Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study
(1) Background: Immunoglobulin gamma subclass 4 (IgG4) is a serum protein belonging to the immunoglobulin superfamily. It has a central role in certain immune-mediated conditions defined as IgG4-related disease. There is a paucity of data regarding the potential association of IgG4 and cardiovascula...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/8/1168 |
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| author | Igor Volodarsky Anamaria Anton Liaz Zilberman Irina Fugenfirov Eran Neumark Stephen Malnick Yair Levy Jacob George Sorel Goland |
| author_facet | Igor Volodarsky Anamaria Anton Liaz Zilberman Irina Fugenfirov Eran Neumark Stephen Malnick Yair Levy Jacob George Sorel Goland |
| author_sort | Igor Volodarsky |
| collection | DOAJ |
| description | (1) Background: Immunoglobulin gamma subclass 4 (IgG4) is a serum protein belonging to the immunoglobulin superfamily. It has a central role in certain immune-mediated conditions defined as IgG4-related disease. There is a paucity of data regarding the potential association of IgG4 and cardiovascular diseases. Our aim is to study the serum levels of IgG4 in patients with ischemic and non-ischemic dilated cardiomyopathy (DCM). (2) Methods: patients with ischemic and non-ischemic DCM were included in this study. Non-ischemic DCM was defined as a left ventricular ejection fraction (LVEF) < 40% without coronary artery disease (CAD). Ischemic DCM was defined as a LVEF < 40% and proven CAD. The serum concentrations of IgG4 were measured by turbidimetry. (3) Results: Overall 98 patients with cardiomyopathy had significantly higher levels of IgG4 compared with the control group (77.4 ± 64.0 vs. 50.3 ± 28.8 mg/dL, <i>p</i> < 0.01). Although there was no difference in the total IgG levels in patients with ischemic DCM, the serum concentrations of IgG4 were significantly higher than the corresponding values in the control group (89.8 ± 67.3 vs. 50.3 ± 28.8 mg/dL; interquartile ranges: 40.4–126.5 vs. 31.8–66.8 mg/dL, <i>p</i> < 0.01). This was altered by gender and smoking. (4) Conclusions: The patients with ischemic DCM had increased serum concentrations of IgG4. Future studies are warranted to explore the potential role of an IgG4-mediated process in patients with heart failure with reduced LVEF. |
| first_indexed | 2024-03-09T10:00:57Z |
| format | Article |
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| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T10:00:57Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-f0c43af78f6c4dcbbe9171dbdab725c72023-12-01T23:26:12ZengMDPI AGBiology2079-77372022-08-01118116810.3390/biology11081168Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled StudyIgor Volodarsky0Anamaria Anton1Liaz Zilberman2Irina Fugenfirov3Eran Neumark4Stephen Malnick5Yair Levy6Jacob George7Sorel Goland8The Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, IsraelThe Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, IsraelThe Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, IsraelThe Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, IsraelDepartment of Internal Medicine E, Meir Hospital, Kfar 4428164, IsraelThe Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, IsraelDepartment of Internal Medicine E, Meir Hospital, Kfar 4428164, IsraelThe Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, IsraelThe Heart Institute, Kaplan Medical Center, Hadassah Medical School, Hebrew University, Rehovot 76100, Israel(1) Background: Immunoglobulin gamma subclass 4 (IgG4) is a serum protein belonging to the immunoglobulin superfamily. It has a central role in certain immune-mediated conditions defined as IgG4-related disease. There is a paucity of data regarding the potential association of IgG4 and cardiovascular diseases. Our aim is to study the serum levels of IgG4 in patients with ischemic and non-ischemic dilated cardiomyopathy (DCM). (2) Methods: patients with ischemic and non-ischemic DCM were included in this study. Non-ischemic DCM was defined as a left ventricular ejection fraction (LVEF) < 40% without coronary artery disease (CAD). Ischemic DCM was defined as a LVEF < 40% and proven CAD. The serum concentrations of IgG4 were measured by turbidimetry. (3) Results: Overall 98 patients with cardiomyopathy had significantly higher levels of IgG4 compared with the control group (77.4 ± 64.0 vs. 50.3 ± 28.8 mg/dL, <i>p</i> < 0.01). Although there was no difference in the total IgG levels in patients with ischemic DCM, the serum concentrations of IgG4 were significantly higher than the corresponding values in the control group (89.8 ± 67.3 vs. 50.3 ± 28.8 mg/dL; interquartile ranges: 40.4–126.5 vs. 31.8–66.8 mg/dL, <i>p</i> < 0.01). This was altered by gender and smoking. (4) Conclusions: The patients with ischemic DCM had increased serum concentrations of IgG4. Future studies are warranted to explore the potential role of an IgG4-mediated process in patients with heart failure with reduced LVEF.https://www.mdpi.com/2079-7737/11/8/1168heart failureischemic cardiomyopathyidiopathic dilated cardiomyopathyIgG4 related disease |
| spellingShingle | Igor Volodarsky Anamaria Anton Liaz Zilberman Irina Fugenfirov Eran Neumark Stephen Malnick Yair Levy Jacob George Sorel Goland Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study Biology heart failure ischemic cardiomyopathy idiopathic dilated cardiomyopathy IgG4 related disease |
| title | Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study |
| title_full | Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study |
| title_fullStr | Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study |
| title_full_unstemmed | Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study |
| title_short | Elevated Serum Levels of IgG4 in Patients with Heart Failure with Reduced Ejection Fraction: A Prospective Controlled Study |
| title_sort | elevated serum levels of igg4 in patients with heart failure with reduced ejection fraction a prospective controlled study |
| topic | heart failure ischemic cardiomyopathy idiopathic dilated cardiomyopathy IgG4 related disease |
| url | https://www.mdpi.com/2079-7737/11/8/1168 |
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