Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep
Four half-sib families (n = 382) consisting predominantly of ITT × Merino × Merino backcross progeny, including some F2 progeny were used to analyze QTL for two production traits (Birth weight = BW1 and Body weight at 360 days = BW360). The study exploited differences in weight performance between t...
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Format: | Article |
Language: | English |
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Bogor Agricultural University
2006-03-01
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Series: | Hayati Journal of Biosciences |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S197830191630376X |
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author | ENDANG TRI MARGAWATI HERMAN WILLEM RAADSMA HARIMURTI MARTOJO SUBANDRIYO MULADNO |
author_facet | ENDANG TRI MARGAWATI HERMAN WILLEM RAADSMA HARIMURTI MARTOJO SUBANDRIYO MULADNO |
author_sort | ENDANG TRI MARGAWATI |
collection | DOAJ |
description | Four half-sib families (n = 382) consisting predominantly of ITT × Merino × Merino backcross progeny, including some F2 progeny were used to analyze QTL for two production traits (Birth weight = BW1 and Body weight at 360 days = BW360). The study exploited differences in weight performance between the Merino and ITT sheep. A total of 141 informative microsatellite markers were used in a genome-wide scan covering the 26 autosomal sheep chromosomes. QTL analysis was conducted online using QTL Express. This study reports the effect of QTL for birth weight on Chromosomes 5 (p ≤ 0.05) at 112cM (0cM-128cM). Location of candidate genes for birth weight was predicted at the region of flanking markers MCM527-BMS1247. A QTL for BW360 days existed on Chromosome 18 (p ≤ 0.01) at 104cM (25.0-125cM). Location of candidate genes related to production traits for body weight 360 days was predicted at the segment of flanking markers of CSSM018-TMR1. Only the QTL on Chromosome 18 retained significance (p ≤ 0.01) under experiment-wide significance testing. This QTL region is being examined for candidate genes by investigating to the homologous human chromosomal segments. |
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id | doaj.art-f0dd287aceac4eec967b53ef83e0d7ec |
institution | Directory Open Access Journal |
issn | 1978-3019 |
language | English |
last_indexed | 2024-04-12T12:35:46Z |
publishDate | 2006-03-01 |
publisher | Bogor Agricultural University |
record_format | Article |
series | Hayati Journal of Biosciences |
spelling | doaj.art-f0dd287aceac4eec967b53ef83e0d7ec2022-12-22T03:32:54ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192006-03-01131313510.1016/S1978-3019(16)30376-XQuantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross SheepENDANG TRI MARGAWATI0HERMAN WILLEM RAADSMA1HARIMURTI MARTOJO2SUBANDRIYO3MULADNO4Research Centre for Biotechnology, the Indonesian Institute of Sciences, Jalan Raya Bogor Km. 46, Cibinong 16911Faculty of Veterinary Science of the University of Sydney, AustraliaDepartment of Animal Production, Bogor Agricultural Institute, Darmaga Campus, Bogor 16680Research Institute for Animal Production, Jalan Raya Pajajaran, P.O. Box. 308, Bogor 16003Department of Animal Production, Bogor Agricultural Institute, Darmaga Campus, Bogor 16680Four half-sib families (n = 382) consisting predominantly of ITT × Merino × Merino backcross progeny, including some F2 progeny were used to analyze QTL for two production traits (Birth weight = BW1 and Body weight at 360 days = BW360). The study exploited differences in weight performance between the Merino and ITT sheep. A total of 141 informative microsatellite markers were used in a genome-wide scan covering the 26 autosomal sheep chromosomes. QTL analysis was conducted online using QTL Express. This study reports the effect of QTL for birth weight on Chromosomes 5 (p ≤ 0.05) at 112cM (0cM-128cM). Location of candidate genes for birth weight was predicted at the region of flanking markers MCM527-BMS1247. A QTL for BW360 days existed on Chromosome 18 (p ≤ 0.01) at 104cM (25.0-125cM). Location of candidate genes related to production traits for body weight 360 days was predicted at the segment of flanking markers of CSSM018-TMR1. Only the QTL on Chromosome 18 retained significance (p ≤ 0.01) under experiment-wide significance testing. This QTL region is being examined for candidate genes by investigating to the homologous human chromosomal segments.http://www.sciencedirect.com/science/article/pii/S197830191630376XQuantitative trait lociproduction traitsbirth weightweigh 360backcross sheep |
spellingShingle | ENDANG TRI MARGAWATI HERMAN WILLEM RAADSMA HARIMURTI MARTOJO SUBANDRIYO MULADNO Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep Hayati Journal of Biosciences Quantitative trait loci production traits birth weight weigh 360 backcross sheep |
title | Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep |
title_full | Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep |
title_fullStr | Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep |
title_full_unstemmed | Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep |
title_short | Quantitative Trait Loci (QTL) Analysis for Production Traits of Birth Weight and Weight 360 days in Backcross Sheep |
title_sort | quantitative trait loci qtl analysis for production traits of birth weight and weight 360 days in backcross sheep |
topic | Quantitative trait loci production traits birth weight weigh 360 backcross sheep |
url | http://www.sciencedirect.com/science/article/pii/S197830191630376X |
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