Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis
Background Helicobacter pylori (H. pylori) infection affects ≈4.4 billion people worldwide. Several studies suggest that this pathogen impacts the digestive system, causing diverse and severe conditions, and results in extragastrointestinal disorders like vascular diseases. Our study aims to examine...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-02-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.022919 |
| _version_ | 1797631007255429120 |
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| author | Orsolya Anna Simon Anikó Görbe Péter Hegyi Lajos Szakó Eduard Oštarijaš Fanni Dembrovszky Szabolcs Kiss László Czopf Bálint Erőss Imre Szabó |
| author_facet | Orsolya Anna Simon Anikó Görbe Péter Hegyi Lajos Szakó Eduard Oštarijaš Fanni Dembrovszky Szabolcs Kiss László Czopf Bálint Erőss Imre Szabó |
| author_sort | Orsolya Anna Simon |
| collection | DOAJ |
| description | Background Helicobacter pylori (H. pylori) infection affects ≈4.4 billion people worldwide. Several studies suggest that this pathogen impacts the digestive system, causing diverse and severe conditions, and results in extragastrointestinal disorders like vascular diseases. Our study aims to examine the association between H. pylori infection and carotid intima‐media thickness. Methods and Results Electronic databases (MEDLINE, Embase, CENTRAL, Web of Science, and Scopus) were searched for studies, comparing the thickness of the carotid intima‐media in H. pylori–infected and noninfected individuals listed until October 20, 2020. Statistical analyses were performed using the random effects meta‐analysis of model of weighted mean differences with the corresponding 95% CI using the DerSimonian and Laird method. The protocol was registered in advance in PROSPERO (International Prospective Register of Systematic Reviews; CRD42021224485). Thirteen studies were found meeting inclusion criteria for our systematic review and meta‐analysis, presenting data on the thickness of the carotid intima‐media considering the presence of H. pylori infection. Altogether, 2298 individuals’ data were included (1360 H. pylori positive, 938 negative). The overall carotid intima‐media thickness was significantly larger among infected patients compared with uninfected participants (weighted mean difference: 0.07 mm; 95% CI, 0.02–0.12; P=0.004; I2=91.1%; P<0.001). In case of the right common carotid artery, the intima‐media thickening was found to be significant as well (weighted mean difference, 0.08 mm; 95% CI, 0.02–0.13, P=0.007; I2=85.1%; P<0.001), while it showed no significance in the left common carotid artery (weighted mean difference, 0.12 mm; 95% CI, −0.05 to 0.28, P=0.176; I2=97.4%; P<0.001). Conclusions H. pylori infection is associated with increased carotid intima‐media thickness. Therefore, the infection may indirectly contribute to the development of major vascular events. |
| first_indexed | 2024-03-11T11:16:01Z |
| format | Article |
| id | doaj.art-f0d38d6147c14552b44cc97b9470dee2 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-11T11:16:01Z |
| publishDate | 2022-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-f0d38d6147c14552b44cc97b9470dee22023-11-11T04:49:37ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-02-0111310.1161/JAHA.121.022919Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐AnalysisOrsolya Anna Simon0Anikó Görbe1Péter Hegyi2Lajos Szakó3Eduard Oštarijaš4Fanni Dembrovszky5Szabolcs Kiss6László Czopf7Bálint Erőss8Imre Szabó9Institute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryDivision of Cardiology First Department of Medicine Medical School University of Pécs HungaryInstitute for Translational Medicine, Medical SchoolUniversity of Pécs HungaryDivision of Gastroenterology First Department of Medicine Medical School University of Pécs HungaryBackground Helicobacter pylori (H. pylori) infection affects ≈4.4 billion people worldwide. Several studies suggest that this pathogen impacts the digestive system, causing diverse and severe conditions, and results in extragastrointestinal disorders like vascular diseases. Our study aims to examine the association between H. pylori infection and carotid intima‐media thickness. Methods and Results Electronic databases (MEDLINE, Embase, CENTRAL, Web of Science, and Scopus) were searched for studies, comparing the thickness of the carotid intima‐media in H. pylori–infected and noninfected individuals listed until October 20, 2020. Statistical analyses were performed using the random effects meta‐analysis of model of weighted mean differences with the corresponding 95% CI using the DerSimonian and Laird method. The protocol was registered in advance in PROSPERO (International Prospective Register of Systematic Reviews; CRD42021224485). Thirteen studies were found meeting inclusion criteria for our systematic review and meta‐analysis, presenting data on the thickness of the carotid intima‐media considering the presence of H. pylori infection. Altogether, 2298 individuals’ data were included (1360 H. pylori positive, 938 negative). The overall carotid intima‐media thickness was significantly larger among infected patients compared with uninfected participants (weighted mean difference: 0.07 mm; 95% CI, 0.02–0.12; P=0.004; I2=91.1%; P<0.001). In case of the right common carotid artery, the intima‐media thickening was found to be significant as well (weighted mean difference, 0.08 mm; 95% CI, 0.02–0.13, P=0.007; I2=85.1%; P<0.001), while it showed no significance in the left common carotid artery (weighted mean difference, 0.12 mm; 95% CI, −0.05 to 0.28, P=0.176; I2=97.4%; P<0.001). Conclusions H. pylori infection is associated with increased carotid intima‐media thickness. Therefore, the infection may indirectly contribute to the development of major vascular events.https://www.ahajournals.org/doi/10.1161/JAHA.121.022919atherosclerosiscarotid intima‐media thicknessHelicobacter pyloriinfectionmeta‐analysis |
| spellingShingle | Orsolya Anna Simon Anikó Görbe Péter Hegyi Lajos Szakó Eduard Oštarijaš Fanni Dembrovszky Szabolcs Kiss László Czopf Bálint Erőss Imre Szabó Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerosis carotid intima‐media thickness Helicobacter pylori infection meta‐analysis |
| title | Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis |
| title_full | Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis |
| title_fullStr | Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis |
| title_short | Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta‐Analysis |
| title_sort | helicobacter pylori infection is associated with carotid intima and media thickening a systematic review and meta analysis |
| topic | atherosclerosis carotid intima‐media thickness Helicobacter pylori infection meta‐analysis |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.022919 |
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