Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study
Abstract Background This study examined fatigue in patients treated for childhood acute lymphoblastic leukemia (ALL) over a 2-year period (3- to 27-months post-treatment completion), from the perspective of children and parent caregivers, compared to a healthy comparison group. Methods Eighty-three...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Health and Quality of Life Outcomes |
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| Online Access: | https://doi.org/10.1186/s12955-024-02241-2 |
| _version_ | 1797247034644758528 |
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| author | S. Walsh M. Mulraney M.C. McCarthy Cinzia R. De Luca |
| author_facet | S. Walsh M. Mulraney M.C. McCarthy Cinzia R. De Luca |
| author_sort | S. Walsh |
| collection | DOAJ |
| description | Abstract Background This study examined fatigue in patients treated for childhood acute lymphoblastic leukemia (ALL) over a 2-year period (3- to 27-months post-treatment completion), from the perspective of children and parent caregivers, compared to a healthy comparison group. Methods Eighty-three patients (4–16 years at enrolment) and their parents, reported on the child’s fatigue using the Pediatric Quality of Life Inventory– Multidimensional Fatigue Scale (PedsQL-MFS), at 3- 15- and 27-months post-treatment completion, and 53 healthy children and their parents reported on fatigue across the same timepoints. Results Parent proxy-reporting showed that parents of ALL patients reported more total fatigue than parents of the comparison group at all time points, with all subscales elevated (general, cognitive, and sleep/rest fatigue). In contrast, patient self-report of fatigue over this period differed from the comparison children for the general fatigue subscale only. Self-reported total fatigue was worse than the comparison group at the 27-month timepoint, with cognitive and sleep/rest fatigue symptoms contributing to this difference. Expected improvements in fatigue over time were not evident in either patient or parent report and no demographic risk factors were identified. Parents and children from both groups reported significantly more fatigue at all time points compared to commonly utilised normative population data. Conclusions Patients treated for childhood ALL are impacted by fatigue symptoms in the post-treatment and early survivorship period. These findings highlight that patients in the 2-years following treatment require increased symptom surveillance and may benefit particularly from interventions that target cognitive and sleep/rest fatigue. |
| first_indexed | 2024-04-24T19:52:17Z |
| format | Article |
| id | doaj.art-f0ce16b7e85d4d06ad3c721c46e02894 |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-04-24T19:52:17Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-f0ce16b7e85d4d06ad3c721c46e028942024-03-24T12:34:35ZengBMCHealth and Quality of Life Outcomes1477-75252024-03-0122111010.1186/s12955-024-02241-2Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal studyS. Walsh0M. Mulraney1M.C. McCarthy2Cinzia R. De Luca3Institute for Social Neuroscience, ISN PsychologyInstitute for Social Neuroscience, ISN PsychologyClinical Sciences, Murdoch Children’s Research InstituteClinical Sciences, Murdoch Children’s Research InstituteAbstract Background This study examined fatigue in patients treated for childhood acute lymphoblastic leukemia (ALL) over a 2-year period (3- to 27-months post-treatment completion), from the perspective of children and parent caregivers, compared to a healthy comparison group. Methods Eighty-three patients (4–16 years at enrolment) and their parents, reported on the child’s fatigue using the Pediatric Quality of Life Inventory– Multidimensional Fatigue Scale (PedsQL-MFS), at 3- 15- and 27-months post-treatment completion, and 53 healthy children and their parents reported on fatigue across the same timepoints. Results Parent proxy-reporting showed that parents of ALL patients reported more total fatigue than parents of the comparison group at all time points, with all subscales elevated (general, cognitive, and sleep/rest fatigue). In contrast, patient self-report of fatigue over this period differed from the comparison children for the general fatigue subscale only. Self-reported total fatigue was worse than the comparison group at the 27-month timepoint, with cognitive and sleep/rest fatigue symptoms contributing to this difference. Expected improvements in fatigue over time were not evident in either patient or parent report and no demographic risk factors were identified. Parents and children from both groups reported significantly more fatigue at all time points compared to commonly utilised normative population data. Conclusions Patients treated for childhood ALL are impacted by fatigue symptoms in the post-treatment and early survivorship period. These findings highlight that patients in the 2-years following treatment require increased symptom surveillance and may benefit particularly from interventions that target cognitive and sleep/rest fatigue.https://doi.org/10.1186/s12955-024-02241-2ALLLeukemiaFatigueChemotherapyPediatricOncology |
| spellingShingle | S. Walsh M. Mulraney M.C. McCarthy Cinzia R. De Luca Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study Health and Quality of Life Outcomes ALL Leukemia Fatigue Chemotherapy Pediatric Oncology |
| title | Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study |
| title_full | Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study |
| title_fullStr | Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study |
| title_full_unstemmed | Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study |
| title_short | Fatigue in children who have recently completed treatment for acute lymphoblastic leukemia: a longitudinal study |
| title_sort | fatigue in children who have recently completed treatment for acute lymphoblastic leukemia a longitudinal study |
| topic | ALL Leukemia Fatigue Chemotherapy Pediatric Oncology |
| url | https://doi.org/10.1186/s12955-024-02241-2 |
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