Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence
The isogenic set of Yersinia pestis strains including wild-type strain 231 and its mutants with deletions of the structural genes, wabD, waaL, waaQ, waaE, and hldE, responsible for core oligosaccharide synthesis was generated using site directed mutagenesis. It was shown that gradual decrease of the...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2009-02-01
|
| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/1002 |
| _version_ | 1797221045176893440 |
|---|---|
| author | S. V. Dentovskaya M. E. Platonov T. I. Kombarova G. M. Titareva I. V. Bakhteeva R. Z. Shaikhutdinova S. A. Ivanov A. P. Anisimov |
| author_facet | S. V. Dentovskaya M. E. Platonov T. I. Kombarova G. M. Titareva I. V. Bakhteeva R. Z. Shaikhutdinova S. A. Ivanov A. P. Anisimov |
| author_sort | S. V. Dentovskaya |
| collection | DOAJ |
| description | The isogenic set of Yersinia pestis strains including wild-type strain 231 and its mutants with deletions of the structural genes, wabD, waaL, waaQ, waaE, and hldE, responsible for core oligosaccharide synthesis was generated using site directed mutagenesis. It was shown that gradual decrease of the core-oligosaccharide length was accompanied by reduction of mutants' virulence in subcutaneously infected mice and guinea pigs. |
| first_indexed | 2024-03-08T13:44:56Z |
| format | Article |
| id | doaj.art-f0c88e810f084304bc477e00013c3b28 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:59:11Z |
| publishDate | 2009-02-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-f0c88e810f084304bc477e00013c3b282024-04-05T16:47:05ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2009-02-0101(99)505110.21055/0370-1069-2009-1(99)-50-51985Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> VirulenceS. V. Dentovskaya0M. E. Platonov1T. I. Kombarova2G. M. Titareva3I. V. Bakhteeva4R. Z. Shaikhutdinova5S. A. Ivanov6A. P. Anisimov7State Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskState Research Center fo r Applied Microbiology and Biotechnology, ObolenskThe isogenic set of Yersinia pestis strains including wild-type strain 231 and its mutants with deletions of the structural genes, wabD, waaL, waaQ, waaE, and hldE, responsible for core oligosaccharide synthesis was generated using site directed mutagenesis. It was shown that gradual decrease of the core-oligosaccharide length was accompanied by reduction of mutants' virulence in subcutaneously infected mice and guinea pigs.https://journal.microbe.ru/jour/article/view/1002plague agentlpscorevirulence |
| spellingShingle | S. V. Dentovskaya M. E. Platonov T. I. Kombarova G. M. Titareva I. V. Bakhteeva R. Z. Shaikhutdinova S. A. Ivanov A. P. Anisimov Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence Проблемы особо опасных инфекций plague agent lps core virulence |
| title | Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence |
| title_full | Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence |
| title_fullStr | Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence |
| title_full_unstemmed | Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence |
| title_short | Truncation of Lipopolysaccharide Core Decreases <i>Yersinia pestis</i> Virulence |
| title_sort | truncation of lipopolysaccharide core decreases i yersinia pestis i virulence |
| topic | plague agent lps core virulence |
| url | https://journal.microbe.ru/jour/article/view/1002 |
| work_keys_str_mv | AT svdentovskaya truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT meplatonov truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT tikombarova truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT gmtitareva truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT ivbakhteeva truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT rzshaikhutdinova truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT saivanov truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence AT apanisimov truncationoflipopolysaccharidecoredecreasesiyersiniapestisivirulence |