Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior
Several hydrogels based on 2-hydroxyethyl methacrylate and a methacrylic monomer containing a thiazole group in its lateral chain have been prepared by thermal polymerization at 60 °C in water solution varying the chemical composition of the gels. The posterior quaternization of the thiazole groups...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/12/2853 |
| _version_ | 1797546274589769728 |
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| author | Alexandra Muñoz-Bonilla Jakub Zagora Daniela Plachá Coro Echeverría Alberto Chiloeches Marta Fernández-García |
| author_facet | Alexandra Muñoz-Bonilla Jakub Zagora Daniela Plachá Coro Echeverría Alberto Chiloeches Marta Fernández-García |
| author_sort | Alexandra Muñoz-Bonilla |
| collection | DOAJ |
| description | Several hydrogels based on 2-hydroxyethyl methacrylate and a methacrylic monomer containing a thiazole group in its lateral chain have been prepared by thermal polymerization at 60 °C in water solution varying the chemical composition of the gels. The posterior quaternization of the thiazole groups with methyl iodine has rendered positively charged hydrogels with potential antimicrobial activity. This modification has been structurally characterized by infrared spectroscopy, whereas the thermal stability of all hydrogels has been studied by thermal degradation in inert atmosphere. The swelling behavior in distilled water and the rheology of the different hydrogels have been analyzed as a function of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) monomer content as well as its methylation. Finally, the active character of hydrogels against Gram-positive and Gram-negative bacteria and fungi has been evaluated, revealing excellent antimicrobial activity against all tested microorganisms. The methylated hydrogels could be used as potential materials for wound healing or contact lens applications. |
| first_indexed | 2024-03-10T14:27:43Z |
| format | Article |
| id | doaj.art-f0cb03fd007341a98caab8dde0aa1611 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T14:27:43Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-f0cb03fd007341a98caab8dde0aa16112023-11-20T22:54:02ZengMDPI AGPolymers2073-43602020-11-011212285310.3390/polym12122853Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial BehaviorAlexandra Muñoz-Bonilla0Jakub Zagora1Daniela Plachá2Coro Echeverría3Alberto Chiloeches4Marta Fernández-García5Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainNanotechnology Centre, VŠB–Technical University of Ostrava, 15. Listopadu 2172/15, 70800 Ostrava-Poruba, Czech RepublicNanotechnology Centre, VŠB–Technical University of Ostrava, 15. Listopadu 2172/15, 70800 Ostrava-Poruba, Czech RepublicInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainInstituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), C/Juan de la Cierva 3, 28006 Madrid, SpainSeveral hydrogels based on 2-hydroxyethyl methacrylate and a methacrylic monomer containing a thiazole group in its lateral chain have been prepared by thermal polymerization at 60 °C in water solution varying the chemical composition of the gels. The posterior quaternization of the thiazole groups with methyl iodine has rendered positively charged hydrogels with potential antimicrobial activity. This modification has been structurally characterized by infrared spectroscopy, whereas the thermal stability of all hydrogels has been studied by thermal degradation in inert atmosphere. The swelling behavior in distilled water and the rheology of the different hydrogels have been analyzed as a function of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) monomer content as well as its methylation. Finally, the active character of hydrogels against Gram-positive and Gram-negative bacteria and fungi has been evaluated, revealing excellent antimicrobial activity against all tested microorganisms. The methylated hydrogels could be used as potential materials for wound healing or contact lens applications.https://www.mdpi.com/2073-4360/12/12/2853hydrogelthiazolequaternizationantimicrobial |
| spellingShingle | Alexandra Muñoz-Bonilla Jakub Zagora Daniela Plachá Coro Echeverría Alberto Chiloeches Marta Fernández-García Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior Polymers hydrogel thiazole quaternization antimicrobial |
| title | Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior |
| title_full | Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior |
| title_fullStr | Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior |
| title_full_unstemmed | Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior |
| title_short | Chemical Hydrogels Bearing Thiazolium Groups with a Broad Spectrum of Antimicrobial Behavior |
| title_sort | chemical hydrogels bearing thiazolium groups with a broad spectrum of antimicrobial behavior |
| topic | hydrogel thiazole quaternization antimicrobial |
| url | https://www.mdpi.com/2073-4360/12/12/2853 |
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