Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice
Tobacco (<i>Nicotiana tabacum</i> Linn.) is a famous traditional herb used in folk medicine. The essential oils of tobacco have been demonstrated in modern studies to possess antioxidant, anti-inflammatory, and neuroprotective properties, while its anxiolytic effect has not been reported...
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MDPI AG
2021-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/14/4171 |
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| author | Danqing Xie Lei Yao Yan Huang Shuaifan Wu Li Ma Yuhong Li Wencui Wang |
| author_facet | Danqing Xie Lei Yao Yan Huang Shuaifan Wu Li Ma Yuhong Li Wencui Wang |
| author_sort | Danqing Xie |
| collection | DOAJ |
| description | Tobacco (<i>Nicotiana tabacum</i> Linn.) is a famous traditional herb used in folk medicine. The essential oils of tobacco have been demonstrated in modern studies to possess antioxidant, anti-inflammatory, and neuroprotective properties, while its anxiolytic effect has not been reported. The purpose of this study was to evaluate the anxiolytic effect of Yunnan tobacco essential oil (YTO) and Zimbabwe tobacco essential oil (ZTO) on mice. The constituents of YTO and ZTO were analyzed by GC/MS. The anxiolytic effect of YTO and ZTO (0.1%, 1%, and 10%, <i>v</i>/<i>v</i>) on male ICR mice was evaluated in the light–dark box test (LDB) and the elevated plus maze test (EPM) test via inhalation and transdermal administration. After the behavioral tests, salivary corticosterone levels in mice were measured. The behavioral analysis showed that the administration of both YTO and ZTO elevated the time that the mice spent in the light chamber in the LDB test compared to the untreated control. In the EPM test, YTO and ZTO increased the time spent in open arms and the number of entries into the open arms. In addition, both YTO and ZTO significantly decreased salivary corticosterone levels in mice (<i>p</i> ≤ 0.001). In summary, our results demonstrated that inhalation and transdermal administration of both YTO and ZTO showed anxiolytic effect on male ICR mice. |
| first_indexed | 2024-03-10T09:31:01Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T09:31:01Z |
| publishDate | 2021-07-01 |
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| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f0bc9ba93341476e8fa8a36d26b85c152023-11-22T04:29:40ZengMDPI AGMolecules1420-30492021-07-012614417110.3390/molecules26144171Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on MiceDanqing Xie0Lei Yao1Yan Huang2Shuaifan Wu3Li Ma4Yuhong Li5Wencui Wang6Department of Landscape Architecture, School of Design, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, ChinaDepartment of Landscape Architecture, School of Design, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, ChinaHuabao Flavours & Fragrances Co., Ltd., 1299 Yecheng Road, Shanghai 201821, ChinaHuabao Flavours & Fragrances Co., Ltd., 1299 Yecheng Road, Shanghai 201821, ChinaDepartment of Landscape Architecture, School of Design, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, ChinaDepartment of Landscape Architecture, School of Design, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, ChinaDepartment of Landscape Architecture, School of Design, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai 200240, ChinaTobacco (<i>Nicotiana tabacum</i> Linn.) is a famous traditional herb used in folk medicine. The essential oils of tobacco have been demonstrated in modern studies to possess antioxidant, anti-inflammatory, and neuroprotective properties, while its anxiolytic effect has not been reported. The purpose of this study was to evaluate the anxiolytic effect of Yunnan tobacco essential oil (YTO) and Zimbabwe tobacco essential oil (ZTO) on mice. The constituents of YTO and ZTO were analyzed by GC/MS. The anxiolytic effect of YTO and ZTO (0.1%, 1%, and 10%, <i>v</i>/<i>v</i>) on male ICR mice was evaluated in the light–dark box test (LDB) and the elevated plus maze test (EPM) test via inhalation and transdermal administration. After the behavioral tests, salivary corticosterone levels in mice were measured. The behavioral analysis showed that the administration of both YTO and ZTO elevated the time that the mice spent in the light chamber in the LDB test compared to the untreated control. In the EPM test, YTO and ZTO increased the time spent in open arms and the number of entries into the open arms. In addition, both YTO and ZTO significantly decreased salivary corticosterone levels in mice (<i>p</i> ≤ 0.001). In summary, our results demonstrated that inhalation and transdermal administration of both YTO and ZTO showed anxiolytic effect on male ICR mice.https://www.mdpi.com/1420-3049/26/14/4171tobacco leafessential oilanti-anxiety effectbehavioral testssalivary corticosterone |
| spellingShingle | Danqing Xie Lei Yao Yan Huang Shuaifan Wu Li Ma Yuhong Li Wencui Wang Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice Molecules tobacco leaf essential oil anti-anxiety effect behavioral tests salivary corticosterone |
| title | Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice |
| title_full | Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice |
| title_fullStr | Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice |
| title_full_unstemmed | Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice |
| title_short | Anxiolytic Effect of Two Tobacco Essential Oils (<i>Nicotiana tabacum</i> Linn.) on Mice |
| title_sort | anxiolytic effect of two tobacco essential oils i nicotiana tabacum i linn on mice |
| topic | tobacco leaf essential oil anti-anxiety effect behavioral tests salivary corticosterone |
| url | https://www.mdpi.com/1420-3049/26/14/4171 |
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