Synthesis and Spectroscopic Characterization of a New Series of Tetrazole Compounds
The current study involves synthesis and characterization of a new family of tetrazole derivatives. The synthetic pathway includes two steps, as described here: Initial step was synthesis of N-(4-(6-methylbenzothiazol-2-yl) phenyl)-1-(substituted phenyl)methanimine (1-7), via the reaction of 4-(6-m...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Salahaddin University-Erbil
2022-12-01
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| Series: | Zanco Journal of Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/359 |
| Summary: | The current study involves synthesis and characterization of a new family of tetrazole derivatives. The synthetic pathway includes two steps, as described here: Initial step was synthesis of N-(4-(6-methylbenzothiazol-2-yl) phenyl)-1-(substituted phenyl)methanimine (1-7), via the reaction of 4-(6-methylbenzothiazol-2-yl)aniline with a variety of substituted benzaldehydes in absolute ethanol utilizing glacial acetic acid as catalyst. The next step was synthesis of tetrazole derivatives (8-14) by the reaction of the synthesized imines (1-7) with sodium azide in dry dioxane. Spectroscopic methods (FT-IR, 1H-NMR and 13C-NMR) were used to determine the structures of the produced products. The synthesized compounds were tested for antibacterial activity against two types of bacteria Staphylococcus aureus (Gram +ve) and Escherichia coli (Gram -ve). The results showed good activities against both types of bacteria.
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| ISSN: | 2218-0230 2412-3986 |