUSION: IFG (especially FPG≥110 mg/dL) could be an independent risk factor for CAC. These associations were not altered after adjustment for other possible confounders. LIMITATIONS: Possible misclassification because data taken from a single blood test. No HbA1c tests or repeated FPG tests. No adjustment for other potentially important confounders.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2016.334
spellingShingle Young-Mi Eun
Sung-Goo Kang
Sang-Wook Song
Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
Annals of Saudi Medicine
title Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
title_full Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
title_fullStr Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
title_full_unstemmed Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
title_short Fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
title_sort fasting plasma glucose levels and coronary artery calcification in subjects with impaired fasting glucose
url https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2016.334
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