Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome
Over the past decade, the scientific research has shown that the community of microorganisms that inhabit the gut, known as the gut microbiota, is closely linked to human health and disease, in part as a result of its influence on the systemic immune responses. The accumulated evidence suggests that...
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| Format: | Article |
| Language: | English |
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Eco-vector
2024-01-01
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| Series: | Клиническая практика |
| Subjects: | |
| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/623044/pdf |
| _version_ | 1797261540935598080 |
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| author | Мadina А. Omarova Аleksey N. Boyko |
| author_facet | Мadina А. Omarova Аleksey N. Boyko |
| author_sort | Мadina А. Omarova |
| collection | DOAJ |
| description | Over the past decade, the scientific research has shown that the community of microorganisms that inhabit the gut, known as the gut microbiota, is closely linked to human health and disease, in part as a result of its influence on the systemic immune responses. The accumulated evidence suggests that these effects on the immune system are significant in neuroinflammatory diseases such as multiple sclerosis, and that modulation of the gut microbiota may be a potential therapeutic target in these conditions. In recent years, more and more studies have been appearing devoted to the role of microbiota in the development of various pathological processes in the central nervous system, including multiple sclerosis, through the brain-gut axis. In this regard, the question of finding ways to influence the microbiome is interesting. In addition to the existing attempts through the use of probiotics and fecal microbiota transplantation, of particular interest is the search for other ways of influencing the microbiome, including the effect of multiple sclerosis modifying therapies on the microbiota’s composition. The purpose of this review is to summarize the current evidence investigating the effects of disease-modifying treatment on the gut microbiome. |
| first_indexed | 2024-04-24T23:42:51Z |
| format | Article |
| id | doaj.art-f0cd252389e54d3b828f0b4108071845 |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-04-24T23:42:51Z |
| publishDate | 2024-01-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-f0cd252389e54d3b828f0b41080718452024-03-15T11:16:13ZengEco-vectorКлиническая практика2220-30952618-86272024-01-01144889310.17816/clinpract62304478406Effects of disease-modifying drugs in multiple sclerosis on the gut microbiomeМadina А. Omarova0https://orcid.org/0000-0002-6744-2191Аleksey N. Boyko1https://orcid.org/0000-0002-2975-4151Federal Center of Brain Research and NeurotechnologiesFederal Center of Brain Research and NeurotechnologiesOver the past decade, the scientific research has shown that the community of microorganisms that inhabit the gut, known as the gut microbiota, is closely linked to human health and disease, in part as a result of its influence on the systemic immune responses. The accumulated evidence suggests that these effects on the immune system are significant in neuroinflammatory diseases such as multiple sclerosis, and that modulation of the gut microbiota may be a potential therapeutic target in these conditions. In recent years, more and more studies have been appearing devoted to the role of microbiota in the development of various pathological processes in the central nervous system, including multiple sclerosis, through the brain-gut axis. In this regard, the question of finding ways to influence the microbiome is interesting. In addition to the existing attempts through the use of probiotics and fecal microbiota transplantation, of particular interest is the search for other ways of influencing the microbiome, including the effect of multiple sclerosis modifying therapies on the microbiota’s composition. The purpose of this review is to summarize the current evidence investigating the effects of disease-modifying treatment on the gut microbiome.https://journals.eco-vector.com/clinpractice/article/viewFile/623044/pdfgut microbiomegut-brain axismultiple sclerosisdisease-modifying treatment |
| spellingShingle | Мadina А. Omarova Аleksey N. Boyko Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome Клиническая практика gut microbiome gut-brain axis multiple sclerosis disease-modifying treatment |
| title | Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome |
| title_full | Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome |
| title_fullStr | Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome |
| title_full_unstemmed | Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome |
| title_short | Effects of disease-modifying drugs in multiple sclerosis on the gut microbiome |
| title_sort | effects of disease modifying drugs in multiple sclerosis on the gut microbiome |
| topic | gut microbiome gut-brain axis multiple sclerosis disease-modifying treatment |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/623044/pdf |
| work_keys_str_mv | AT madinaaomarova effectsofdiseasemodifyingdrugsinmultiplesclerosisonthegutmicrobiome AT alekseynboyko effectsofdiseasemodifyingdrugsinmultiplesclerosisonthegutmicrobiome |