Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone
In exploring the difference in the wettability of fibers with various structures, three inner constructions of fibers, namely, uniaxial, Janus and chimeric Janus, have been fabricated by electrospinning. In electrospun fibers, polyvinyl pyrrolidone and cellulose acetate were used as a polymer matrix...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523000679 |
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| author | Menglong Wang Ruiliang Ge Ping Zhao Gareth R. Williams Deng-Guang Yu S.W. Annie Bligh |
| author_facet | Menglong Wang Ruiliang Ge Ping Zhao Gareth R. Williams Deng-Guang Yu S.W. Annie Bligh |
| author_sort | Menglong Wang |
| collection | DOAJ |
| description | In exploring the difference in the wettability of fibers with various structures, three inner constructions of fibers, namely, uniaxial, Janus and chimeric Janus, have been fabricated by electrospinning. In electrospun fibers, polyvinyl pyrrolidone and cellulose acetate were used as a polymer matrix and ketoprofen was used as a model drug. Morphologies and inner structures were respectively investigated by scanning electron microscopy (SEM) and Transmission electron microscopy (TEM). Physical states and compatibilities of materials were detected by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Water contact angle (WCA) tests were conducted to determine the difference between wettability and wetting time among assorted fiber membranes. Results showed that the wettability gradient could drive water movement and wetting, which resulted in the rapid decrease of the WCA, to prepare Janus and chimeric Janus fiber membranes compared with uniaxial fiber membranes. Otherwise, in vitro drug release experiments were carried out and four fitting models were applied in matching release profiles. The results showed that electrospun fiber membranes belonged to sustained-release systems and such membranes were influenced by drug diffusion and backbone corrosion effects. In this study, whether electrospun multilayer Janus fibers could affect wettability and drug release was investigated. |
| first_indexed | 2024-04-10T05:25:20Z |
| format | Article |
| id | doaj.art-f0c08ead22ba4eb0beec18f1b7044dc6 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T05:25:20Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-f0c08ead22ba4eb0beec18f1b7044dc62023-03-08T04:13:43ZengElsevierMaterials & Design0264-12752023-02-01226111652Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidoneMenglong Wang0Ruiliang Ge1Ping Zhao2Gareth R. Williams3Deng-Guang Yu4S.W. Annie Bligh5School of Health Sciences, Caritas Institute of Higher Education, Hong Kong, China; School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Outpatient, Third Affiliated Hospital of Navy Military Medical University, Shanghai 200438, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaUCL School of Pharmacy, University College London, London WC1E 6BT, UKSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China; Corresponding authors.School of Health Sciences, Caritas Institute of Higher Education, Hong Kong, China; Corresponding authors.In exploring the difference in the wettability of fibers with various structures, three inner constructions of fibers, namely, uniaxial, Janus and chimeric Janus, have been fabricated by electrospinning. In electrospun fibers, polyvinyl pyrrolidone and cellulose acetate were used as a polymer matrix and ketoprofen was used as a model drug. Morphologies and inner structures were respectively investigated by scanning electron microscopy (SEM) and Transmission electron microscopy (TEM). Physical states and compatibilities of materials were detected by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Water contact angle (WCA) tests were conducted to determine the difference between wettability and wetting time among assorted fiber membranes. Results showed that the wettability gradient could drive water movement and wetting, which resulted in the rapid decrease of the WCA, to prepare Janus and chimeric Janus fiber membranes compared with uniaxial fiber membranes. Otherwise, in vitro drug release experiments were carried out and four fitting models were applied in matching release profiles. The results showed that electrospun fiber membranes belonged to sustained-release systems and such membranes were influenced by drug diffusion and backbone corrosion effects. In this study, whether electrospun multilayer Janus fibers could affect wettability and drug release was investigated.http://www.sciencedirect.com/science/article/pii/S0264127523000679Tri-fluid electrospinningChimeric Janus microfiberWettabilityDrug releaseHydrophobic difference |
| spellingShingle | Menglong Wang Ruiliang Ge Ping Zhao Gareth R. Williams Deng-Guang Yu S.W. Annie Bligh Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone Materials & Design Tri-fluid electrospinning Chimeric Janus microfiber Wettability Drug release Hydrophobic difference |
| title | Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone |
| title_full | Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone |
| title_fullStr | Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone |
| title_full_unstemmed | Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone |
| title_short | Exploring wettability difference-driven wetting by utilizing electrospun chimeric Janus microfiber comprising cellulose acetate and polyvinylpyrrolidone |
| title_sort | exploring wettability difference driven wetting by utilizing electrospun chimeric janus microfiber comprising cellulose acetate and polyvinylpyrrolidone |
| topic | Tri-fluid electrospinning Chimeric Janus microfiber Wettability Drug release Hydrophobic difference |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523000679 |
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