IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study
Abstract Background Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalence of asymptomatic cardiovascular ventricular dysfunction. Inflammation...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-021-02138-8 |
| _version_ | 1819145619630981120 |
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| author | Jennifer M. T. A. Meessen Giulia Cesaroni Gian F. Mureddu Alessandro Boccanelli Ursula-Henrike Wienhues-Thelen Peter Kastner Luisa Ojeda-Fernandez Deborah Novelli Gianfranco Bazzoni Maurizio Mangiavacchi Nera Agabiti Serge Masson Lidia Staszewsky Roberto Latini on behalf of the PREDICTOR Investigators |
| author_facet | Jennifer M. T. A. Meessen Giulia Cesaroni Gian F. Mureddu Alessandro Boccanelli Ursula-Henrike Wienhues-Thelen Peter Kastner Luisa Ojeda-Fernandez Deborah Novelli Gianfranco Bazzoni Maurizio Mangiavacchi Nera Agabiti Serge Masson Lidia Staszewsky Roberto Latini on behalf of the PREDICTOR Investigators |
| author_sort | Jennifer M. T. A. Meessen |
| collection | DOAJ |
| description | Abstract Background Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalence of asymptomatic cardiovascular ventricular dysfunction. Inflammation and fibrosis are hallmarks of cardiac aging and remodelling. Therefore, we assessed the clinical performance of IGFBP7 and two other biomarkers reflecting these pathogenic pathways, the growth differentiation factor-15 (GFD-15) and amino-terminal propeptide of type I procollagen (P1NP), for their association with cardiac phenotypes and outcomes in the PREDICTOR study. Methods 2001 community-dwelling subjects aged 65–84 years who had undergone centrally-read echocardiography, were selected through administrative registries. Atrial fibrillation (AF) and 4 echocardiographic patterns were assessed: E/e’ (> 8), enlarged left atrial area, left ventricular hypertrophy (LVH) and reduced midwall circumference shortening (MFS). All-cause and cardiovascular mortality and hospitalization were recorded over a median follow-up of 10.6 years. Results IGFBP7 and GDF-15, but not P1NP, were independently associated with prevalent AF and echocardiographic variables after adjusting for age and sex. After adjustment for clinical risk factors and cardiac patterns or NT-proBNP and hsTnT, both IGFBP7 and GDF-15 independently predicted all-cause mortality, hazard ratios 2.13[1.08–4.22] and 2.03[1.62–2.56] per unit increase of Ln-transformed markers, respectively. Conclusions In a community-based elderly cohort, IGFBP7 and GDF-15 appear associated to cardiac alterations as well as to 10-year risk of all-cause mortality. |
| first_indexed | 2024-12-22T13:00:55Z |
| format | Article |
| id | doaj.art-f0d616715a21480bbf7f4cf7c81ae1b4 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-22T13:00:55Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f0d616715a21480bbf7f4cf7c81ae1b42022-12-21T18:25:00ZengBMCBMC Cardiovascular Disorders1471-22612021-07-0121111310.1186/s12872-021-02138-8IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based studyJennifer M. T. A. Meessen0Giulia Cesaroni1Gian F. Mureddu2Alessandro Boccanelli3Ursula-Henrike Wienhues-Thelen4Peter Kastner5Luisa Ojeda-Fernandez6Deborah Novelli7Gianfranco Bazzoni8Maurizio Mangiavacchi9Nera Agabiti10Serge Masson11Lidia Staszewsky12Roberto Latini13on behalf of the PREDICTOR InvestigatorsDepartment of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Epidemiology, Lazio Regional Health ServiceDepartment of Cardiovascular Diseases, S Giovanni-Addolorata HospitalCasa di Cura QuisisanaRoche Diagnostics GmbHRoche Diagnostics GmbHDepartment of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCSCentro Medico Specialistico UniSalusDepartment of Epidemiology, Lazio Regional Health ServiceRoche Diagnostics InternationalDepartment of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCSDepartment of Cardiovascular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCSAbstract Background Little is known about the clinical value of Insulin-like growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, in an elderly general population with multiple co-morbidities and high prevalence of asymptomatic cardiovascular ventricular dysfunction. Inflammation and fibrosis are hallmarks of cardiac aging and remodelling. Therefore, we assessed the clinical performance of IGFBP7 and two other biomarkers reflecting these pathogenic pathways, the growth differentiation factor-15 (GFD-15) and amino-terminal propeptide of type I procollagen (P1NP), for their association with cardiac phenotypes and outcomes in the PREDICTOR study. Methods 2001 community-dwelling subjects aged 65–84 years who had undergone centrally-read echocardiography, were selected through administrative registries. Atrial fibrillation (AF) and 4 echocardiographic patterns were assessed: E/e’ (> 8), enlarged left atrial area, left ventricular hypertrophy (LVH) and reduced midwall circumference shortening (MFS). All-cause and cardiovascular mortality and hospitalization were recorded over a median follow-up of 10.6 years. Results IGFBP7 and GDF-15, but not P1NP, were independently associated with prevalent AF and echocardiographic variables after adjusting for age and sex. After adjustment for clinical risk factors and cardiac patterns or NT-proBNP and hsTnT, both IGFBP7 and GDF-15 independently predicted all-cause mortality, hazard ratios 2.13[1.08–4.22] and 2.03[1.62–2.56] per unit increase of Ln-transformed markers, respectively. Conclusions In a community-based elderly cohort, IGFBP7 and GDF-15 appear associated to cardiac alterations as well as to 10-year risk of all-cause mortality.https://doi.org/10.1186/s12872-021-02138-8IGFBP7GDF-15P1NPCardiac remodellingCommunity-dwelling elderly |
| spellingShingle | Jennifer M. T. A. Meessen Giulia Cesaroni Gian F. Mureddu Alessandro Boccanelli Ursula-Henrike Wienhues-Thelen Peter Kastner Luisa Ojeda-Fernandez Deborah Novelli Gianfranco Bazzoni Maurizio Mangiavacchi Nera Agabiti Serge Masson Lidia Staszewsky Roberto Latini on behalf of the PREDICTOR Investigators IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study BMC Cardiovascular Disorders IGFBP7 GDF-15 P1NP Cardiac remodelling Community-dwelling elderly |
| title | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
| title_full | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
| title_fullStr | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
| title_full_unstemmed | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
| title_short | IGFBP7 and GDF-15, but not P1NP, are associated with cardiac alterations and 10-year outcome in an elderly community-based study |
| title_sort | igfbp7 and gdf 15 but not p1np are associated with cardiac alterations and 10 year outcome in an elderly community based study |
| topic | IGFBP7 GDF-15 P1NP Cardiac remodelling Community-dwelling elderly |
| url | https://doi.org/10.1186/s12872-021-02138-8 |
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