Low-Impact Ampakine CX1739 Exerts Pro-Cognitive Effects and Reverses Opiate-Induced Respiratory Depression in Rodents

Low-Impact Ampakine CX1739 Exerts Pro-Cognitive Effects and Reverses Opiate-Induced Respiratory Depression in Rodents

AMPA-glutamate receptors (AMPARs) are expressed throughout the CNS and mediate the majority of fast excitatory synaptic transmission. Ampakines are orally available small molecules that bind allosterically to AMPARs and enhance excitatory currents elicited by the endogenous agonist glutamate. In pre...

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Bibliographic Details
Main Authors: Daniel Pierce Radin, Sheng Zhong, Rok Cerne, Mohammed Shoaib, Jeffrey M. Witkin, Arnold Lippa
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Future Pharmacology
Subjects:
ADHD
ampakine
AMPA receptor
hyperactivity
LTP
opiate-induced respiratory depression
Online Access:https://www.mdpi.com/2673-9879/4/1/12

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