Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review
(1) Background: The widespread development of resistance among <i>Neisseria gonorrhoeae</i> (NG) clinical isolates has been reported by surveillance systems around the world. This meta-analysis estimated the changes in susceptibility patterns among antibiotics under surveillance in Austr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/8/4/191 |
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| author | Stephanie Fletcher-Lartey Mithilesh Dronavalli Kate Alexander Sayontonee Ghosh Leng Boonwaat Jane Thomas Amanda Robinson Zeel Patel Bradley Forssman Naru Pal |
| author_facet | Stephanie Fletcher-Lartey Mithilesh Dronavalli Kate Alexander Sayontonee Ghosh Leng Boonwaat Jane Thomas Amanda Robinson Zeel Patel Bradley Forssman Naru Pal |
| author_sort | Stephanie Fletcher-Lartey |
| collection | DOAJ |
| description | (1) Background: The widespread development of resistance among <i>Neisseria gonorrhoeae</i> (NG) clinical isolates has been reported by surveillance systems around the world. This meta-analysis estimated the changes in susceptibility patterns among antibiotics under surveillance in Australia and New Zealand. (2) Methods: Articles published in English from 1980−2018, from Australia or New Zealand, that met the selection criteria were included. The meta-analysis was carried out using the R statistical software. (3) Results: In Australia, there has been decreasing susceptibility of gonococcal isolates to selected antimicrobials over time. Azithromycin (Odds Ratio (OR): 0.73; 95% Confidence Interval (CI) 0.64−0.82) and ceftriaxone (OR: 0.69; 95% CI 0.59−0.80) showed decreasing levels of susceptibility each year. Western Australia (OR: 0.76; 95% CI 0.60−0.96) and Victoria (OR: 0.74; 95% CI 0.60−0.90) also had decreasing levels of susceptibility to ceftriaxone over time compared with other states and territories. (4) Conclusions: The results highlight the need for the development of new approaches for managing cases of gonorrhoea. Improved antimicrobial stewardship, enhanced surveillance and contact tracing are needed to identify and respond to changes in antibiotic resistance in a timely manner. Increasing awareness and public health follow-up of cases can help to interrupt the cycle of infection and limit transmission. |
| first_indexed | 2024-12-20T08:20:28Z |
| format | Article |
| id | doaj.art-f0c1f6f301054602866a133fa75541e1 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-20T08:20:28Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-f0c1f6f301054602866a133fa75541e12022-12-21T19:47:03ZengMDPI AGAntibiotics2079-63822019-10-018419110.3390/antibiotics8040191antibiotics8040191Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic ReviewStephanie Fletcher-Lartey0Mithilesh Dronavalli1Kate Alexander2Sayontonee Ghosh3Leng Boonwaat4Jane Thomas5Amanda Robinson6Zeel Patel7Bradley Forssman8Naru Pal9Public Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, AustraliaPublic Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, AustraliaPublic Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, AustraliaPublic Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, AustraliaPublic Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, AustraliaPublic Health Unit, Nepean Blue Mountains Local Health District, Penrith, NSW 2750, AustraliaPublic Health Unit, Nepean Blue Mountains Local Health District, Penrith, NSW 2750, AustraliaPublic Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, AustraliaPublic Health Unit, Nepean Blue Mountains Local Health District, Penrith, NSW 2750, AustraliaPublic Health Unit, South Western Sydney Local Health District, Liverpool, NSW 2170, Australia(1) Background: The widespread development of resistance among <i>Neisseria gonorrhoeae</i> (NG) clinical isolates has been reported by surveillance systems around the world. This meta-analysis estimated the changes in susceptibility patterns among antibiotics under surveillance in Australia and New Zealand. (2) Methods: Articles published in English from 1980−2018, from Australia or New Zealand, that met the selection criteria were included. The meta-analysis was carried out using the R statistical software. (3) Results: In Australia, there has been decreasing susceptibility of gonococcal isolates to selected antimicrobials over time. Azithromycin (Odds Ratio (OR): 0.73; 95% Confidence Interval (CI) 0.64−0.82) and ceftriaxone (OR: 0.69; 95% CI 0.59−0.80) showed decreasing levels of susceptibility each year. Western Australia (OR: 0.76; 95% CI 0.60−0.96) and Victoria (OR: 0.74; 95% CI 0.60−0.90) also had decreasing levels of susceptibility to ceftriaxone over time compared with other states and territories. (4) Conclusions: The results highlight the need for the development of new approaches for managing cases of gonorrhoea. Improved antimicrobial stewardship, enhanced surveillance and contact tracing are needed to identify and respond to changes in antibiotic resistance in a timely manner. Increasing awareness and public health follow-up of cases can help to interrupt the cycle of infection and limit transmission.https://www.mdpi.com/2079-6382/8/4/191<i>neisseria gonorrhoeae</i>sexually transmitted infectionssurveillanceantibiotic resistanceantimicrobial testingaustralianew zealand |
| spellingShingle | Stephanie Fletcher-Lartey Mithilesh Dronavalli Kate Alexander Sayontonee Ghosh Leng Boonwaat Jane Thomas Amanda Robinson Zeel Patel Bradley Forssman Naru Pal Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review Antibiotics <i>neisseria gonorrhoeae</i> sexually transmitted infections surveillance antibiotic resistance antimicrobial testing australia new zealand |
| title | Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review |
| title_full | Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review |
| title_fullStr | Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review |
| title_full_unstemmed | Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review |
| title_short | Trends in Antimicrobial Resistance Patterns in Neisseria Gonorrhoeae in Australia and New Zealand: A Meta-analysis and Systematic Review |
| title_sort | trends in antimicrobial resistance patterns in neisseria gonorrhoeae in australia and new zealand a meta analysis and systematic review |
| topic | <i>neisseria gonorrhoeae</i> sexually transmitted infections surveillance antibiotic resistance antimicrobial testing australia new zealand |
| url | https://www.mdpi.com/2079-6382/8/4/191 |
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