Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity
Objectives: Time-to-detection (TTD) in culture on liquid media is inversely correlated to bacillary load and should be a contributing factor for assessing tuberculosis transmission. We wanted to assess if TTD was a better alternative than smear status to estimate transmission risk. Methods: From Oct...
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Format: | Article |
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Elsevier
2023-09-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223006513 |
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author | Karine Risso Céline Michelangeli Alice Gaudart Mathieu Buscot Emmanuel Chamorey Johan Courjon Michel Carles |
author_facet | Karine Risso Céline Michelangeli Alice Gaudart Mathieu Buscot Emmanuel Chamorey Johan Courjon Michel Carles |
author_sort | Karine Risso |
collection | DOAJ |
description | Objectives: Time-to-detection (TTD) in culture on liquid media is inversely correlated to bacillary load and should be a contributing factor for assessing tuberculosis transmission. We wanted to assess if TTD was a better alternative than smear status to estimate transmission risk. Methods: From October 2015 to June 2022, we retrospectively studied a cohort of index cases (IC) with pulmonary tuberculosis (tuberculosis disease [TD]) from which samples were culture-positive before treatment. We studied the correlation between TTD and contact-positivity (CP) of IC contacts: CP was defined as CP = 1 (CP group) in case of TD or latent tuberculosis infection (LTI) in at least one screened contact of an IC, and CP = 0 otherwise (contact-negativity [CN] group). Univariate and multivariable analyses (logistic regression) were done. Results: Of the 185 IC, 122 were included, generating 846 contact cases of which 705 were assessed. A transmission event (LTI or TD) was identified in 193 contact cases (transmission rate: 27%). At day 9, 66% and 35% of the IC had their sample positive in culture for CP and CN groups, respectively. Age and TTD ≤9 days were independent criteria of CP (odds ratio 0.97, confidence interval [0.95-0.98], P = 0.002 and odds ratio 3.52, confidence interval [1.59-7.83], P = 0.001, respectively). Conclusion: TTD was a more discriminating parameter than smear status to evaluate the transmission risk of an IC with pulmonary tuberculosis. Therefore, TTD should be considered in the contact-screening strategy around an IC. |
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id | doaj.art-f0cc6da24a874b0c9a4fb3090dde36c8 |
institution | Directory Open Access Journal |
issn | 1201-9712 |
language | English |
last_indexed | 2024-03-12T17:12:52Z |
publishDate | 2023-09-01 |
publisher | Elsevier |
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series | International Journal of Infectious Diseases |
spelling | doaj.art-f0cc6da24a874b0c9a4fb3090dde36c82023-08-06T04:36:47ZengElsevierInternational Journal of Infectious Diseases1201-97122023-09-01134280284Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivityKarine Risso0Céline Michelangeli1Alice Gaudart2Mathieu Buscot3Emmanuel Chamorey4Johan Courjon5Michel Carles6Centre de Lutte Anti Tuberculeuse, Hôpital Pasteur 1, CHU de Nice, France; Service de Maladies Infectieuses et Tropicales, Hôpital l'Archet 1, CHU de Nice, FranceCentre de Lutte Anti Tuberculeuse, Hôpital Pasteur 1, CHU de Nice, France; Service de Maladies Infectieuses et Tropicales, Hôpital l'Archet 1, CHU de Nice, FranceService de bactériologie, Hôpital l'Archet 2, CHU de Nice, FranceService de Maladies Infectieuses et Tropicales, Hôpital l'Archet 1, CHU de Nice, FranceDépartement d'Epidémiologie & Biostatistiques, Centre Antoine Lacassagne, Nice, France; Université Côte d'Azur, Inserm, C3M, Nice, FranceService de Maladies Infectieuses et Tropicales, Hôpital l'Archet 1, CHU de Nice, France; Université Côte d'Azur, Inserm, C3M, Nice, FranceService de Maladies Infectieuses et Tropicales, Hôpital l'Archet 1, CHU de Nice, France; Université Côte d'Azur, Inserm, C3M, Nice, France; Corresponding author: Tel.: +33 4 92 03 5 55 15; fax: +33 4 92 03 90 66.Objectives: Time-to-detection (TTD) in culture on liquid media is inversely correlated to bacillary load and should be a contributing factor for assessing tuberculosis transmission. We wanted to assess if TTD was a better alternative than smear status to estimate transmission risk. Methods: From October 2015 to June 2022, we retrospectively studied a cohort of index cases (IC) with pulmonary tuberculosis (tuberculosis disease [TD]) from which samples were culture-positive before treatment. We studied the correlation between TTD and contact-positivity (CP) of IC contacts: CP was defined as CP = 1 (CP group) in case of TD or latent tuberculosis infection (LTI) in at least one screened contact of an IC, and CP = 0 otherwise (contact-negativity [CN] group). Univariate and multivariable analyses (logistic regression) were done. Results: Of the 185 IC, 122 were included, generating 846 contact cases of which 705 were assessed. A transmission event (LTI or TD) was identified in 193 contact cases (transmission rate: 27%). At day 9, 66% and 35% of the IC had their sample positive in culture for CP and CN groups, respectively. Age and TTD ≤9 days were independent criteria of CP (odds ratio 0.97, confidence interval [0.95-0.98], P = 0.002 and odds ratio 3.52, confidence interval [1.59-7.83], P = 0.001, respectively). Conclusion: TTD was a more discriminating parameter than smear status to evaluate the transmission risk of an IC with pulmonary tuberculosis. Therefore, TTD should be considered in the contact-screening strategy around an IC.http://www.sciencedirect.com/science/article/pii/S1201971223006513TransmissionTime-to-detectionIndex casesContact screeningSmear statusMycobacterium tuberculosis |
spellingShingle | Karine Risso Céline Michelangeli Alice Gaudart Mathieu Buscot Emmanuel Chamorey Johan Courjon Michel Carles Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity International Journal of Infectious Diseases Transmission Time-to-detection Index cases Contact screening Smear status Mycobacterium tuberculosis |
title | Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity |
title_full | Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity |
title_fullStr | Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity |
title_full_unstemmed | Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity |
title_short | Time-to-detection in culture of Mycobacterium tuberculosis: performance for assessing index cases contact-positivity |
title_sort | time to detection in culture of mycobacterium tuberculosis performance for assessing index cases contact positivity |
topic | Transmission Time-to-detection Index cases Contact screening Smear status Mycobacterium tuberculosis |
url | http://www.sciencedirect.com/science/article/pii/S1201971223006513 |
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