Recent Discoveries on Marine Organism Immunomodulatory Activities
Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/7/422 |
| _version_ | 1797417404884582400 |
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| author | Eleonora Montuori Donatella de Pascale Chiara Lauritano |
| author_facet | Eleonora Montuori Donatella de Pascale Chiara Lauritano |
| author_sort | Eleonora Montuori |
| collection | DOAJ |
| description | Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs. |
| first_indexed | 2024-03-09T06:18:16Z |
| format | Article |
| id | doaj.art-f0cbf1fb4ee74f2ab03a8e47c30bd2de |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T06:18:16Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-f0cbf1fb4ee74f2ab03a8e47c30bd2de2023-12-03T11:51:32ZengMDPI AGMarine Drugs1660-33972022-06-0120742210.3390/md20070422Recent Discoveries on Marine Organism Immunomodulatory ActivitiesEleonora Montuori0Donatella de Pascale1Chiara Lauritano2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d’Alcontres 31, 98166 Messina, ItalyEcosustainable Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Via Acton 55, 80133 Naples, ItalyEcosustainable Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Via Acton 55, 80133 Naples, ItalyMarine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs.https://www.mdpi.com/1660-3397/20/7/422marine organismsimmunomodulatory activityinflammationmarine drugscancer |
| spellingShingle | Eleonora Montuori Donatella de Pascale Chiara Lauritano Recent Discoveries on Marine Organism Immunomodulatory Activities Marine Drugs marine organisms immunomodulatory activity inflammation marine drugs cancer |
| title | Recent Discoveries on Marine Organism Immunomodulatory Activities |
| title_full | Recent Discoveries on Marine Organism Immunomodulatory Activities |
| title_fullStr | Recent Discoveries on Marine Organism Immunomodulatory Activities |
| title_full_unstemmed | Recent Discoveries on Marine Organism Immunomodulatory Activities |
| title_short | Recent Discoveries on Marine Organism Immunomodulatory Activities |
| title_sort | recent discoveries on marine organism immunomodulatory activities |
| topic | marine organisms immunomodulatory activity inflammation marine drugs cancer |
| url | https://www.mdpi.com/1660-3397/20/7/422 |
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