Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis

Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis

Apolipoprotein H (APOH) downregulation can cause hepatic steatosis and gut microbiota dysbiosis. However, the mechanism by which APOH-regulated lipid metabolism contributes to metabolic dysfunction–associated steatotic liver disease (MASLD) remains undetermined. Herein, we aim to explore the regulat...

Full description

Bibliographic Details
Main Authors:	Yaming Liu, Yiqun Zhao, Qiusong Liu, Binbin Li, P. Vineeth Daniel, Binbin Chen, Zeyi Wu
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	Journal of Lipid Research
Subjects:	apolipoprotein H cholesterol/metabolism bile acids and salts triglycerides de novo lipogenesis hepatocyte
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227523001566

Similar Items

Alcohol-dependent downregulation of apolipoprotein H exacerbates fatty liver and gut microbiota dysbiosis in mice
by: Yaming Liu, et al.
Published: (2022-09-01)

Streptozotocin-induced diabetes in human apolipoprotein B transgenic mice: effects on lipoproteins and atherosclerosis
by: Yuko Kako, et al.
Published: (1999-12-01)

Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer proteins⃞
by: Thomas Gautier, et al.
Published: (2007-01-01)

Genetically modified mice for the study of apolipoprotein B
by: Edward Kim, et al.
Published: (1998-04-01)

Thematic review series: Patient-Oriented Research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques
by: Elizabeth J. Parks, et al.
Published: (2006-08-01)

Metabolic-associated fatty liver disease and lipoprotein metabolism
by: Joerg Heeren, et al.
Published: (2021-08-01)

Diminished gene expression of ileal apical sodium bile acid transporter explains impaired absorption of bile acid in patients with hypertriglyceridemia
by: William C. Duane, et al.
Published: (2000-09-01)

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
by: Johanna Matilainen, et al.
Published: (2020-04-01)

Lipoprotein(a) levels, apo(a) isoform size, and coronary heart disease risk in the Framingham Offspring Study
by: Stefania Lamon-Fava, et al.
Published: (2011-06-01)

Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia
by: Jeffrey Wang, et al.
Published: (2024-07-01)

Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice
by: Aldo Grefhorst, et al.
Published: (2009-07-01)

Gender and age effects on the expression of genes related to lipid metabolism in broiler's liver
by: Angélica de Souza Khatlab, et al.
Published: (2018-03-01)

Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes
by: MARIANA CIFUENTES, et al.
Published: (2008-01-01)

Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice
by: Hiroaki Yagyu, et al.
Published: (1999-09-01)

Apolipoprotein H-based prognostic risk correlates with liver lipid metabolism disorder in patients with HBV-related hepatocellular carcinoma
by: Yaming Liu, et al.
Published: (2024-05-01)

In vivo 2H2O administration reveals impaired triglyceride storage in adipose tissue of insulin-resistant humans1
by: Candice A. Allister, et al.
Published: (2015-02-01)

Maternal Plasma Lipid Concentration in Third Trimester of Women with Preeclampsia and Normotensive Pregnancy
by: Ghada Mohammed, et al.
Published: (2020-04-01)

A diet high in glucose and deficient in dietary fibre causes fat accumulation in the liver without weight gain
by: Sonoko Karino, et al.
Published: (2024-12-01)

Liver proteomics identifies a disconnect between proteins associated with de novo lipogenesis and triglyceride storage
by: Lewin Small, et al.
Published: (2024-12-01)

Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum
by: Yuxin Wang, et al.
Published: (2011-06-01)

The apolipoprotein C-III (Gln38Lys) variant associated with human hypertriglyceridemia is a gain-of-function mutation
by: Meenakshi Sundaram, et al.
Published: (2017-11-01)

Comprehensive evaluation of apolipoprotein H gene (APOH) variation identifies novel associations with measures of lipid metabolism in GENOA*s⃞
by: Magalie S. Leduc, et al.
Published: (2008-12-01)

Lipid Metabolism Disorders as Diagnostic Biosignatures in Sepsis
by: Charlotte Birner, et al.
Published: (2024-08-01)

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor
by: Christophe Gardès, et al.
Published: (2011-06-01)

SLC16A7 Promotes Triglyceride Deposition by De Novo Lipogenesis in Chicken Muscle Tissue
by: Yongli Wang, et al.
Published: (2022-10-01)

Preliminary probiotic and technological characterization of Pediococcus pentosaceus strain KID7 and in vivo assessment of its cholesterol-lowering activity
by: Karthiyaini eDamodharan, et al.
Published: (2015-08-01)

Sortilin enhances secretion of apolipoprotein(a) through effects on apolipoprotein B secretion and promotes uptake of lipoprotein(a)
by: Justin R. Clark, et al.
Published: (2022-06-01)

Apolipoprotein C3: form begets function
by: Karin E. Bornfeldt
Published: (2024-01-01)

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis
by: Yanmei Yuan, et al.
Published: (2024-05-01)

Apolipoprotein B/A1 Ratio as a Diagnostic Alternative to Triglycerides and HDL-Cholesterol for the Prediction of Metabolic Syndrome among Hypertensives in Kazakhstan
by: Alma Nurtazina, et al.
Published: (2020-07-01)

Apolipoprotein A5-1131T>C Polymorphism Associated with Lipid Profile in Babol Population
by: SH Shojaee, et al.
Published: (2010-04-01)

Glycerol Kinase Drives Hepatic de novo Lipogenesis and Triglyceride Synthesis in Nonalcoholic Fatty Liver by Activating SREBP‐1c Transcription, Upregulating DGAT1/2 Expression, and Promoting Glycerol Metabolism
by: Shuyu Ouyang, et al.
Published: (2024-12-01)

RECHERCHES Distribution anormale des apolipoprotéines CIII et diminution de la capacité d’efflux de cholestérol du plasma de sujets normolipidémiques présentant une maladie coronarienne précoce
by: Delplanque Bernadette, et al.
Published: (2002-07-01)

Evaluación de las concentraciones de lípidos y apoproteínas A-I y B-100 en un grupo de escolares de cinco departamentos del centro-oriente de Colombia
by: Elpidia Poveda, et al.
Published: (2007-09-01)

Polimorfismo genético de la apolipoproteína E en un grupo de escolares del centro-oriente colombiano: comparación con las concentraciones plasmáticas de lípidos y apolipoproteínas
by: Ney Callas, et al.
Published: (2007-12-01)

Apolipoprotein A-IV involves in glucose and lipid metabolism of rat
by: Zhenguo Wang, et al.
Published: (2019-07-01)

Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia
by: Ken Ohashi, et al.
Published: (2000-08-01)

Elevated Levels of Apolipoprotein CIII Increase the Risk of Postprandial Hypertriglyceridemia
by: Yunpeng Guan, et al.
Published: (2021-04-01)

Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
by: Lisa C. Hudgins, et al.
Published: (2000-04-01)

Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier
by: Emmanuelle Berger, et al.
Published: (2019-01-01)