Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male
Background: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male.Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this st...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.813823/full |
| _version_ | 1811271935846252544 |
|---|---|
| author | Shiyang Wang Xiulin Wen Ruimin Zhao Yanxia Bai |
| author_facet | Shiyang Wang Xiulin Wen Ruimin Zhao Yanxia Bai |
| author_sort | Shiyang Wang |
| collection | DOAJ |
| description | Background: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male.Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance.Results: Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, p = 0.043; rs7248488, OR = 1.45, p = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, p = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, p = 0.025) and a log-additive model (OR = 1.44, p = 0.026).Conclusions: We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in ZNF208 create susceptibility to laryngeal cancer in the Northwestern Chinese Han male. |
| first_indexed | 2024-04-12T22:30:05Z |
| format | Article |
| id | doaj.art-f0c6df965acf4719bd36ae052fd3b1a0 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T22:30:05Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-f0c6df965acf4719bd36ae052fd3b1a02022-12-22T03:14:00ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.813823813823Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han MaleShiyang Wang0Xiulin Wen1Ruimin Zhao2Yanxia Bai3Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Nursing, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaBackground: Laryngeal cancer is more common in middle-aged and older men. We conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer (LC) risk in the Northwestern Chinese Han male.Methods: A total of 352 subjects (172 LC patients and 180 controls) were involved in this study. Agena MassARRAY was used to determine the genotypes. Unconditional logistic regression analysis was performed to explore the relevance.Results: Two SNPs were associated with the risk of LC: rs8103163, OR = 1.41, p = 0.043; rs7248488, OR = 1.45, p = 0.025. Furthermore, rs8103163 was associated with an increased risk of LC under a log-additive model (OR = 1.40, p = 0.042), and rs7248488 was related to a higher risk of LC under a recessive model (OR = 2.33, p = 0.025) and a log-additive model (OR = 1.44, p = 0.026).Conclusions: We first demonstrated that the rs8103163 A allele and the rs7248488 A allele in ZNF208 create susceptibility to laryngeal cancer in the Northwestern Chinese Han male.https://www.frontiersin.org/articles/10.3389/fgene.2022.813823/fullZNF208 genegenetic variantslaryngeal cancerNorthwestern Chinese Han malecase-control study |
| spellingShingle | Shiyang Wang Xiulin Wen Ruimin Zhao Yanxia Bai Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male Frontiers in Genetics ZNF208 gene genetic variants laryngeal cancer Northwestern Chinese Han male case-control study |
| title | Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male |
| title_full | Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male |
| title_fullStr | Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male |
| title_full_unstemmed | Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male |
| title_short | Genetic Variation in the ZNF208 Gene at rs8103163 and rs7248488 Is Associated With Laryngeal Cancer in the Northwestern Chinese Han Male |
| title_sort | genetic variation in the znf208 gene at rs8103163 and rs7248488 is associated with laryngeal cancer in the northwestern chinese han male |
| topic | ZNF208 gene genetic variants laryngeal cancer Northwestern Chinese Han male case-control study |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.813823/full |
| work_keys_str_mv | AT shiyangwang geneticvariationintheznf208geneatrs8103163andrs7248488isassociatedwithlaryngealcancerinthenorthwesternchinesehanmale AT xiulinwen geneticvariationintheznf208geneatrs8103163andrs7248488isassociatedwithlaryngealcancerinthenorthwesternchinesehanmale AT ruiminzhao geneticvariationintheznf208geneatrs8103163andrs7248488isassociatedwithlaryngealcancerinthenorthwesternchinesehanmale AT yanxiabai geneticvariationintheznf208geneatrs8103163andrs7248488isassociatedwithlaryngealcancerinthenorthwesternchinesehanmale |