How HIV Takes Advantage of the Cytoskeleton in Entry and Replication
The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-03-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/3/4/293/ |
| _version_ | 1823993054875353088 |
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| author | Oliver T. Fackler Bettina Stolp |
| author_facet | Oliver T. Fackler Bettina Stolp |
| author_sort | Oliver T. Fackler |
| collection | DOAJ |
| description | The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells. |
| first_indexed | 2024-12-18T16:15:50Z |
| format | Article |
| id | doaj.art-f0da017439e84d5391957d53fca8db31 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-18T16:15:50Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f0da017439e84d5391957d53fca8db312022-12-21T21:01:55ZengMDPI AGViruses1999-49152011-03-013429331110.3390/v3040293How HIV Takes Advantage of the Cytoskeleton in Entry and ReplicationOliver T. FacklerBettina StolpThe host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.http://www.mdpi.com/1999-4915/3/4/293/HIVactin cytoskeletonentryNefcofilin |
| spellingShingle | Oliver T. Fackler Bettina Stolp How HIV Takes Advantage of the Cytoskeleton in Entry and Replication Viruses HIV actin cytoskeleton entry Nef cofilin |
| title | How HIV Takes Advantage of the Cytoskeleton in Entry and Replication |
| title_full | How HIV Takes Advantage of the Cytoskeleton in Entry and Replication |
| title_fullStr | How HIV Takes Advantage of the Cytoskeleton in Entry and Replication |
| title_full_unstemmed | How HIV Takes Advantage of the Cytoskeleton in Entry and Replication |
| title_short | How HIV Takes Advantage of the Cytoskeleton in Entry and Replication |
| title_sort | how hiv takes advantage of the cytoskeleton in entry and replication |
| topic | HIV actin cytoskeleton entry Nef cofilin |
| url | http://www.mdpi.com/1999-4915/3/4/293/ |
| work_keys_str_mv | AT olivertfackler howhivtakesadvantageofthecytoskeletoninentryandreplication AT bettinastolp howhivtakesadvantageofthecytoskeletoninentryandreplication |