Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice
Backgrounds: The prevalence of mental disorders has increased in the last decades. Risperidone is a second-generation antipsychotic drug used for major depressive disorder treatment. Our study aims to investigate the effects of risperidone on the expression of adhesion molecules involved in inflamma...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915323001221 |
| _version_ | 1797802145812054016 |
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| author | Tabassum Akter Md. Monirul Islam Khadiza Begum Rahima Begum Souraov Roy Md. Abdur Rahman Ripon Mohammad Tohidul Amin Mohammad Salim Hossain |
| author_facet | Tabassum Akter Md. Monirul Islam Khadiza Begum Rahima Begum Souraov Roy Md. Abdur Rahman Ripon Mohammad Tohidul Amin Mohammad Salim Hossain |
| author_sort | Tabassum Akter |
| collection | DOAJ |
| description | Backgrounds: The prevalence of mental disorders has increased in the last decades. Risperidone is a second-generation antipsychotic drug used for major depressive disorder treatment. Our study aims to investigate the effects of risperidone on the expression of adhesion molecules involved in inflammation and other related complications in a pre-established obese mice model. Methods: Two obese treatment groups were administered 0.5 mg/kg and 1 mg/kg risperidone along with high fat. After 6 weeks of treatment, the food intake, body weights, abdominal-fat weights, liver weights, lipid profile (serum triglycerides, total cholesterol, high-density lipoprotein-cholesterol), and liver functions test (serum glutamic pyruvate transaminase, serum glutamate oxaloacetic transaminase, alkaline phosphatase) were evaluated. The relative gene expressions of PPAR-gamma, VCAM-1, P-selectin, and interleukin-6 (IL-6) were also compared. Results: The results showed a significant increase in food intake (p<0.001), body weight (p<0.01), abdominal-fat weight (p<0.01), liver weight (p<0.01), triglycerides (p<0.01), total cholesterol (p<0.05), serum glutamic pyruvate transaminase (p<0.05), serum glutamate oxaloacetic transaminase (p<0.001), alkaline phosphatase (p<0.05) and relative gene expression of PPARγ (p<0.01), VCAM-1 (p<0.05) for risperidone treated groups compared to the obese group. The relative gene expression of IL-6 for both doses was not increased as expected compared to the obese group. Limitations: The molecular pathways of the results were undiscovered. Conclusions: The study revealed that risperidone has an inducible action on fat deposition, liver dysfunction, cardiovascular diseases, and inflammation which may be effective in weight gain management intervention and the safety of risperidone treatment in obese patients. However, further molecular studies can explore the mechanisms behind these findings. |
| first_indexed | 2024-03-13T05:01:17Z |
| format | Article |
| id | doaj.art-f0c8f68b220c413b85d302d242060e1b |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-03-13T05:01:17Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-f0c8f68b220c413b85d302d242060e1b2023-06-17T05:21:30ZengElsevierJournal of Affective Disorders Reports2666-91532023-07-0113100583Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese miceTabassum Akter0Md. Monirul Islam1Khadiza Begum2Rahima Begum3Souraov Roy4Md. Abdur Rahman Ripon5Mohammad Tohidul Amin6Mohammad Salim Hossain7Department of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, Bangladesh; Department of Pharmacy, Ranada Prasad Shaha University, Shitalakhya, 1400 Narayanganj, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, BangladeshDepartment of Pharmacy, Noakhali Science and Technology University, 3814 Noakhali, Bangladesh; Corresponding author.Backgrounds: The prevalence of mental disorders has increased in the last decades. Risperidone is a second-generation antipsychotic drug used for major depressive disorder treatment. Our study aims to investigate the effects of risperidone on the expression of adhesion molecules involved in inflammation and other related complications in a pre-established obese mice model. Methods: Two obese treatment groups were administered 0.5 mg/kg and 1 mg/kg risperidone along with high fat. After 6 weeks of treatment, the food intake, body weights, abdominal-fat weights, liver weights, lipid profile (serum triglycerides, total cholesterol, high-density lipoprotein-cholesterol), and liver functions test (serum glutamic pyruvate transaminase, serum glutamate oxaloacetic transaminase, alkaline phosphatase) were evaluated. The relative gene expressions of PPAR-gamma, VCAM-1, P-selectin, and interleukin-6 (IL-6) were also compared. Results: The results showed a significant increase in food intake (p<0.001), body weight (p<0.01), abdominal-fat weight (p<0.01), liver weight (p<0.01), triglycerides (p<0.01), total cholesterol (p<0.05), serum glutamic pyruvate transaminase (p<0.05), serum glutamate oxaloacetic transaminase (p<0.001), alkaline phosphatase (p<0.05) and relative gene expression of PPARγ (p<0.01), VCAM-1 (p<0.05) for risperidone treated groups compared to the obese group. The relative gene expression of IL-6 for both doses was not increased as expected compared to the obese group. Limitations: The molecular pathways of the results were undiscovered. Conclusions: The study revealed that risperidone has an inducible action on fat deposition, liver dysfunction, cardiovascular diseases, and inflammation which may be effective in weight gain management intervention and the safety of risperidone treatment in obese patients. However, further molecular studies can explore the mechanisms behind these findings.http://www.sciencedirect.com/science/article/pii/S2666915323001221RisperidoneObesityInflammationLipid profileGene expressionMice model |
| spellingShingle | Tabassum Akter Md. Monirul Islam Khadiza Begum Rahima Begum Souraov Roy Md. Abdur Rahman Ripon Mohammad Tohidul Amin Mohammad Salim Hossain Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice Journal of Affective Disorders Reports Risperidone Obesity Inflammation Lipid profile Gene expression Mice model |
| title | Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice |
| title_full | Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice |
| title_fullStr | Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice |
| title_full_unstemmed | Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice |
| title_short | Risperidone upregulates the expression of adhesion molecules VCAM-I, and P-selectin in high-fat diet-induced obese mice |
| title_sort | risperidone upregulates the expression of adhesion molecules vcam i and p selectin in high fat diet induced obese mice |
| topic | Risperidone Obesity Inflammation Lipid profile Gene expression Mice model |
| url | http://www.sciencedirect.com/science/article/pii/S2666915323001221 |
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