Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study
Objectives To investigate the association between breast feeding and infant development during the first year of life using sibling comparison.Design Nationwide prospective birth cohort study with sibling pair analysis.Setting 15 regional centres that participated in the Japan Environment and Childr...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/8/e043202.full |
| _version_ | 1826945175626186752 |
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| author | Koichi Kusuhara Yasunari Sakai Yuko Ichimiya Michiko Torio Masafumi Sanefuji Shouichi Ohga Satoshi Honjo Ayako Senju Masayuki Shimono Masanobu Ogawa Yuri Sonoda Reiko Suga |
| author_facet | Koichi Kusuhara Yasunari Sakai Yuko Ichimiya Michiko Torio Masafumi Sanefuji Shouichi Ohga Satoshi Honjo Ayako Senju Masayuki Shimono Masanobu Ogawa Yuri Sonoda Reiko Suga |
| author_sort | Koichi Kusuhara |
| collection | DOAJ |
| description | Objectives To investigate the association between breast feeding and infant development during the first year of life using sibling comparison.Design Nationwide prospective birth cohort study with sibling pair analysis.Setting 15 regional centres that participated in the Japan Environment and Children’s Study.Participants This study included 77 119 children (singleton, term birth and no malformation/severe diseases) whose mothers were registered between January 2011 and March 2014, including 3521 duos or trios of siblings.Primary outcome measures The primary outcome was developmental delay at 6 and 12 months of age, assessed using the Japanese translation of the Ages and Stages Questionnaires, third edition. Multivariable regression analyses adjusted for confounders were performed to estimate the risk ratios of delay associated with any or exclusive breast feeding. Pairs of siblings discordant for statuses were selected, and conditional regression analyses were conducted with a matched cohort design.Results Developmental delay was identified in 6162 (8.4%) and 10 442 (14.6%) children at 6 and 12 months of age, respectively. Any breast feeding continued until 6 months or 12 months old was associated with reduced developmental delay at 12 months of age (adjusted risk ratio (95% CI): 0.81 (0.77 to 0.85) and 0.81 (0.78 to 0.84), respectively). Furthermore, exclusive breast feeding until 3 months was associated with reduced developmental delay at 12 months of age (adjusted risk ratio, 0.86 (95% CI 0.83 to 0.90)). In sibling pair analysis, the association between any breast feeding until 12 months and reduced developmental delay at 12 months of age persisted (adjusted risk ratio, 0.64 (95% CI 0.43 to 0.93)).Conclusions The present study demonstrated the association of continuous breast feeding with reduced developmental delay at 1 year of age using sibling pair analysis, in which unmeasured confounding factors are still present but less included. This may provide an argument to promote breastfeeding continuation. |
| first_indexed | 2024-12-16T09:05:27Z |
| format | Article |
| id | doaj.art-f0d5faf1f69942d1ab745904e04ded91 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-02-17T20:50:41Z |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj.art-f0d5faf1f69942d1ab745904e04ded912024-12-09T07:30:11ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-043202Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s StudyKoichi Kusuhara0Yasunari Sakai1Yuko Ichimiya2Michiko Torio3Masafumi Sanefuji4Shouichi Ohga5Satoshi Honjo6Ayako Senju7Masayuki Shimono8Masanobu Ogawa9Yuri Sonoda10Reiko Suga11Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Pediatrics, Kyushu University, Fukuoka, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanPediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Pediatrics, National Hospital Organization Fukuoka National Hospital, Fukuoka, JapanDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, JapanResearch Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, JapanResearch Center for Environment and Developmental Medical Sciences, Kyushu University, Fukuoka, JapanRegional Center for Japan Environment and Children`s Study, University of Occupational and Environmental Health, Kitakyushu, JapanObjectives To investigate the association between breast feeding and infant development during the first year of life using sibling comparison.Design Nationwide prospective birth cohort study with sibling pair analysis.Setting 15 regional centres that participated in the Japan Environment and Children’s Study.Participants This study included 77 119 children (singleton, term birth and no malformation/severe diseases) whose mothers were registered between January 2011 and March 2014, including 3521 duos or trios of siblings.Primary outcome measures The primary outcome was developmental delay at 6 and 12 months of age, assessed using the Japanese translation of the Ages and Stages Questionnaires, third edition. Multivariable regression analyses adjusted for confounders were performed to estimate the risk ratios of delay associated with any or exclusive breast feeding. Pairs of siblings discordant for statuses were selected, and conditional regression analyses were conducted with a matched cohort design.Results Developmental delay was identified in 6162 (8.4%) and 10 442 (14.6%) children at 6 and 12 months of age, respectively. Any breast feeding continued until 6 months or 12 months old was associated with reduced developmental delay at 12 months of age (adjusted risk ratio (95% CI): 0.81 (0.77 to 0.85) and 0.81 (0.78 to 0.84), respectively). Furthermore, exclusive breast feeding until 3 months was associated with reduced developmental delay at 12 months of age (adjusted risk ratio, 0.86 (95% CI 0.83 to 0.90)). In sibling pair analysis, the association between any breast feeding until 12 months and reduced developmental delay at 12 months of age persisted (adjusted risk ratio, 0.64 (95% CI 0.43 to 0.93)).Conclusions The present study demonstrated the association of continuous breast feeding with reduced developmental delay at 1 year of age using sibling pair analysis, in which unmeasured confounding factors are still present but less included. This may provide an argument to promote breastfeeding continuation.https://bmjopen.bmj.com/content/11/8/e043202.full |
| spellingShingle | Koichi Kusuhara Yasunari Sakai Yuko Ichimiya Michiko Torio Masafumi Sanefuji Shouichi Ohga Satoshi Honjo Ayako Senju Masayuki Shimono Masanobu Ogawa Yuri Sonoda Reiko Suga Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study BMJ Open |
| title | Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study |
| title_full | Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study |
| title_fullStr | Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study |
| title_full_unstemmed | Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study |
| title_short | Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study |
| title_sort | breast feeding and infant development in a cohort with sibling pair analysis the japan environment and children s study |
| url | https://bmjopen.bmj.com/content/11/8/e043202.full |
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