Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream
Kaposi sarcoma (KS) is a rare disease that was not frequently identified before the widespread occurrence of AIDS. Even today, it remains a challenge for physicians to diagnose, particularly in its early stages, often requiring referral to specialists and further investigations. Dermoscopy, a non-in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/18/2901 |
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| author | Carmen Cantisani Alexandru-Vasile Baja Luca Gargano Giovanni Rossi Marco Ardigò Giuseppe Soda Mehdi Boostani Norbert Kiss Giovanni Pellacani |
| author_facet | Carmen Cantisani Alexandru-Vasile Baja Luca Gargano Giovanni Rossi Marco Ardigò Giuseppe Soda Mehdi Boostani Norbert Kiss Giovanni Pellacani |
| author_sort | Carmen Cantisani |
| collection | DOAJ |
| description | Kaposi sarcoma (KS) is a rare disease that was not frequently identified before the widespread occurrence of AIDS. Even today, it remains a challenge for physicians to diagnose, particularly in its early stages, often requiring referral to specialists and further investigations. Dermoscopy, a non-invasive imaging technique, reveals a distinctive rainbow pattern that strongly indicates KS. Moreover, advanced imaging tools like optical coherence tomography (OCT) can provide additional information though specific disease-related patterns have not been fully established yet. These emerging techniques show promise in facilitating early diagnosis of skin-related KS and monitoring the effectiveness of treatments. However, biopsy remains the definitive method for confirming the disease. In this study, we present two cases of cutaneous Kaposi sarcoma, documented using OCT, both before and after treatment with imiquimod 5% cream. The study highlights the potential of OCT in evaluating disease progression and treatment response, as well as the usefulness of dermoscopy in detecting early indicators of KS. By integrating these advanced imaging techniques, the diagnosis and management of cutaneous KS could be improved, leading to timely interventions and better patient outcomes. |
| first_indexed | 2024-03-10T22:53:45Z |
| format | Article |
| id | doaj.art-f0dd433dda0d44b4928878116119d0eb |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T22:53:45Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f0dd433dda0d44b4928878116119d0eb2023-11-19T10:13:11ZengMDPI AGDiagnostics2075-44182023-09-011318290110.3390/diagnostics13182901Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% CreamCarmen Cantisani0Alexandru-Vasile Baja1Luca Gargano2Giovanni Rossi3Marco Ardigò4Giuseppe Soda5Mehdi Boostani6Norbert Kiss7Giovanni Pellacani8Dermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyPorphyria and Rare Diseases Unit, San Gallicano Dermatological Institute—IRCCS, 00144 Rome, ItalyDermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, HungaryDermatology Unit, Department of Clinical Internal Anesthesiological and Cardiovascular Sciences, “Sapienza” University of Rome, 00161 Rome, ItalyKaposi sarcoma (KS) is a rare disease that was not frequently identified before the widespread occurrence of AIDS. Even today, it remains a challenge for physicians to diagnose, particularly in its early stages, often requiring referral to specialists and further investigations. Dermoscopy, a non-invasive imaging technique, reveals a distinctive rainbow pattern that strongly indicates KS. Moreover, advanced imaging tools like optical coherence tomography (OCT) can provide additional information though specific disease-related patterns have not been fully established yet. These emerging techniques show promise in facilitating early diagnosis of skin-related KS and monitoring the effectiveness of treatments. However, biopsy remains the definitive method for confirming the disease. In this study, we present two cases of cutaneous Kaposi sarcoma, documented using OCT, both before and after treatment with imiquimod 5% cream. The study highlights the potential of OCT in evaluating disease progression and treatment response, as well as the usefulness of dermoscopy in detecting early indicators of KS. By integrating these advanced imaging techniques, the diagnosis and management of cutaneous KS could be improved, leading to timely interventions and better patient outcomes.https://www.mdpi.com/2075-4418/13/18/2901kaposi sarcomaoptical coherence tomographyimiquimodtopical treatmentdermoscopyimaging |
| spellingShingle | Carmen Cantisani Alexandru-Vasile Baja Luca Gargano Giovanni Rossi Marco Ardigò Giuseppe Soda Mehdi Boostani Norbert Kiss Giovanni Pellacani Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream Diagnostics kaposi sarcoma optical coherence tomography imiquimod topical treatment dermoscopy imaging |
| title | Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream |
| title_full | Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream |
| title_fullStr | Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream |
| title_full_unstemmed | Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream |
| title_short | Optical Coherence Tomography as a Valuable Tool for the Evaluation of Cutaneous Kaposi Sarcoma Treated with Imiquimod 5% Cream |
| title_sort | optical coherence tomography as a valuable tool for the evaluation of cutaneous kaposi sarcoma treated with imiquimod 5 cream |
| topic | kaposi sarcoma optical coherence tomography imiquimod topical treatment dermoscopy imaging |
| url | https://www.mdpi.com/2075-4418/13/18/2901 |
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