What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases
Purpose To identify candidate factors for predicting high-volume lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC). Methods We retrospectively studied 2981 patients with PTMC who underwent thyroidectomy from 2013 to 2016. LLNM was identified by histopathology. Patients...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-07-01
|
| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2022.2075494 |
| _version_ | 1797684512258260992 |
|---|---|
| author | Luying Gao Xiaoyi Li Chunhao Liu Ruifeng Liu Xinlong Shi Liyuan Ma Hao Zhao Yu Xia Yuxin Jiang |
| author_facet | Luying Gao Xiaoyi Li Chunhao Liu Ruifeng Liu Xinlong Shi Liyuan Ma Hao Zhao Yu Xia Yuxin Jiang |
| author_sort | Luying Gao |
| collection | DOAJ |
| description | Purpose To identify candidate factors for predicting high-volume lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC). Methods We retrospectively studied 2981 patients with PTMC who underwent thyroidectomy from 2013 to 2016. LLNM was identified by histopathology. Patients with different LLNM statuses were compared according to clinical, sonographic and pathological parameters. A multivariate logistic model was established to predict high-volume LLNM (number of metastatic lymph nodes >5). Results High-volume LLNM of PTMC was independently associated with age < 40 years (OR = 1.791, P = 0.023), male sex (OR = 2.401, p = 0.001), tumor size > 0.5 cm (OR = 4.839, p < 0.001), extrathyroidal extension (OR = 2.097, p = 0.007) and microcalcification (OR = 2.894, p = 0.002). These five factors were incorporated together to develop a multivariate analysis, which showed good predictive ability (AUC = 0.78, 95% CI 0.72–0.83), with a sensitivity of 80.0% and a specificity of 61.4%. Moreover, more level II or V lateral regions were involved in patients with high-volume LLNM than in those with small-volume LLNM (69.2% vs. 25.0%, p < 0.001; 10.8% vs. 4.7%, p < 0.001). Conclusion Multilevel LLNM tended to be more common in patients with PTMC who had high-volume LLNM. The high-volume LLNM rates of patients with PTMC with age < 40 years, male sex, tumor size > 0.5 cm, extrathyroidal extension and microcalcification were relatively higher than those without. These findings may be useful for identifying patients at higher high-volume LLNM risk who may require more aggressive treatment or intensive follow-up management. |
| first_indexed | 2024-03-12T00:30:43Z |
| format | Article |
| id | doaj.art-f0bc4c8fd78242b89f496ba4cbc3abeb |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:43Z |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-f0bc4c8fd78242b89f496ba4cbc3abeb2023-09-15T10:21:30ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-07-013571519152510.1080/08941939.2022.20754942075494What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive CasesLuying Gao0Xiaoyi Li1Chunhao Liu2Ruifeng Liu3Xinlong Shi4Liyuan Ma5Hao Zhao6Yu Xia7Yuxin Jiang8Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegePurpose To identify candidate factors for predicting high-volume lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC). Methods We retrospectively studied 2981 patients with PTMC who underwent thyroidectomy from 2013 to 2016. LLNM was identified by histopathology. Patients with different LLNM statuses were compared according to clinical, sonographic and pathological parameters. A multivariate logistic model was established to predict high-volume LLNM (number of metastatic lymph nodes >5). Results High-volume LLNM of PTMC was independently associated with age < 40 years (OR = 1.791, P = 0.023), male sex (OR = 2.401, p = 0.001), tumor size > 0.5 cm (OR = 4.839, p < 0.001), extrathyroidal extension (OR = 2.097, p = 0.007) and microcalcification (OR = 2.894, p = 0.002). These five factors were incorporated together to develop a multivariate analysis, which showed good predictive ability (AUC = 0.78, 95% CI 0.72–0.83), with a sensitivity of 80.0% and a specificity of 61.4%. Moreover, more level II or V lateral regions were involved in patients with high-volume LLNM than in those with small-volume LLNM (69.2% vs. 25.0%, p < 0.001; 10.8% vs. 4.7%, p < 0.001). Conclusion Multilevel LLNM tended to be more common in patients with PTMC who had high-volume LLNM. The high-volume LLNM rates of patients with PTMC with age < 40 years, male sex, tumor size > 0.5 cm, extrathyroidal extension and microcalcification were relatively higher than those without. These findings may be useful for identifying patients at higher high-volume LLNM risk who may require more aggressive treatment or intensive follow-up management.http://dx.doi.org/10.1080/08941939.2022.2075494thyroid cancerultrasoundlateral lymph node metastaseshigh-volume lateral lymph node metastasespapillary thyroid microcarcinoma |
| spellingShingle | Luying Gao Xiaoyi Li Chunhao Liu Ruifeng Liu Xinlong Shi Liyuan Ma Hao Zhao Yu Xia Yuxin Jiang What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases Journal of Investigative Surgery thyroid cancer ultrasound lateral lymph node metastases high-volume lateral lymph node metastases papillary thyroid microcarcinoma |
| title | What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases |
| title_full | What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases |
| title_fullStr | What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases |
| title_full_unstemmed | What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases |
| title_short | What Are the Characteristics of Papillary Thyroid Microcarcinoma Prone to High-Volume Lateral Lymph Node Metastasis? - An Analysis of 2981 Consecutive Cases |
| title_sort | what are the characteristics of papillary thyroid microcarcinoma prone to high volume lateral lymph node metastasis an analysis of 2981 consecutive cases |
| topic | thyroid cancer ultrasound lateral lymph node metastases high-volume lateral lymph node metastases papillary thyroid microcarcinoma |
| url | http://dx.doi.org/10.1080/08941939.2022.2075494 |
| work_keys_str_mv | AT luyinggao whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT xiaoyili whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT chunhaoliu whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT ruifengliu whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT xinlongshi whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT liyuanma whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT haozhao whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT yuxia whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases AT yuxinjiang whatarethecharacteristicsofpapillarythyroidmicrocarcinomapronetohighvolumelaterallymphnodemetastasisananalysisof2981consecutivecases |