Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements
Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold na...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/3/664 |
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| author | Atieh Jahangiri-Manesh Marziyeh Mousazadeh Shirinsadat Taji Abbas Bahmani Atefeh Zarepour Ali Zarrabi Esmaeel Sharifi Mostafa Azimzadeh |
| author_facet | Atieh Jahangiri-Manesh Marziyeh Mousazadeh Shirinsadat Taji Abbas Bahmani Atefeh Zarepour Ali Zarrabi Esmaeel Sharifi Mostafa Azimzadeh |
| author_sort | Atieh Jahangiri-Manesh |
| collection | DOAJ |
| description | Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both NIR-responsive cargo delivery and photothermal/photodynamic therapies. In this review, a comprehensive insight into the properties, synthesis methods and toxicity of gold nanorods are overviewed first. For the main body of the review, the therapeutic applications of GNRs are provided in four main sections: (i) drug delivery, (ii) gene delivery, (iii) photothermal/photodynamic therapy, and (iv) theranostics applications. Finally, the challenges and future perspectives of their therapeutic application are discussed. |
| first_indexed | 2024-03-09T12:58:22Z |
| format | Article |
| id | doaj.art-f0c2b2490b6b45bc8579bbce45603273 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:58:22Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f0c2b2490b6b45bc8579bbce456032732023-11-30T21:58:09ZengMDPI AGPharmaceutics1999-49232022-03-0114366410.3390/pharmaceutics14030664Gold Nanorods for Drug and Gene Delivery: An Overview of Recent AdvancementsAtieh Jahangiri-Manesh0Marziyeh Mousazadeh1Shirinsadat Taji2Abbas Bahmani3Atefeh Zarepour4Ali Zarrabi5Esmaeel Sharifi6Mostafa Azimzadeh7Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran P.O. Box 14115-154, IranDepartment of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran P.O. Box 14115-154, IranDepartment of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran P.O. Box 14115-154, IranInstitute for Nanoscience & Nanotechnology (INST), Sharif University of Technology, Tehran P.O. Box 14588-89694, IranDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul 34396, TurkeyDepartment of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul 34396, TurkeyDepartment of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan P.O. Box 65178-38736, IranMedical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd P.O. Box 887-89165, IranOver the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to their several advantageous. However, rod-shaped gold nanoparticles, or gold nanorods (GNRs), have some more unique physical, optical, and chemical properties, making them proper candidates for biomedical applications including drug/gene delivery, photothermal/photodynamic therapy, and theranostics. Most of their therapeutic applications are based on their ability for tunable heat generation upon exposure to near-infrared (NIR) radiation, which is helpful in both NIR-responsive cargo delivery and photothermal/photodynamic therapies. In this review, a comprehensive insight into the properties, synthesis methods and toxicity of gold nanorods are overviewed first. For the main body of the review, the therapeutic applications of GNRs are provided in four main sections: (i) drug delivery, (ii) gene delivery, (iii) photothermal/photodynamic therapy, and (iv) theranostics applications. Finally, the challenges and future perspectives of their therapeutic application are discussed.https://www.mdpi.com/1999-4923/14/3/664gold nanorodsdrug deliverygene therapyphotothermal therapyphotodynamic therapytheranostics |
| spellingShingle | Atieh Jahangiri-Manesh Marziyeh Mousazadeh Shirinsadat Taji Abbas Bahmani Atefeh Zarepour Ali Zarrabi Esmaeel Sharifi Mostafa Azimzadeh Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements Pharmaceutics gold nanorods drug delivery gene therapy photothermal therapy photodynamic therapy theranostics |
| title | Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements |
| title_full | Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements |
| title_fullStr | Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements |
| title_full_unstemmed | Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements |
| title_short | Gold Nanorods for Drug and Gene Delivery: An Overview of Recent Advancements |
| title_sort | gold nanorods for drug and gene delivery an overview of recent advancements |
| topic | gold nanorods drug delivery gene therapy photothermal therapy photodynamic therapy theranostics |
| url | https://www.mdpi.com/1999-4923/14/3/664 |
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