Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice
Obesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mice, suggesting that agents able to stimulate this...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29231-6 |
| _version_ | 1811311698312691712 |
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| author | Takefumi Kimura Sai P. Pydi Lei Wang Dhanush Haspula Yinghong Cui Huiyan Lu Gabriele M. König Evi Kostenis Gregory R. Steinberg Oksana Gavrilova Jürgen Wess |
| author_facet | Takefumi Kimura Sai P. Pydi Lei Wang Dhanush Haspula Yinghong Cui Huiyan Lu Gabriele M. König Evi Kostenis Gregory R. Steinberg Oksana Gavrilova Jürgen Wess |
| author_sort | Takefumi Kimura |
| collection | DOAJ |
| description | Obesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mice, suggesting that agents able to stimulate this pathway may prove useful as antidiabetic drugs. |
| first_indexed | 2024-04-13T10:22:24Z |
| format | Article |
| id | doaj.art-f0d1158d61ee4a5a901478e2a9b74e39 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T10:22:24Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f0d1158d61ee4a5a901478e2a9b74e392022-12-22T02:50:27ZengNature PortfolioNature Communications2041-17232022-03-0113111710.1038/s41467-022-29231-6Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in miceTakefumi Kimura0Sai P. Pydi1Lei Wang2Dhanush Haspula3Yinghong Cui4Huiyan Lu5Gabriele M. König6Evi Kostenis7Gregory R. Steinberg8Oksana Gavrilova9Jürgen Wess10Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesMouse Transgenic Core Facility, National Institute of Diabetes and Digestive and Kidney DiseasesInstitute of Pharmaceutical Biology, University of BonnMolecular, Cellular and Pharmacobiology Section, Institute of Pharmaceutical Biology, University of BonnCenter for Metabolism, Obesity and Diabetes Research, Department of Medicine and Department of Biochemistry and Biomedical Sciences, McMaster UniversityMouse Metabolism Core National Institute of Diabetes and Digestive and Kidney DiseasesMolecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney DiseasesObesity impairs regulation of adipocyte lipolysis, which contributes towards development of insulin resistance. Here the authors report that adipocyte Gq signaling functions as a regulator of lipolysis and systemic glucose and lipid homeostasis in mice, suggesting that agents able to stimulate this pathway may prove useful as antidiabetic drugs.https://doi.org/10.1038/s41467-022-29231-6 |
| spellingShingle | Takefumi Kimura Sai P. Pydi Lei Wang Dhanush Haspula Yinghong Cui Huiyan Lu Gabriele M. König Evi Kostenis Gregory R. Steinberg Oksana Gavrilova Jürgen Wess Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice Nature Communications |
| title | Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice |
| title_full | Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice |
| title_fullStr | Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice |
| title_full_unstemmed | Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice |
| title_short | Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice |
| title_sort | adipocyte gq signaling is a regulator of glucose and lipid homeostasis in mice |
| url | https://doi.org/10.1038/s41467-022-29231-6 |
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