Ishophloroglucin A Ameliorates VEGF-Induced Epithelial-Mesenchymal Transition via VEGFR2 Pathway Inhibition in Microgravity-Stimulated Human Retinal Pigment Epithelial Cells

Ishophloroglucin A Ameliorates VEGF-Induced Epithelial-Mesenchymal Transition via VEGFR2 Pathway Inhibition in Microgravity-Stimulated Human Retinal Pigment Epithelial Cells

Microgravity stimulation is associated with retinal pigment epithelial (RPE) cells that transition to mesenchymal cells (EMT), and these pathological changes cause visual impairment. Vascular endothelial growth factor (VEGF) is produced from the RPE and contributes to photoreceptor survival. However...

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Bibliographic Details
Main Authors: Myeongjoo Son, Bomi Ryu, Jun-Geon Je, You-Jin Jeon, Dae Yu Kim
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Antioxidants
Subjects:
retinal pigment epithelium
epithelial-mesenchymal transition
microgravity
Ishige okamurae
ishophloroglucin A
vascular endothelial growth factor
Online Access:https://www.mdpi.com/2076-3921/11/11/2212

Internet

https://www.mdpi.com/2076-3921/11/11/2212

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