Recent Advances in the Aging Microenvironment of Breast Cancer
Aging is one of the risk factors for advanced breast cancer. With the increasing trend toward population aging, it is important to study the effects of aging on breast cancer in depth. Cellular senescence and changes in the aging microenvironment in vivo are the basis for body aging and death. In th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/20/4990 |
| _version_ | 1797474610936020992 |
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| author | Xiaocong Jiang Haixing Shen Xi Shang Jianwen Fang Yuexin Lu Yue Lu Jingyan Zheng Peifen Fu |
| author_facet | Xiaocong Jiang Haixing Shen Xi Shang Jianwen Fang Yuexin Lu Yue Lu Jingyan Zheng Peifen Fu |
| author_sort | Xiaocong Jiang |
| collection | DOAJ |
| description | Aging is one of the risk factors for advanced breast cancer. With the increasing trend toward population aging, it is important to study the effects of aging on breast cancer in depth. Cellular senescence and changes in the aging microenvironment in vivo are the basis for body aging and death. In this review, we focus on the influence of the aging microenvironment on breast cancer. Increased breast extracellular matrix stiffness in the aging breast extracellular matrix can promote the invasion of breast cancer cells. The role of senescence-associated secretory phenotypes (SASPs) such as interleukin-6 (IL-6), IL-8, and matrix metalloproteases (MMPs), in breast cancer cell proliferation, invasion, and metastasis is worthy of exploration. Furthermore, the impact of senescent fibroblasts, adipocytes, and endothelial cells on the mammary matrix is discussed in detail. We also list potential targets for senotherapeutics and senescence-inducing agents in the aging microenvironment of breast cancer. In conclusion, this review offers an overview of the influence of the aging microenvironment on breast cancer initiation and progression, with the aim of providing some directions for future research on the aging microenvironment in breast cancer. |
| first_indexed | 2024-03-09T20:32:36Z |
| format | Article |
| id | doaj.art-f0d35ae2bea8490bb1b85547bbcc0e9c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T20:32:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f0d35ae2bea8490bb1b85547bbcc0e9c2023-11-23T23:20:06ZengMDPI AGCancers2072-66942022-10-011420499010.3390/cancers14204990Recent Advances in the Aging Microenvironment of Breast CancerXiaocong Jiang0Haixing Shen1Xi Shang2Jianwen Fang3Yuexin Lu4Yue Lu5Jingyan Zheng6Peifen Fu7Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaSchool of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Breast and Thyroid Surgery, Taizhou Hospital, Zhejiang University, Taizhou 318000, ChinaDepartment of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Breast and Thyroid Surgery, First Affiliated Hospital of Huzhou University, Huzhou 313000, ChinaDepartment of Breast and Thyroid Surgery, Lishui People’s Hospital, The Six Affiliated Hospital of Wenzhou Medical University, Lishui 323000, ChinaDepartment of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaAging is one of the risk factors for advanced breast cancer. With the increasing trend toward population aging, it is important to study the effects of aging on breast cancer in depth. Cellular senescence and changes in the aging microenvironment in vivo are the basis for body aging and death. In this review, we focus on the influence of the aging microenvironment on breast cancer. Increased breast extracellular matrix stiffness in the aging breast extracellular matrix can promote the invasion of breast cancer cells. The role of senescence-associated secretory phenotypes (SASPs) such as interleukin-6 (IL-6), IL-8, and matrix metalloproteases (MMPs), in breast cancer cell proliferation, invasion, and metastasis is worthy of exploration. Furthermore, the impact of senescent fibroblasts, adipocytes, and endothelial cells on the mammary matrix is discussed in detail. We also list potential targets for senotherapeutics and senescence-inducing agents in the aging microenvironment of breast cancer. In conclusion, this review offers an overview of the influence of the aging microenvironment on breast cancer initiation and progression, with the aim of providing some directions for future research on the aging microenvironment in breast cancer.https://www.mdpi.com/2072-6694/14/20/4990breast canceragingtumor microenvironment |
| spellingShingle | Xiaocong Jiang Haixing Shen Xi Shang Jianwen Fang Yuexin Lu Yue Lu Jingyan Zheng Peifen Fu Recent Advances in the Aging Microenvironment of Breast Cancer Cancers breast cancer aging tumor microenvironment |
| title | Recent Advances in the Aging Microenvironment of Breast Cancer |
| title_full | Recent Advances in the Aging Microenvironment of Breast Cancer |
| title_fullStr | Recent Advances in the Aging Microenvironment of Breast Cancer |
| title_full_unstemmed | Recent Advances in the Aging Microenvironment of Breast Cancer |
| title_short | Recent Advances in the Aging Microenvironment of Breast Cancer |
| title_sort | recent advances in the aging microenvironment of breast cancer |
| topic | breast cancer aging tumor microenvironment |
| url | https://www.mdpi.com/2072-6694/14/20/4990 |
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