Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study
Abstract Background Nephrotic syndrome (NS) is characterized by dyslipidemia which is a well-known risk factor for atherogenesis. Atherosclerosis in childhood is mostly subclinical and endothelial dysfunction is known to precede this. Evidence for screening for endothelial dysfunction and cardiovasc...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-018-0878-5 |
| _version_ | 1819113327176974336 |
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| author | S. K. Patnaik P. Kumar M. Bamal S. Patel M. P. Yadav V. Kumar A. Sinha A. Bagga M. Kanitkar |
| author_facet | S. K. Patnaik P. Kumar M. Bamal S. Patel M. P. Yadav V. Kumar A. Sinha A. Bagga M. Kanitkar |
| author_sort | S. K. Patnaik |
| collection | DOAJ |
| description | Abstract Background Nephrotic syndrome (NS) is characterized by dyslipidemia which is a well-known risk factor for atherogenesis. Atherosclerosis in childhood is mostly subclinical and endothelial dysfunction is known to precede this. Evidence for screening for endothelial dysfunction and cardiovascular risk factors and early identification of premature onset of atherosclerosis in childhood NS remains tenuous in the absence of well-designed prospective studies addressing cardiovascular comorbidity in NS. The objective of our study is to examine endothelial dysfunction and short-term cardiovascular outcomes in a carefully phenotyped cohort of patients with Nephrotic syndrome as compared to healthy controls. Methods In a multi-centric prospective cohort study, 70 Steroid Resistant NS (SRNS), 70 Steroid Sensitive (SSNS) patients along with 70 Healthy Controls are being recruited. After a baseline assessment of functional and structural status of heart (2D Echocardiography), arteries (Carotid Doppler and Intima Media Thickness measurements) and microcirculation [a combination of 2D Echocardiography, Laser Doppler Flowmetry (LDF) and Brachial Artery Flow mediated dilation (FMD) and Nail Fold Capillaroscopy (NFC)], the patients are being investigated for endothelial dysfunction. Venous blood sample (15 ml) is being collected for routine investigations and assay of biochemical endothelial markers through Flow Cytometry. The patients will be followed up at 12 months and 24 months after the recruitment to look for any change from baseline period. Discussion This study will able to provide a better understanding of the epidemiology of endothelial dysfunction and associated subclinical cardiovascular co-morbidity in childhood NS. Findings on characterization of prevalence of endothelial dysfunction and subclinical markers may be used to design future randomized controlled trials for evaluating the efficacy of preventive and therapeutic interventions in reducing the incidence of cardiovascular disease. |
| first_indexed | 2024-12-22T04:27:38Z |
| format | Article |
| id | doaj.art-f0c21d8f8f7b42619e331d276d525d70 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-22T04:27:38Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f0c21d8f8f7b42619e331d276d525d702022-12-21T18:39:08ZengBMCBMC Nephrology1471-23692018-04-0119111010.1186/s12882-018-0878-5Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort studyS. K. Patnaik0P. Kumar1M. Bamal2S. Patel3M. P. Yadav4V. Kumar5A. Sinha6A. Bagga7M. Kanitkar8Department of Pediatrics, Army Hospital Research and ReferralDepartment of Pediatrics, Army Hospital Research and ReferralDepartment of Pediatrics, Army Hospital Research and ReferralDepartment of Pediatrics, Army Hospital Research and ReferralDepartment of Pediatrics, Army Hospital Research and ReferralDepartment of Pediatrics, Army Hospital Research and ReferralDivision of Pediatric Nephrology and ICMR Center for Advanced Research In Nephrology, Department of Pediatrics, All India Institute of Medical SciencesDivision of Pediatric Nephrology and ICMR Center for Advanced Research In Nephrology, Department of Pediatrics, All India Institute of Medical SciencesArmed Forced Medical CollegeAbstract Background Nephrotic syndrome (NS) is characterized by dyslipidemia which is a well-known risk factor for atherogenesis. Atherosclerosis in childhood is mostly subclinical and endothelial dysfunction is known to precede this. Evidence for screening for endothelial dysfunction and cardiovascular risk factors and early identification of premature onset of atherosclerosis in childhood NS remains tenuous in the absence of well-designed prospective studies addressing cardiovascular comorbidity in NS. The objective of our study is to examine endothelial dysfunction and short-term cardiovascular outcomes in a carefully phenotyped cohort of patients with Nephrotic syndrome as compared to healthy controls. Methods In a multi-centric prospective cohort study, 70 Steroid Resistant NS (SRNS), 70 Steroid Sensitive (SSNS) patients along with 70 Healthy Controls are being recruited. After a baseline assessment of functional and structural status of heart (2D Echocardiography), arteries (Carotid Doppler and Intima Media Thickness measurements) and microcirculation [a combination of 2D Echocardiography, Laser Doppler Flowmetry (LDF) and Brachial Artery Flow mediated dilation (FMD) and Nail Fold Capillaroscopy (NFC)], the patients are being investigated for endothelial dysfunction. Venous blood sample (15 ml) is being collected for routine investigations and assay of biochemical endothelial markers through Flow Cytometry. The patients will be followed up at 12 months and 24 months after the recruitment to look for any change from baseline period. Discussion This study will able to provide a better understanding of the epidemiology of endothelial dysfunction and associated subclinical cardiovascular co-morbidity in childhood NS. Findings on characterization of prevalence of endothelial dysfunction and subclinical markers may be used to design future randomized controlled trials for evaluating the efficacy of preventive and therapeutic interventions in reducing the incidence of cardiovascular disease.http://link.springer.com/article/10.1186/s12882-018-0878-5Nephrotic syndromePredictionOutcomeEndothelial dysfunctionLaser Doppler FlowmetryCardiovascular disease |
| spellingShingle | S. K. Patnaik P. Kumar M. Bamal S. Patel M. P. Yadav V. Kumar A. Sinha A. Bagga M. Kanitkar Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study BMC Nephrology Nephrotic syndrome Prediction Outcome Endothelial dysfunction Laser Doppler Flowmetry Cardiovascular disease |
| title | Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study |
| title_full | Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study |
| title_fullStr | Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study |
| title_full_unstemmed | Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study |
| title_short | Cardiovascular outcomes of Nephrotic syndrome in childhood (CVONS) study: a protocol for prospective cohort study |
| title_sort | cardiovascular outcomes of nephrotic syndrome in childhood cvons study a protocol for prospective cohort study |
| topic | Nephrotic syndrome Prediction Outcome Endothelial dysfunction Laser Doppler Flowmetry Cardiovascular disease |
| url | http://link.springer.com/article/10.1186/s12882-018-0878-5 |
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