Innate Immune Function of Mitochondrial Metabolism
Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance th...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00527/full |
| _version_ | 1818502085366251520 |
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| author | David Sancho Michel Enamorado Johan Garaude |
| author_facet | David Sancho Michel Enamorado Johan Garaude |
| author_sort | David Sancho |
| collection | DOAJ |
| description | Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing immune cell function. Mitochondria are at the core of metabolic adaptation to the changing environment. The close interaction between mitochondrial metabolism and immune signaling has emerged as a central regulator of innate sensing. Metabolic processes generate a constant flow of electrons that eventually end up in the mitochondrial electron transport chain (ETC). Two electron carriers and four respiratory complexes that can assemble as larger molecular supercomplexes compose the ETC in the mitochondrial inner membrane. While the meaning and biological relevance of such structural organization is a matter of passionate debates, recent data support that innate stimuli remodel the ETC. We will review the function of mitochondrial metabolism and ETC dynamics as innate rheostats that regulate signaling, transcription, and epigenetics to orchestrate innate immune responses. |
| first_indexed | 2024-12-10T21:05:04Z |
| format | Article |
| id | doaj.art-f0dc0566a89b4d118fbc890f939ec1ae |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T21:05:04Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f0dc0566a89b4d118fbc890f939ec1ae2022-12-22T01:33:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-05-01810.3389/fimmu.2017.00527250424Innate Immune Function of Mitochondrial MetabolismDavid Sancho0Michel Enamorado1Johan Garaude2Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, SpainInstitute for Regenerative Medicine and Biotherapy, INSERM U1183, Montpellier, FranceSensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing immune cell function. Mitochondria are at the core of metabolic adaptation to the changing environment. The close interaction between mitochondrial metabolism and immune signaling has emerged as a central regulator of innate sensing. Metabolic processes generate a constant flow of electrons that eventually end up in the mitochondrial electron transport chain (ETC). Two electron carriers and four respiratory complexes that can assemble as larger molecular supercomplexes compose the ETC in the mitochondrial inner membrane. While the meaning and biological relevance of such structural organization is a matter of passionate debates, recent data support that innate stimuli remodel the ETC. We will review the function of mitochondrial metabolism and ETC dynamics as innate rheostats that regulate signaling, transcription, and epigenetics to orchestrate innate immune responses.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00527/fullinnate immune responseimmunometabolismelectron transport chainmitochondriamacrophagesdendritic cells |
| spellingShingle | David Sancho Michel Enamorado Johan Garaude Innate Immune Function of Mitochondrial Metabolism Frontiers in Immunology innate immune response immunometabolism electron transport chain mitochondria macrophages dendritic cells |
| title | Innate Immune Function of Mitochondrial Metabolism |
| title_full | Innate Immune Function of Mitochondrial Metabolism |
| title_fullStr | Innate Immune Function of Mitochondrial Metabolism |
| title_full_unstemmed | Innate Immune Function of Mitochondrial Metabolism |
| title_short | Innate Immune Function of Mitochondrial Metabolism |
| title_sort | innate immune function of mitochondrial metabolism |
| topic | innate immune response immunometabolism electron transport chain mitochondria macrophages dendritic cells |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00527/full |
| work_keys_str_mv | AT davidsancho innateimmunefunctionofmitochondrialmetabolism AT michelenamorado innateimmunefunctionofmitochondrialmetabolism AT johangaraude innateimmunefunctionofmitochondrialmetabolism |