Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study
ObjectiveThe purpose of the study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and erectile dysfunction (ED) in adult American males using a large database.MethodsWe adopted a series of statistical analyses of the relationship between NLR indices and ED prevalence...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1192113/full |
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| author | Xingliang Feng Xingliang Feng Yangyang Mei Xiaogang Wang Xiaogang Wang Li Cui Li Cui Renfang Xu Renfang Xu |
| author_facet | Xingliang Feng Xingliang Feng Yangyang Mei Xiaogang Wang Xiaogang Wang Li Cui Li Cui Renfang Xu Renfang Xu |
| author_sort | Xingliang Feng |
| collection | DOAJ |
| description | ObjectiveThe purpose of the study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and erectile dysfunction (ED) in adult American males using a large database.MethodsWe adopted a series of statistical analyses of the relationship between NLR indices and ED prevalence among participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) database using the R software.ResultsThe study included a total of 3012 participants, of whom 570 (18.9%) presented with ED. NLR levels were 2.13 (95% CI: 2.08,2.17) in those without ED and 2.36 (95% CI: 2.27,2.45) in those with ED. After adjusting for confounding variables, NLR levels were higher in patients with ED, (β, 1.21, 95% CI, 1.09-1.34, P < 0.001). In addition, a U-shaped relationship between NLR and ED was observed after controlling for all confounders. A more significant correlation (β, 1.35, 95% CI, 1.19 to 1.53, P < 0.001) existed to the right of the inflection point (1.52).ConclusionThe results of the large cross-sectional study showed a statistically significant association between the occurrence of ED and NLR, a simple, inexpensive, and readily available parameter of inflammation, in US adults. Further studies are still needed in the future to validate and replicate our findings and to investigate the specific mechanisms involved. |
| first_indexed | 2024-03-13T03:39:00Z |
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| id | doaj.art-f0bf8b01364a41acbf94b8818c38931b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T03:39:00Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-f0bf8b01364a41acbf94b8818c38931b2023-06-23T12:20:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11921131192113Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional studyXingliang Feng0Xingliang Feng1Yangyang Mei2Xiaogang Wang3Xiaogang Wang4Li Cui5Li Cui6Renfang Xu7Renfang Xu8Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, Jiangyin People’s Hospital of Jiangsu Province, Jiangyin, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Urology, First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaObjectiveThe purpose of the study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and erectile dysfunction (ED) in adult American males using a large database.MethodsWe adopted a series of statistical analyses of the relationship between NLR indices and ED prevalence among participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) database using the R software.ResultsThe study included a total of 3012 participants, of whom 570 (18.9%) presented with ED. NLR levels were 2.13 (95% CI: 2.08,2.17) in those without ED and 2.36 (95% CI: 2.27,2.45) in those with ED. After adjusting for confounding variables, NLR levels were higher in patients with ED, (β, 1.21, 95% CI, 1.09-1.34, P < 0.001). In addition, a U-shaped relationship between NLR and ED was observed after controlling for all confounders. A more significant correlation (β, 1.35, 95% CI, 1.19 to 1.53, P < 0.001) existed to the right of the inflection point (1.52).ConclusionThe results of the large cross-sectional study showed a statistically significant association between the occurrence of ED and NLR, a simple, inexpensive, and readily available parameter of inflammation, in US adults. Further studies are still needed in the future to validate and replicate our findings and to investigate the specific mechanisms involved.https://www.frontiersin.org/articles/10.3389/fendo.2023.1192113/fullneutrophil to lymphocyte ratioNHANESerectile dysfunctioncross-sectional studyinflammation |
| spellingShingle | Xingliang Feng Xingliang Feng Yangyang Mei Xiaogang Wang Xiaogang Wang Li Cui Li Cui Renfang Xu Renfang Xu Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study Frontiers in Endocrinology neutrophil to lymphocyte ratio NHANES erectile dysfunction cross-sectional study inflammation |
| title | Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study |
| title_full | Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study |
| title_fullStr | Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study |
| title_full_unstemmed | Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study |
| title_short | Association between neutrophil to lymphocyte ratio and erectile dysfunction among US males: a population-based cross-sectional study |
| title_sort | association between neutrophil to lymphocyte ratio and erectile dysfunction among us males a population based cross sectional study |
| topic | neutrophil to lymphocyte ratio NHANES erectile dysfunction cross-sectional study inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1192113/full |
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