Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil
Background: Human papillomavirus (HPV) is the most common viral sexually transmitted infection of the reproductive tract, and cervical cancer is the most common HPV-related disease. This study estimated the prevalence, diversity of HPV genotypes, and associated risk factors in women screened for cer...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/9/960 |
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| author | Jacqueline Cortinhas Monteiro Mihoko Yamamoto Tsutsumi Deivid Oliveira de Carvalho Elenice do Carmo da Silva Costa Rosimar Neris Martins Feitosa Rogério Valois Laurentino Ricardo Roberto de Souza Fonseca Rodrigo Vellasco Duarte Silvestre Aldemir Branco Oliveira-Filho Luiz Fernando Almeida Machado |
| author_facet | Jacqueline Cortinhas Monteiro Mihoko Yamamoto Tsutsumi Deivid Oliveira de Carvalho Elenice do Carmo da Silva Costa Rosimar Neris Martins Feitosa Rogério Valois Laurentino Ricardo Roberto de Souza Fonseca Rodrigo Vellasco Duarte Silvestre Aldemir Branco Oliveira-Filho Luiz Fernando Almeida Machado |
| author_sort | Jacqueline Cortinhas Monteiro |
| collection | DOAJ |
| description | Background: Human papillomavirus (HPV) is the most common viral sexually transmitted infection of the reproductive tract, and cervical cancer is the most common HPV-related disease. This study estimated the prevalence, diversity of HPV genotypes, and associated risk factors in women screened for cervical cancer in northern Brazil. Methods: The cross-sectional study was conducted in Belém, Pará, in the Amazon region of Brazil, and it included 162 women who were spontaneously undergoing a Pap-smear routine. Epidemiological, sexual, and health-related information was collected by interviews, and cervical samples were collected for cytological examination and HPV-DNA detection. HPV genotypes were classified as low risk (LR) and high risk (HR) by nucleotide sequencing. Results: In total, 17.3% (28/162) of the participants had HPV-DNA, and LR-HPV was the most prevalent (71.4%). Among the 13 different types of HPV detected, HPV-11 was found most frequently (12/28; 42.9%), followed by HPV-31 (3/28; 10.7%). Of the participants with cytological alterations, HPV infection was detected in only four: two were diagnosed with low-grade squamous intraepithelial lesions (15.4%), one with atypical squamous cells of undetermined significance (7.7%), and one with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (7.7%). Of the 61 women who presented a normal cytology, 13 (21.3%) had positive tests for HPV infection, 4 (8.2%) of which were positive for a high-risk genotype. Conclusion: The prevalence of HPV was high in Belém, Pará, and especially in women who had normal cytology results, which suggests the need for greater screening for HPV infection in women’s primary health care. |
| first_indexed | 2024-03-09T22:54:44Z |
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| id | doaj.art-f0cc24c88e324e338328f60fbb4fd736 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T22:54:44Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-f0cc24c88e324e338328f60fbb4fd7362023-11-23T18:15:04ZengMDPI AGPathogens2076-08172022-08-0111996010.3390/pathogens11090960Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern BrazilJacqueline Cortinhas Monteiro0Mihoko Yamamoto Tsutsumi1Deivid Oliveira de Carvalho2Elenice do Carmo da Silva Costa3Rosimar Neris Martins Feitosa4Rogério Valois Laurentino5Ricardo Roberto de Souza Fonseca6Rodrigo Vellasco Duarte Silvestre7Aldemir Branco Oliveira-Filho8Luiz Fernando Almeida Machado9Biology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilLaboratory of Cytopathology, Institute of Biological Sciences, Federal University of Pará, Belem 66075-110, PA, BrazilBiology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilBiology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilBiology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilBiology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilBiology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilEvandro Chagas Institute, Health Ministry of Brazil, Ananindeua 67030-000, PA, BrazilStudy and Research Group on Vulnerable Populations, Institute for Coastal Studies, Federal University of Pará, Bragança 68600-000, PA, BrazilBiology of Infectious and Parasitic Agents Post-Graduate Program, Federal University of Pará, Belem 66075-110, PA, BrazilBackground: Human papillomavirus (HPV) is the most common viral sexually transmitted infection of the reproductive tract, and cervical cancer is the most common HPV-related disease. This study estimated the prevalence, diversity of HPV genotypes, and associated risk factors in women screened for cervical cancer in northern Brazil. Methods: The cross-sectional study was conducted in Belém, Pará, in the Amazon region of Brazil, and it included 162 women who were spontaneously undergoing a Pap-smear routine. Epidemiological, sexual, and health-related information was collected by interviews, and cervical samples were collected for cytological examination and HPV-DNA detection. HPV genotypes were classified as low risk (LR) and high risk (HR) by nucleotide sequencing. Results: In total, 17.3% (28/162) of the participants had HPV-DNA, and LR-HPV was the most prevalent (71.4%). Among the 13 different types of HPV detected, HPV-11 was found most frequently (12/28; 42.9%), followed by HPV-31 (3/28; 10.7%). Of the participants with cytological alterations, HPV infection was detected in only four: two were diagnosed with low-grade squamous intraepithelial lesions (15.4%), one with atypical squamous cells of undetermined significance (7.7%), and one with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesions (7.7%). Of the 61 women who presented a normal cytology, 13 (21.3%) had positive tests for HPV infection, 4 (8.2%) of which were positive for a high-risk genotype. Conclusion: The prevalence of HPV was high in Belém, Pará, and especially in women who had normal cytology results, which suggests the need for greater screening for HPV infection in women’s primary health care.https://www.mdpi.com/2076-0817/11/9/960epidemiologyvirusesviral geneticsinfectious diseasesHPV |
| spellingShingle | Jacqueline Cortinhas Monteiro Mihoko Yamamoto Tsutsumi Deivid Oliveira de Carvalho Elenice do Carmo da Silva Costa Rosimar Neris Martins Feitosa Rogério Valois Laurentino Ricardo Roberto de Souza Fonseca Rodrigo Vellasco Duarte Silvestre Aldemir Branco Oliveira-Filho Luiz Fernando Almeida Machado Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil Pathogens epidemiology viruses viral genetics infectious diseases HPV |
| title | Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil |
| title_full | Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil |
| title_fullStr | Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil |
| title_full_unstemmed | Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil |
| title_short | Prevalence, Diversity, and Risk Factors for Cervical HPV Infection in Women Screened for Cervical Cancer in Belém, Pará, Northern Brazil |
| title_sort | prevalence diversity and risk factors for cervical hpv infection in women screened for cervical cancer in belem para northern brazil |
| topic | epidemiology viruses viral genetics infectious diseases HPV |
| url | https://www.mdpi.com/2076-0817/11/9/960 |
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