NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy

NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy

Pathological growth of cardiomyocytes during hypertrophy is characterized by excess protein synthesis; however, the regulatory mechanism remains largely unknown. Using a neonatal rat ventricular myocytes (NRVMs) model, here we find that the expression of nucleosome assembly protein 1 like 5 (Nap1l5)...

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Bibliographic Details
Main Authors: Ningning Guo, Di Zheng, Jiaxin Sun, Jian Lv, Shun Wang, Yu Fang, Zhenyi Zhao, Sai Zeng, Qiuxiao Guo, Jingjing Tong, Zhihua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiomyocyte hypertrophy
NAP1L5
translation control
nucleolar hypertrophy
ribosome assembly
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.791501/full

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