Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma
Purpose: To compare image characteristics of retinal nerve fiber layer (RNFL) between glaucoma patients and healthy controls using adaptive optics scanning laser ophthalmoscopy (AOSLO). Methods: This was a cross-sectional pilot study with two groups: a glaucoma group with patients with moderate or s...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=8;spage=2877;epage=2882;aulast=Choudhari |
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| author | Nikhil S Choudhari Sanjay Kumar Ashutosh Richhariya Rashmi Krishnamurthy Ruchi Priya Chandra Sekhar Garudadri |
| author_facet | Nikhil S Choudhari Sanjay Kumar Ashutosh Richhariya Rashmi Krishnamurthy Ruchi Priya Chandra Sekhar Garudadri |
| author_sort | Nikhil S Choudhari |
| collection | DOAJ |
| description | Purpose: To compare image characteristics of retinal nerve fiber layer (RNFL) between glaucoma patients and healthy controls using adaptive optics scanning laser ophthalmoscopy (AOSLO). Methods: This was a cross-sectional pilot study with two groups: a glaucoma group with patients with moderate or severe glaucoma as per the Hodapp–Parrish–Anderson classification system and a control group with healthy individuals. The optic nerve damage in moderate glaucoma was predominantly located in only one hemisphere; the other hemisphere was un- or minimally affected on optical coherence tomography and automated perimetry and is referred to as early glaucoma. The structure of RNFL bundles and gain (%) in RNFL images with mean pixel values between 15 and 35 were analyzed. Imaging was performed one degree away from the optic disc margin at two and four cardinal clock positions in the glaucoma and control groups, respectively. The field of view was 1.3° at 2.3 μ resolution. We studied one eye per participant. Results: There were 11 glaucoma patients and 7 healthy controls. Imaging was successful at 88% of the locations in controls and early glaucoma; the reflectivity differed significantly (0.51 and 0.56, respectively, P < 0.001) but not the structure of RNFL bundles (Cohen's Kappa 0.11) between them. In patients with moderate and severe glaucoma, imaging was successful only at 46% of the locations; RNFL bundles were not discernible, and RNFL reflectivity did not differ from those with early glaucoma (P < 0.11). Conclusion: The recorded gain (%) of RNFL images obtained using AOSLO could be an objective indicator of early glaucoma. |
| first_indexed | 2024-12-10T21:26:17Z |
| format | Article |
| id | doaj.art-f0be8915b28b4c8c9dc42676dce993fa |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-10T21:26:17Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-f0be8915b28b4c8c9dc42676dce993fa2022-12-22T01:32:58ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-017082877288210.4103/ijo.IJO_1044_21Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucomaNikhil S ChoudhariSanjay KumarAshutosh RichhariyaRashmi KrishnamurthyRuchi PriyaChandra Sekhar GarudadriPurpose: To compare image characteristics of retinal nerve fiber layer (RNFL) between glaucoma patients and healthy controls using adaptive optics scanning laser ophthalmoscopy (AOSLO). Methods: This was a cross-sectional pilot study with two groups: a glaucoma group with patients with moderate or severe glaucoma as per the Hodapp–Parrish–Anderson classification system and a control group with healthy individuals. The optic nerve damage in moderate glaucoma was predominantly located in only one hemisphere; the other hemisphere was un- or minimally affected on optical coherence tomography and automated perimetry and is referred to as early glaucoma. The structure of RNFL bundles and gain (%) in RNFL images with mean pixel values between 15 and 35 were analyzed. Imaging was performed one degree away from the optic disc margin at two and four cardinal clock positions in the glaucoma and control groups, respectively. The field of view was 1.3° at 2.3 μ resolution. We studied one eye per participant. Results: There were 11 glaucoma patients and 7 healthy controls. Imaging was successful at 88% of the locations in controls and early glaucoma; the reflectivity differed significantly (0.51 and 0.56, respectively, P < 0.001) but not the structure of RNFL bundles (Cohen's Kappa 0.11) between them. In patients with moderate and severe glaucoma, imaging was successful only at 46% of the locations; RNFL bundles were not discernible, and RNFL reflectivity did not differ from those with early glaucoma (P < 0.11). Conclusion: The recorded gain (%) of RNFL images obtained using AOSLO could be an objective indicator of early glaucoma.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=8;spage=2877;epage=2882;aulast=Choudhariadaptive optics scanning laser ophthalmoscopy (aoslo) in glaucomaearly detection of glaucomareflectivity of retinal nerve fiber layer |
| spellingShingle | Nikhil S Choudhari Sanjay Kumar Ashutosh Richhariya Rashmi Krishnamurthy Ruchi Priya Chandra Sekhar Garudadri Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma Indian Journal of Ophthalmology adaptive optics scanning laser ophthalmoscopy (aoslo) in glaucoma early detection of glaucoma reflectivity of retinal nerve fiber layer |
| title | Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma |
| title_full | Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma |
| title_fullStr | Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma |
| title_full_unstemmed | Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma |
| title_short | Adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma |
| title_sort | adaptive optics scanning laser ophthalmoscopy may support early diagnosis of glaucoma |
| topic | adaptive optics scanning laser ophthalmoscopy (aoslo) in glaucoma early detection of glaucoma reflectivity of retinal nerve fiber layer |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=8;spage=2877;epage=2882;aulast=Choudhari |
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