Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18
<i>Penicillium setosum</i> represents a <i>Penicillium</i> species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of <i>P. setosum</i> CMLD18,...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/23 |
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| author | Ana Calheiros de Carvalho Cauê Santos Lima Heron Fernandes Vieira Torquato André Tarsis Domiciano Sebastião da Cruz Silva Lucas Magalhães de Abreu Miriam Uemi Edgar Julian Paredes-Gamero Paulo Cezar Vieira Thiago André Moura Veiga Lívia Soman de Medeiros |
| author_facet | Ana Calheiros de Carvalho Cauê Santos Lima Heron Fernandes Vieira Torquato André Tarsis Domiciano Sebastião da Cruz Silva Lucas Magalhães de Abreu Miriam Uemi Edgar Julian Paredes-Gamero Paulo Cezar Vieira Thiago André Moura Veiga Lívia Soman de Medeiros |
| author_sort | Ana Calheiros de Carvalho |
| collection | DOAJ |
| description | <i>Penicillium setosum</i> represents a <i>Penicillium</i> species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of <i>P. setosum</i> CMLD18, a strain isolated from <i>Swinglea glutinosa</i> (Rutaceae). HRMS-MS guided dereplication strategies and anti-leukemia assays conducted the isolation and characterization of six compounds after several chromatographic procedures: 2-chloroemodic acid (<b>2</b>), 2-chloro-1,3,8-trihydroxy-6- (hydroxymethyl)-anthraquinone (<b>7</b>), 7-chloroemodin (<b>8</b>), bisdethiobis(methylthio)acetylaranotine (<b>9</b>), fellutanine C (<b>10</b>), and 4-methyl-5,6-diihydro-2H-pyran-2-one (<b>15</b>). From the assayed metabolites, (<b>10</b>) induced cellular death against Kasumi-1, a human leukemia cell line, as well as good selectivity for it, displaying promising cytotoxic activity. Here, the correct NMR signal assignments for (<b>9</b>) are also described. Therefore, this work highlights more detailed knowledge about the <i>P. setosum</i> chemical profile as well as its biological potential, offering prospects for obtaining natural products with anti-leukemia capabilities. |
| first_indexed | 2024-03-09T11:44:00Z |
| format | Article |
| id | doaj.art-f0c070b74cb14d2fa967a61c21604444 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:44:00Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-f0c070b74cb14d2fa967a61c216044442023-11-30T23:27:46ZengMDPI AGMetabolites2218-19892022-12-011312310.3390/metabo13010023Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18Ana Calheiros de Carvalho0Cauê Santos Lima1Heron Fernandes Vieira Torquato2André Tarsis Domiciano3Sebastião da Cruz Silva4Lucas Magalhães de Abreu5Miriam Uemi6Edgar Julian Paredes-Gamero7Paulo Cezar Vieira8Thiago André Moura Veiga9Lívia Soman de Medeiros10Programa de Pós-Graduação em Biologia Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema 09972-270, BrazilDepartamento de Bioquímica, Universidade Federal de São Paulo, São Paulo 04044-020, BrazilFaculdade de Farmácia, Centro Universitário Braz Cubas, Mogi das Cruzes 08773-380, BrazilDepartamento de Bioquímica, Universidade Federal de São Paulo, São Paulo 04044-020, BrazilInstituto de Ciências Exatas, Universidade Federal do Sul e Sudeste do Pará, Marabá 68505-080, BrazilDepartamento de Fitopatologia, Universidade Federal de Viçosa, Viçosa 36570-900, BrazilDepartamento de Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema 09972-270, BrazilFaculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, BrazilNPPNS, Department of BioMolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto 14040-903, BrazilDepartamento de Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema 09972-270, BrazilDepartamento de Química, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Diadema 09972-270, Brazil<i>Penicillium setosum</i> represents a <i>Penicillium</i> species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of <i>P. setosum</i> CMLD18, a strain isolated from <i>Swinglea glutinosa</i> (Rutaceae). HRMS-MS guided dereplication strategies and anti-leukemia assays conducted the isolation and characterization of six compounds after several chromatographic procedures: 2-chloroemodic acid (<b>2</b>), 2-chloro-1,3,8-trihydroxy-6- (hydroxymethyl)-anthraquinone (<b>7</b>), 7-chloroemodin (<b>8</b>), bisdethiobis(methylthio)acetylaranotine (<b>9</b>), fellutanine C (<b>10</b>), and 4-methyl-5,6-diihydro-2H-pyran-2-one (<b>15</b>). From the assayed metabolites, (<b>10</b>) induced cellular death against Kasumi-1, a human leukemia cell line, as well as good selectivity for it, displaying promising cytotoxic activity. Here, the correct NMR signal assignments for (<b>9</b>) are also described. Therefore, this work highlights more detailed knowledge about the <i>P. setosum</i> chemical profile as well as its biological potential, offering prospects for obtaining natural products with anti-leukemia capabilities.https://www.mdpi.com/2218-1989/13/1/23<i>Penicillium setosum</i><i>Swinglea glutinosa</i>dereplicationleukemia |
| spellingShingle | Ana Calheiros de Carvalho Cauê Santos Lima Heron Fernandes Vieira Torquato André Tarsis Domiciano Sebastião da Cruz Silva Lucas Magalhães de Abreu Miriam Uemi Edgar Julian Paredes-Gamero Paulo Cezar Vieira Thiago André Moura Veiga Lívia Soman de Medeiros Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18 Metabolites <i>Penicillium setosum</i> <i>Swinglea glutinosa</i> dereplication leukemia |
| title | Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18 |
| title_full | Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18 |
| title_fullStr | Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18 |
| title_full_unstemmed | Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18 |
| title_short | Chemodiversity and Anti-Leukemia Effect of Metabolites from <i>Penicillium setosum</i> CMLD 18 |
| title_sort | chemodiversity and anti leukemia effect of metabolites from i penicillium setosum i cmld 18 |
| topic | <i>Penicillium setosum</i> <i>Swinglea glutinosa</i> dereplication leukemia |
| url | https://www.mdpi.com/2218-1989/13/1/23 |
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